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General Information
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Product
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WWOX 1/4 Antibody Affinity Purified
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Description
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Affinity Purified WW domain-containing Oxidoreductase isoform 1 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse
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Immunogen
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Synthetic peptide corresponding to unique amino acid sequence on WWOX 1 and WWOX4 protein.
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Accession #
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NCBI: NP_057457.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.62 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000-1:100,000
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ELISA
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1:10,000-1:100,000
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9NZC7
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Overview
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Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
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Molecular Function
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Coenzyme binding; protein dimerization activity; cofactor binding;
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Subcellular Location
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Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus
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Expression
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Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
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Structure
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Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.
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Alternative Nomenclature
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D16S432E antibody
FOR antibody
FOR II protein antibody
FRA16D antibody
fragile 16D oxido reductase antibody
fragile site FRA16D oxidoreductase antibody
HHCMA56 antibody
PRO0128 antibody
putative oxidoreductase antibody
WW domain-containing oxidoreductase antibody
WW domain-containing protein WWOX antibody
WWOX antibody
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WWOX 1 + 4 Antibody FITC
WWOX 1 + 4 Antibody BIOTIN
WWOX 1 + 4 Blocking Peptide
WWOX 1 + 4 Positive Control
