PARD6B Positive Control

General Information

Product

PARD6B Positive Control

Description

Western Blot Positive Control Partitioning Defective 6 homolog beta Antibody

Verified Applications

WB

Physical Properties

Quantity

5 Applications

Volume

Inquire

Concentration

The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel.

Form

Western Blot Positive Control

Storage

-20?C for long term storage

Protein

Uniprot #

Q9BYG5

Overview

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Molecular Function

protein kinase C binding

Rho GTPase binding

Subcellular Location

Cell membrane, Cytoplasm

Expression

Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.

Structure

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.

The PDZ domain mediates interaction with MPP5.

Alternative Nomenclature

OTTHUMP00000031269 antibody

PAR 6 beta antibody

Par 6 partitioning defective 6 homolog beta (C. elegans) antibody

PAR6B antibody

PARD6 beta antibody

PARD6B antibody

partitioning defective 6 homolog beta antibody

partitioning-defective protein 6, C. elegans, homolog of, beta antibody