|
General Information
|
|
|
Product
|
TLR5 Antibody
|
|
Description
|
Affinity Purified Toll-like receptor 5 Antibody
|
|
Verified Applications
|
ELISA, IP, WB
|
|
Host
|
Rabbit
|
|
Species Cross Reactivity
|
Human
|
|
Immunogen
|
Synthetic peptide taken within amino acid region 195-225 on human TLR5 protein.
|
|
Physical Properties
|
|
|
Quantity
|
100 µg
|
|
Volume
|
200 µl
|
|
Concentration
|
0.75 µg/µl in antibody stabilization buffer
|
|
Form
|
Affinity Purified
|
|
Clonality
|
Polyclonal
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
DB
|
1:20,000
|
|
ELISA
|
1:20,000
|
| Immunoprecipitation |
1:200 |
|
Western Blot
|
1:500
|
|
Protein
|
|
Uniprot #
|
O60602
|
|
Overview
|
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
|
|
Molecular Function
|
Receptor, interleukin-1 receptor binding, transmembrane signalling receptor activity
|
|
Subcellular Location
|
Membrane; Single-pass type I membrane protein
|
|
Expression
|
Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
|
|
Structure
|
Binds MYD88 via their respective TIR domains. Homodimer both in the absence and presence of ligand.
|
|
Alternative Nomenclature
|
SLEB1 antibody
TIL3 antibody
Toll like receptor 5 antibody
Toll/interleukin 1 receptor like protein 3 antibody
|
| |
|
TLR5 Antibody FITC
TLR5 Antibody BIOTIN
TLR5 Blocking Peptide
TLR5 Positive Control
