PDE2A2 Antibody

General Information

Product

PDE2A2 Antibody

Description

Affinity Purified Phosphodiesterase 2A2 Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A2 protein.

Accession #

NCBI:  NP_001230713.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding

Subcellular Location

Mitochondrion matrix

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 2