General Information
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Product
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TYRO3 Antibody FITC
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Description
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FITC-Conjugated Tyrosine-protein kinase receptor TYRO3 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey
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Immunogen
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Synthetic peptide taken within amino acid reigon 800-850 on human Tyrosine-protein kinase receptor TYRO3 protein.
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Accession #
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NCBI: NP_006284.2
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.65 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation |
1:200 |
Western Blot
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1:500-1:750
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Protein
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Uniprot #
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Q06418
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Overview
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Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation.
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Molecular Function
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Kinase, Receptor, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Cell membrane; Single-pass Type I membrane protein
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Expression
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Abundant in the brain and lower levels in other tissues.
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Structure
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Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity.
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Alternative Nomenclature
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Brt
BYK
DTK
RSE
SKY
Tif
TYRO3
Tyrosine-protein kinase byk
Tyrosine-protein kinase DTK
Tyrosine-protein kinase receptor TYRO3
Tyrosine-protein kinase RSE
Tyrosine-protein kinase SKY
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