Profilin Antibody

General Information

Product

Profilin Antibody

Description

Affinity Purified Profilin 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region 50-100 on human Profilin 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20?C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000

Protein

Uniprot #

P07737

Overview

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.

Molecular Function

actin binding

actin monomer binding

adenyl-nucleotide exchange factor activity

cadherin binding

phosphatidylinositol-4,5-bisphosphate binding

phosphotyrosine residue binding

proline-rich region binding

RNA binding

Subcellular Location

cytoskeleton

Expression

Expressed in epididymis (at protein level).

Alternative Nomenclature

Actin binding protein antibody

ALS18 antibody

Epididymis tissue protein Li 184a antibody

OTTHUMP00000125244 antibody

PFN 1 antibody

Pfn antibody

PFN1 antibody

PROF1_HUMAN antibody

Profilin I antibody

Profilin1 antibody