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General Information
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Product
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TLR5 Peptide
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Description
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Antigenic Blocking Peptide Toll-like receptor 5
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide taken within amino acid region 195-225 on human TLR5 protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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O60602
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Overview
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Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
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Molecular Function
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Receptor, interleukin-1 receptor binding, transmembrane signalling receptor activity
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Subcellular Location
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Membrane; Single-pass type I membrane protein
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Expression
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Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
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Structure
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Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand.
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Alternative Nomenclature
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SLEB1 antibody
TIL3 antibody
Toll like receptor 5 antibody
Toll/interleukin 1 receptor like protein 3 antibody
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TLR5 Antibody
TLR5 Antibody FITC
TLR5 Antibody BIOTIN
TLR5 Positive Control
