General Information

Product

ADCY6 Antibody

Description

Affinity Purified Adenylate cyclase type 6 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH.

Sequence:

DERKTAWGERNGQKR

Accession #

GenBank: AAD29856.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100-1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100-1:200

Immunofluorescence

1:100-1:200

Immunohistochemistry

1:100-1:200

Western Blot

1:500

Protein

Uniprot #

Q03343

Overview

Membrane bound calcium-inhibitable adenylyl cyclase.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane protein; Cell projection; cilium

Structure

Part of a complex containing AKAP5, ADCY5, PDE4C, PKD2. Interacts with RAF1.

Alternative Nomenclature

AC6 

ACVI 

ADCYB 

Adenylate cyclase 6 

ATP pyrophosphate-lyase 6 

Ca(2+) inhibitable adenylyl cyclase 

EC 4.6.1.1 

KIAA0422 

General Information

Product

ADCY7 Antibody

Description

Affinity Purified Particulate Adenylate cyclase type 7 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on mouse Particulate Adenylyl Cyclase 7 protein.

Accession #

NCBI:  NP_031432.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100-1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100-1:200

Immunofluorescence

1:100-1:200

Immunohistochemistry

1:100-1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P51829

Overview

Membrane bound calcium-inhibitable adenylyl cyclase.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane

Expression

Heart, spleen and lung

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.  Contains 2 guanylate cyclase domains.

Alternative Nomenclature

adenylate cyclase 7 antibody

adenylyl cyclase antibody

ATP pyrophosphate-lyase antibody

KIAA0037 antibody

General Information

Product

ADCY8 Antibody

Description

Affinity Purified Particulate adenylate cyclase 8 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human Particulate Adenylyl Cyclase 8 protein.

Accession #

GenBank:  AAZ13596.1

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q4F7X0

Overview

Involved in intracellular signal transduction and adenylate cyclase activity.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Integral component of membrane

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Alternative Nomenclature

ADCY3 antibody

ATP pyrophosphate-lyase 8 antibody

Brain adenylate cyclase 8 antibody

Ca(2+)/calmodulin activated adenylyl cyclase antibody

HBAC1 antibody

General Information

Product

ADCY9 Antibody Affinity Purified

Description

Affinity Purified Adenylate cyclase type 9 Antibody

Verified Applications

ELISA, WB; predicted to work with:  CM, ICC, IHC, IF

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60503

Overview

Plays role in interplay between intracellular calcium and cAMP.  Docking site for calcineurin.

Molecular Function

Adenylate cyclase activity; metal ion binding; ATP binding

Subcellular Location

Axon; dendrite; integral component of plasma membrane

Expression

Expressed in lung cells, airway smooth muscle

Structure

Adenylyl cyclase class-4/guanylyl cyclase family.  Contains 2 guanylate cyclase domains.

Alternative Nomenclature

ATP pyrophosphate lyase 9 antibody

KIAA0520 antibody

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

General Information

Product

ANT2 Antibody

Description

Affinity Purified ADP/ATP Translocase 2 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on human ADP/ATP translocase 2.

Sequence:

AER EFR GLG DCL VKI YKS DGI KGL YQG FNV SVQ GII IYR AAY FGI YDT AK

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500. Molecular Weight: 33-36 kDa.

Protein

Uniprot #

P05141

Overview

Catalyzes exchange of cytoplasmic ADP with mitochondrial ATP across mitochondrial inner membrane.  May also play role in chromosome segregation.

Molecular Function

Chromosome partition; Host-virus interaction; Transport

Subcellular Location

Mitochondrion inner membrane; multipass membrane protein

Structure

Homodimer, Component of MMXD complex.

Alternative Nomenclature

2F1 antibody

AAC2 antibody

Adenine nucleotide translocator 2 antibody

ADP antibody

ADP ATP carrier protein 2 antibody

ANT2 antibody

ATP carrier protein 2 antibody

fibroblast isoform antibody

SLC25A5 antibody

Solute carrier family 25 member 5 antibody

T2 antibody

T3 antibody

General Information

Product

Adenylate Cyclase 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rabbit, Rat

Immunogen

Synthetic peptide corresponding to conserved sequence at or near C terminal end of protein that is unique to rat/mouse Adenylyl Cyclase 1 protein.

