General Information |
|
Product |
Bcl6 Peptide |
Description |
Antigenic Blocking Peptide B-Cell lymphoma 6 protein Mid-region |
Verified Applications |
Immunodepletion, Immunocompetition |
|
|
Immunogen |
Synthetic peptide taken within amino acid region 200-250 on human B-cell lymphoma protein isoform 1. |
Accession # |
NCBI: NP_001124317 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
Mid-region |
Storage |
-20⁰C for long term storage |
|
|
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. |
Molecular Function |
Chromatin Binding; Actin Cytoskeleton organization; Cellular response to DNA damage stimulus; Negative regulation of cell growth; Activator; Repressor |
Subcellular Location |
Nucleus |
Expression |
Expressed in germinal center T- and B-cells and in primary immature dendritic cells. |
Structure |
Homodimer. |
Alternative Nomenclature |
B cell CLL/lymphoma 6 antibody Bcl 6 antibody BCL-5 antibody BCL-6 antibody cys his2 zinc finger transcription factor antibody LAZ 3 antibody Lymphoma associated zinc finger gene on chromosome 3 antibody Protein LAZ-3 antibody ZBTB 27 antibody Zinc finger and BTB domain-containing protein 27 antibody Zinc finger protein 51 antibody zinc finger transcription factor BCL6S antibody ZNF 51 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
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P-BCL6-631 | |||
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P-BCL6-631 | |||
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P-BCL6-631 | |||
|
BCL6-631-FITC | |||
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