General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody Extreme C-epitope

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 700-750 on human Neprilysin protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.78 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody

General Information

Product

CD163 Antibody

Description

Affinity Purified CD163 Antibody N-epitope

Verified Applications

ELISA, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 600-650  on human CD163 protein.

Accession #

GenBank: EAW88662.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunohistochemistry

1:150

Western Blot

1:500

Protein

Uniprot #

D3DUU0

Overview

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Molecular Function

Scavenger receptor activity

Subcellular Location

Membrane

Expression

Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Structure

Interacts with CSNK2B.

Alternative Nomenclature

CD163 antigen antibody

CD163 molecule antibody

Hemoglobin Scavenger Receptor antibody

Macrophage associated antigen antibody

MM130 antibody

Scavenger receptor cysteine rich type 1 protein M130 antibody

sCD163 antibody

Soluble CD163 antibody

General Information

Product

CD163 Antibody C-epitope

Verified Applications

ELISA, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region  887-905 on human CD163 protein.

Accession #

GenBank: EAW88662.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

D3DUU0

Overview

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Molecular Function

Scavenger receptor activity

Subcellular Location

Membrane

Expression

Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Structure

Interacts with CSNK2B.

Alternative Nomenclature

CD163 antigen antibody

CD163 molecule antibody

Hemoglobin Scavenger Receptor antibody

Macrophage associated antigen antibody

MM130 antibody

Scavenger receptor cysteine rich type 1 protein M130 antibody

sCD163 antibody

Soluble CD163 antibody

General Information

Product

CD19 Antibody

Description

Affinity Purified B-lymphocyte antigen CD19 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human CD19 protein.

Accession #

NCBI: AAB60697

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P15391

Overview

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor dependent stimulation

Molecular Function

Receptor Signaling protein activity

Subcellular Location

Membrane; Single-pass type I membrane protein.

Structure

Contains 2 Ig-like C2-type domains.

Alternative Nomenclature

Antibody deficiency due to defect in CD19, included antibody

AW495831 antibody

CVID3 antibody

Leu 12 antibody

Lymphocyte Surface Antigen antibody

T-cell surface antigen Leu-12 antibody

General Information

Product

CD2 Antibody

Description

Affinity Purified T-cell surface antigen CD2 Antibody C-epitope

Verified Applications

ELISA, IP, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Predicted: Mouse, Rat

Immunogen

Accession #

NCBI:  NP_001758

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P06729

Overview

Interacts with lymphocyte function associated antigen and CD48/BCM1 to mediate adhesion between T-cells and other cells.

Molecular Function

Cell adhesion

Subcellular Location

Membrane; Single-pass type I membrane protein.

Structure

Cytoplasmic domain is implicated in signaling function.  Contains 1 Ig-like C2-type domain and 1 Ig-like V-type domain

Alternative Nomenclature

CD 2 antibody

CD2 antigen (p50), sheep red blood cell receptor antibody

CD2 antigen antibody

CD2 molecule antibody

Erythrocyte receptor antibody

FLJ46032 antibody

LFA2 antibody

LFA3 receptor antibody

Ly-37 antibody

Lymphocyte function antigen 2 antibody

OTTHUMP00000024366 antibody

p50 antibody

Rosette receptor antibody

Sheep erythrocyte receptor antibody

Sheep red blood cell receptor antibody

SRBC antibody

T cell surface antigen CD2 antibody

T cell surface antigen T11/Leu 5 antibody

T11 antibody

General Information

Product

CD2 Antibody

Description

Affinity Purified T-cell surface antigen CD2 precursor Antibody Extreme C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Predicted: Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acid region 3335-351 on human T-cell surface antigen CD2 protein.

Accession #

NCBI:  NP_001758

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P06729

Overview

Interacts with lymphocyte function associated antigen and CD48/BCM1 to mediate adhesion between T-cells and other cells.

Molecular Function

Cell adhesion

Subcellular Location

Membrane; Single-pass type I membrane protein.

