PDE12 Antibody

Product no.: PD12-101AP

$285.00

Description

General Information
Product	PDE12 Antibody
Description	Affinity Purified Phosphodiesterase 12 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 370-420 on rat PDE12 protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunohistochemistry	1:50-1:100
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q6TUH0
Overview	Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Molecular Function	Metal ion binding; poly (A)-specific ribonuclease activity
Subcellular Location	Mitochondrion Matrix
Expression	Ubiquitous
Structure	Belongs to the CCR4/nocturin family.
Alternative Nomenclature	2 PDE antibody 2' 5' phosphodiesterase 12 antibody 2' phosphodiesterase antibody 2'-PDE antibody DKFZp667B1218 antibody Pde12 antibody Phosphodiesterase 12 antibody

Protein information supplied by UniProt