General Information |
|
Product |
Somatostatin Receptor 2 Antibody FITC |
Description |
FITC-Conjugated Somatostatin receptor type 2 / SSTR2 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 300-350 on human Somatostatin receptor type 2 / SSTR2. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. |
Molecular Function |
G protein-coupled receptor activity Source: GO_Central neuropeptide binding Source: GO_Central PDZ domain binding Source: UniProtKB peptide binding Source: GO_Central somatostatin receptor activity |
Subcellular Location |
Cell membrane, Cytoplasm, Membrane |
Expression |
Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the |
Structure |
Transmembrane, Transmembrane helix |
Alternative Nomenclature |
Somatostatin receptor type 2 antibody SRIF-1 antibody SS-2-R antibody SS2R antibody SST2 antibody SSTR2 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
SSTR2-101AP | |||
|
SSTR2-BIOTIN | |||
|
P-SSTR2 | |||
|
PC-SSTR2 | |||
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