General Information |
|
Product |
ZFP36L2 Antibody FITC |
Description |
FITC-Conjugated Zinc finger protein 36, C3H1 type-like 2 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid reigon 350-400 on human Zinc finger protein 36, C3H1 type-like 2. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation. |
Molecular Function |
AU-rich element binding, DNA binding, metal ion binding, mRNA 3'-UTR AU-rich region binding, poly(A) RNA binding, transcription factor activity, sequence-specific DNA binding |
Subcellular Location |
Cytoplasm, Nucleus |
Structure |
Repeat, Zinc-finger |
Alternative Nomenclature |
BRF2 antibody Butyrate response factor 2 antibody C3H1 type-like 2 antibody EGF response factor 2 antibody ERF 2 antibody Protein TIS11D antibody RNF162C antibody TIS11D antibody ZFP36 like 2 antibody ZFP36 ring finger protein like 2 antibody Zinc finger protein 36 antibody Zinc finger protein 36, C3H type like 1 antibody zinc finger protein 36, C3H type like 2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ZFP36L2-201AP | |||
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ZFP36L2-BIOTIN | |||
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P-ZFP36L2 | |||
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PC-ZFP36L2 | |||
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