Structure

Cytoplasmic domain is implicated in signaling function.  Contains 1 Ig-like C2-type domain and 1 Ig-like V-type domain

Alternative Nomenclature

CD 2 antibody

CD2 antigen (p50), sheep red blood cell receptor antibody

Erythrocyte receptor antibody

FLJ46032 antibody

LFA-2 antibody

LFA-3 receptor antibody

Ly-37 antibody

Lymphocyte function antigen 2 antibody

p50 antibody

Rosette receptor antibody

Sheep erythrocyte receptor antibody

T cell surface antigen CD2 antibody

T cell surface antigen T11/Leu 5 antibody

General Information

Product

CD21 Antibody

Description

Affinity Purified Complement Receptor Type 2 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Predicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 650-700  on human Complement Receptor type 2 isoform X1 protein.

Accession #

NCBI:  XP_011507508.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P20023

Overview

Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.

Molecular Function

Complement binding; DNA binding; Protein homodimerization activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.

Structure

Interacts (via Sushi domain 1 and 2) with C3dg.

Alternative Nomenclature

C3DR antibody

CD21 antibody

CD21 antigen antibody

Complement C3d receptor antibody

Complement component (3d/Epstein Barr virus) receptor 2 antibody

Complement component receptor 2 antibody

Cr 2 antibody

CR antibody

CVID7 antibody

EBV receptor antibody

EBV-R antibody

Epstein Barr virus receptor antibody

EVBR antibody

SLEB9 antibody

General Information

Product

CD21 Antibody

Description

Affinity Purified Complement Receptor Type 2 Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Predicted: Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 915-965  on human Complement Receptor type 2 protein.

Accession #

NCBI:  XP_011507508.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P20023

Overview

Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.

Molecular Function

Complement binding; DNA binding; Protein homodimerization activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.

Structure

Interacts (via Sushi domain 1 and 2) with C3dg.

Alternative Nomenclature

C3DR antibody

CD21 antibody

CD21 antigen antibody

Complement C3d receptor antibody

Complement component (3d/Epstein Barr virus) receptor 2 antibody

Complement component receptor 2 antibody

Cr 2 antibody

CR antibody

CVID7 antibody

EBV receptor antibody

EBV-R antibody

Epstein Barr virus receptor antibody

EVBR antibody

SLEB9 antibody

General Information

Product

CD3 epsilon Antibody

Description

Affinity Purified T-cell surface glycoprotein CD3 epsilon chain precursor Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

N-epitope synthetic peptide corresponding to unique amino acid sequence on Human CD3 epsilon protein.

Accession #

NCBI:  NP_000724.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

P07766

Overview

Mediates signal transduction

Molecular Function

Receptor; GPCR signaling pathway

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Heterodimer coexprassed at the cell surface with invariant subunits of CD3 labeled gamma, delta epsilon, zeta, eta.

Alternative Nomenclature

CD3 TCR complex antibody

IMD18 antibody

T cell antigen receptor complex epsilon subunit of T3 antibody

T-cell surface antigen T3/Leu-4 epsilon chain antibody

T3E antibody

TCRE antibody

TiT3 complex antibody

General Information

Product

CD3 epsilon Antibody

Description

Affinity Purified T-cell surface glycoprotein CD3 epsilon chain Antibody Mid-region

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Acomys cahirinus, Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on human CD3 epsilon protein.

Accession #

NCBI:  NP_000724.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

P07766

Overview

Mediates signal transduction

Molecular Function

Receptor; GPCR signaling pathway

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Heterodimer coexprassed at the cell surface with invariant subunits of CD3 labeled gamma, delta epsilon, zeta, eta.

Alternative Nomenclature

CD3 TCR complex antibody

IMD18 antibody

T cell antigen receptor complex epsilon subunit of T3 antibody

T-cell surface antigen T3/Leu-4 epsilon chain antibody

T3E antibody

TCRE antibody

TiT3 complex antibody