Accession #

GenBank: AAC29478 

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55- 0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500. Detects a band 127-10 kDa

Protein

Uniprot #

O88444

Overview

This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina

Molecular Function

ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane protein. Cytoplasm

Expression

Expressed throughout inner ear development. Brain, retina and adrenal medulla.

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains

Alternative Nomenclature

3'5' cyclic AMP synthetase antibody

ADCY1 antibody

adenyl cyclase antibody

Adenylate cyclase 1 antibody

ATP pyrophosphate lyase antibody

Brain adenylate cyclase 1 antibody

Ca(2+)/calmodulin activated adenylyl cyclase antibody

EC 4.6.1.1 antibody

General Information

Product

Soluble Adenylate Cyclase 10 Antibody

Description

Affinity Purified Bicarbonate activated soluble adenylate cyclase 10 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Gorilla, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse Adenylate Cyclase type 10 protein.

Accession #

NCBI:  NP_766617.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q8C0T9

Overview

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.

Molecular Function

Adenylate cyclase activity; ATP binding; Magnesium ion binding; Manganese ion binding

Subcellular Location

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Expression

Expressed in testis.

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Alternative Nomenclature

3',5'-cyclic AMP synthetase antibody

Adenylate cyclase 10 (soluble) antibody

AH related protein antibody

ATP pyrophosphate-lyase antibody

Germ cell soluble adenylyl cyclase antibody

HCA2 antibody

hsAC antibody

hypercalciuria absorptive antibody

SAC antibody

SACI antibody

Sacy antibody

Soluble adenylyl cyclase antibody

Testicular soluble adenylyl cyclase antibody

General Information

Product

Adiponectin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Pig

Immunogen

Synthetic peptide taken within amino acid region 150-243 on pig Adiponectin protein.

Accession #

GenBank: AY589691

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.65 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q69907

Overview

Involved in brown fat cell differentiation, responses to drugs, detection of oxidative stress glucose homeostasis and fatty acid oxidation.  Invovled in regulation of DNA biosynthetic processes.

Molecular Function

Hormone activity; receptor binding

Subcellular Location

Cell periphery; collagen trimer; extracellular space; cell surface; endoplasmic reticulum; perinuclear region of cytoplasm

Expression

Secreted

Alternative Nomenclature

30 kDa adipocyte complement related protein antibody

ACDC antibody

ACRP 30 antibody

Adipocyte antibody

Adipocyte C1q and collagen domain containing protein antibody

Adipocyte complement related 30 kDa protein antibody

adipocyte-specific secretory protein antibody

Adiponectin antibody

adiponectin, C1Q and collagen domain containing antibody

AdipoQ antibody

Adipose most abundant gene transcript 1 antibody

Adipose specific collagen like factor antibody

ADIPQTL1 antibody

ADPN antibody

APM 1 antibody

C1q and collagen domain-containing protein antibody

GBP 28 antibody

Gelatin binding protein antibody

Gelatin binding protein 28 antibody

General Information

Product

AGE Antibody

Description

Affinity Purified Advance Glycated Endproduct Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Overview

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Molecular Function

Inflammatory Response

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Secreted

Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein

Expression

Endothelial cells.

Structure

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

Alternative Nomenclature

Advanced glycation end products antibody

AGEs antibody

General Information

Product

AIM2 Antibody

Description

Affinity Purified Interferon-inducible protein AIM2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.

Accession #

NCBI:  NP_004824

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O14862

Overview

Innate immune response recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages.  Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Molecular Function

Apoptosis, Immunity, Inflammatory response, Innate Immunity

Expression

Expressed in spleen, small intestine, peripheral blood leukocytes and testis. 

Structure

Self-associates; forms homodimers in response to cytosolic dsDNA and the dsDNA serves as oligomerization platform.

Alternative Nomenclature

Absent in melanoma 2 antibody

PYHIN4 antibody