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General Information
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Product
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Progesterone Receptor Antibody
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Description
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Affinity Purified Progesterone Receptor Antibody C-epitope
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Cat, Human, Monkey, Pig
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Immunogen
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Synthetic peptide taken within amino acid region 350-400 on human Progesterone receptor protein.
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Accession #
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GenBank: AAD01587.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.50 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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P06401
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Overview
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The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
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Molecular Function
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DNA binding; Enzyme binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; Steriod hormone receptor activity; Transcription regulation
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Subcellular Location
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Nucleus. Cytoplasm
Note: Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G1 and G2/M phases.
Isoform A : Nucleus. Cytoplasm
Note: Mainly nuclear.
Isoform 4 : Mitochondrion outer membrane
mitochondrial outer membrane
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus
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Structure
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Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.
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Alternative Nomenclature
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NR3C3 antibody
Nuclear receptor subfamily 3 group C member 3 antibody
PGR antibody
PR antibody
PR antibody
PRA antibody
PRB antibody
Progesterone receptor antibody
Progestin receptor form A antibody
Progestin receptor form B antibody
Progestin receptor form C antibody
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Progesterone Receptor Antibody FITC
Progesterone Receptor Antibody BIOTIN
Progesterone Receptor Blocking Peptide
Progesterone Receptor Positive Control
