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ABL2 Antibody

Product no.: ABL2-201AP

$285.00

Description

General Information
Product	ABL2 Antibody
Description	Affinity Purified Tyrosine-protein kinase ABL2 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to amino acids within region 1100-1150 on human Tyrosine-protein kinase ABL2 / ARG.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5-1.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20?C for long term storage
Application Protocol
ELISA	1:50,000
Immunoprecipitation	1:200
Western Blot	1:500-1:5,000
Protein
Uniprot #	P42684
Overview	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35.
Molecular Function	actin filament binding actin monomer binding ATP binding magnesium ion binding manganese ion binding non-membrane spanning protein tyrosine kinase activity phosphotyrosine residue binding protein kinase activity protein tyrosine kinase activity
Subcellular Location	Cytoskeleton
Expression	Widely expressed.
Alternative Nomenclature	Abelson murine leukemia viral oncogene homolog 2 antibody Abelson related gene protein antibody Abelson tyrosine-protein kinase 2 antibody Abelson-related gene protein antibody ABL2 antibody ABL2_HUMAN antibody ABLL antibody ARG antibody Tyrosine kinase ARG antibody Tyrosine protein kinase ABL2 antibody Tyrosine-protein kinase ARG antibody v abl Abelson murine leukemia viral oncogene homolog 2 antibody

Protein information supplied by UniProt.