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General Information
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Product
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Profilin Antibody
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Description
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Affinity Purified Profilin 1 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to amino acids within region 50-100 on human Profilin 1.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20?C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500-1:5,000
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Protein
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Uniprot #
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P07737
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Overview
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Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
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Molecular Function
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actin binding
actin monomer binding
adenyl-nucleotide exchange factor activity
cadherin binding
phosphatidylinositol-4,5-bisphosphate binding
phosphotyrosine residue binding
proline-rich region binding
RNA binding
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Subcellular Location
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cytoskeleton
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Expression
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Expressed in epididymis (at protein level).
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Alternative Nomenclature
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Actin binding protein antibody
ALS18 antibody
Epididymis tissue protein Li 184a antibody
OTTHUMP00000125244 antibody
PFN 1 antibody
Pfn antibody
PFN1 antibody
PROF1_HUMAN antibody
Profilin I antibody
Profilin1 antibody
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Profilin Antibody BIOTIN
Profilin Blocking Peptide
Profilin Antibody FITC
Profilin Positive Control
