TYRO3 Antibody

General Information

Product

TYRO3 Antibody

Description

Affinity Purified Tyrosine-protein kinase receptor TYRO3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid reigon 800-850 on human Tyrosine-protein kinase receptor TYRO3 protein.

Accession #

NCBI:  NP_006284.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q06418

Overview

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane; Single-pass Type I membrane protein

Expression

Abundant in the brain and lower levels in other tissues.

Structure

Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity.

Alternative Nomenclature

Brt 

BYK 

DTK 

RSE 

SKY 

Tif 

TYRO3 

Tyrosine-protein kinase byk 

Tyrosine-protein kinase DTK 

Tyrosine-protein kinase receptor TYRO3 

Tyrosine-protein kinase RSE 

Tyrosine-protein kinase SKY