WWOX 1 + 4 Antibody

General Information

Product

WWOX 1/4 Antibody Affinity Purified

Description

Affinity Purified WW domain-containing Oxidoreductase isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on WWOX 1 and WWOX4 protein.

Accession #

NCBI:  NP_057457.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Western Blot

1:500

Protein

Uniprot #

Q9NZC7

Overview

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Molecular Function

Coenzyme binding; protein dimerization activity; cofactor binding;

Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus

Expression

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Structure

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.

Alternative Nomenclature

D16S432E antibody

FOR antibody

FOR II protein antibody

FRA16D antibody

fragile 16D oxido reductase antibody

fragile site FRA16D oxidoreductase antibody

HHCMA56 antibody

PRO0128 antibody

putative oxidoreductase antibody

WW domain-containing oxidoreductase antibody

WW domain-containing protein WWOX antibody

WWOX antibody