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General Information
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Product
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RIPK3 Western Blot Positive Control
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Description
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Western Blot Positive Control Receptor-interacting Serine/Threonine-protein kinase 3 Antibody C-epitope
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| Species |
Human |
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Verified Applications
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WB
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Accession #
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NCBI: NP_006862.2
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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| Concentration |
The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel. |
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Form
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Western Blot Positive Control
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Protein
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Uniprot #
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Q9Y572
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Overview
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Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Cell membrane, Mitochondrion
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Expression
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Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
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Structure
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Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
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Alternative Nomenclature
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Receptor interacting protein 3 antibody
Receptor interacting serine threonine kinase 3 antibody
Receptor-interacting protein 3 antibody
RIP 3 antibody
RIP like protein kinase 3 antibody
RIPK 3 antibody
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RIPK3 Antibody
RIPK3 Antibody BIOTIN
RIPK3 Blocking Peptide
RIPK3 Blocking Peptide
RIPK3 Antibody
RIPK3 Antibody FITC
RIPK3 Antibody FITC
RIPK3 Antibody BIOTIN
