PDE2A4 Antibody

General Information

Product

PDE2A4 Antibody

Description

Affinity Purified cGMP-dependent 3',-5'-cyclic phosphodiesterase isoform PDE2A4 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human PDE2A4 protein.

Accession #

NCBI: NP_001139681.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.  Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Molecular Function

Hydrolase, calcium channel activity, cAMP binding

Subcellular Location

Isoform PDE2A3: Cell membrane; Lipid-anchor, Isoform PDE2A2: Mitochondrion matrix, Isoform PDE2A1: Cytoplasm, Isoform 5: Mitochondrion

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Homodimer

Alternative Nomenclature

5''-cyclic phosphodiesterase antibody

cGMP dependent 3'5' cyclic phosphodiesterase antibody

cGMP stimulated phosphodiesterase 1 antibody

cGMP stimulated phosphodiesterase 4 antibody

cGMP-dependent 3'' antibody

CGS PDE antibody

Cyclic GMP stimulated phosphodiesterase antibody

Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase antibody

PDE 2A antibody

PDE 2A4 antibody

Phosphodiesterase 2A cGMP stimulated antibody