PDE12 Antibody

Product no.: PD12-101AP
$265.00


General Information

 

 

Product

 

PDE12 Antibody

Description

Affinity Purified Phosphodiesterase 12 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 370-420 on rat PDE12 protein.


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:10,000

Immunohistochemistry 1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500


Protein

 

Uniprot #

 

Q6TUH0

Overview

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Molecular Function

Metal ion binding; poly (A)-specific ribonuclease activity

Subcellular Location

Mitochondrion Matrix

Expression

Ubiquitous

Structure

Belongs to the CCR4/nocturin family.

Alternative Nomenclature

2 PDE antibody

2' 5' phosphodiesterase 12 antibody

2' phosphodiesterase antibody

2'-PDE antibody

DKFZp667B1218 antibody

Pde12 antibody

Phosphodiesterase 12 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
PDE12 Antibody FITC PDE12 Antibody FITC
PD12-FITC $350.00 *
PDE12 Antibody BIOTIN PDE12 Antibody BIOTIN
PD12-BIOTIN $350.00 *
PDE12 Blocking Peptide PDE12 Blocking Peptide
P-PD12 $145.00 *
PDE12 Positive Control PDE12 Positive Control
PC-PD12 $185.00 *
Display accessory details

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