KIRREL Antibody

Product no.: NEPH1-101AP

$320.00

Description
Publications

General Information
Product	KIRREL Antibody
Description	Affinity Purified Kin of IRRE-like protein 1 Antibody N-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 200-250 on mouse Neph1 protein.
Specificity	Extracellular domain.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.45-0.65 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:250
Western Blot	1:250
Protein
Uniprot #	Q80W68
Overview	Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Molecular Function	Myosin Binding
Subcellular Location	Cell membrane; Single-pass type I membrane protein
Expression	Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Structure	Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains).
Alternative Nomenclature	FLJ10845 antibody Kin of IRRE like (Drosophila) antibody Kin of IRRE like antibody Kin of irregular chiasm-like protein 1 antibody Kirrel antibody MGC129542 antibody MGC129543 antibody NEPH 1 antibody Nephrin like protein 1 antibody Nephrin related antibody

Protein information supplied by UniProt