PDE4D7 Antibody

General Information

Product

PDE4D7 Antibody

Description

Affinity Purified cAMP-specific phosphodiesterase PDE4D7 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PDE4D7 variant.

Accession #

GenBank: AF536978.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.2 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q01063

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Molecular Function

Hydrolase, 3',5'-cyclic-nucleotide phosphodiesterase activity, ATPase binding

Subcellular Location

Cytoplasm. Membrane. Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Apical cell membrane

Expression

Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis.

Structure

Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Binds ARRB2. Interacts with PDE4DIP (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.

Alternative Nomenclature

DPDE3 antibody

HSPDE4D antibody

PDE43 antibody

PDE4D antibody

Phosphodiesterase 4D antibody

Phosphodiesterase 4D cAMP-specific antibody