General Information

Product

ADCY5 Antibody

Description

Affinity Purified Adenylyl cyclase type 5 mRNA Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on rat Particulate Adenylyl Cyclase 5 protein.

Accession #

GenBank: M96159.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200-1:1,000

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200-1:1,000

Immunofluorescence

1:200-1:1,000

Immunohistochemistry

1:200-1:1,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q04400

Overview

Membrane bound calcium-inhibitable adenylyl cyclase.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane protein; Cell projection; cilium

Structure

Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2.  Interacts with RAF1.

Alternative Nomenclature

AC 5 antibody

Adcy5 antibody

Adenylate cyclase type V antibody

Adenylyl cyclase 5 antibody

ATP pyrophosphate-lyase 5 antibody

General Information

Product

ADCY6 Antibody

Description

Affinity Purified Adenylate cyclase type 6 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH.

Sequence:

DERKTAWGERNGQKR

Accession #

GenBank: AAD29856.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100-1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100-1:200

Immunofluorescence

1:100-1:200

Immunohistochemistry

1:100-1:200

Western Blot

1:500

Protein

Uniprot #

Q03343

Overview

Membrane bound calcium-inhibitable adenylyl cyclase.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane protein; Cell projection; cilium

Structure

Part of a complex containing AKAP5, ADCY5, PDE4C, PKD2. Interacts with RAF1.

Alternative Nomenclature

AC6 

ACVI 

ADCYB 

Adenylate cyclase 6 

ATP pyrophosphate-lyase 6 

Ca(2+) inhibitable adenylyl cyclase 

EC 4.6.1.1 

KIAA0422 

General Information

Product

ADCY7 Antibody

Description

Affinity Purified Particulate Adenylate cyclase type 7 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on mouse Particulate Adenylyl Cyclase 7 protein.

Accession #

NCBI:  NP_031432.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100-1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100-1:200

Immunofluorescence

1:100-1:200

Immunohistochemistry

1:100-1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P51829

Overview

Membrane bound calcium-inhibitable adenylyl cyclase.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane

Expression

Heart, spleen and lung

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.  Contains 2 guanylate cyclase domains.

Alternative Nomenclature

adenylate cyclase 7 antibody

adenylyl cyclase antibody

ATP pyrophosphate-lyase antibody

KIAA0037 antibody

General Information

Product

ADCY8 Antibody

Description

Affinity Purified Particulate adenylate cyclase 8 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human Particulate Adenylyl Cyclase 8 protein.

Accession #

GenBank:  AAZ13596.1

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q4F7X0

Overview

Involved in intracellular signal transduction and adenylate cyclase activity.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Integral component of membrane

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Alternative Nomenclature

ADCY3 antibody

ATP pyrophosphate-lyase 8 antibody

Brain adenylate cyclase 8 antibody

Ca(2+)/calmodulin activated adenylyl cyclase antibody

HBAC1 antibody

General Information

Product

ADCY9 Antibody Affinity Purified

Description

Affinity Purified Adenylate cyclase type 9 Antibody

Verified Applications

ELISA, WB; predicted to work with:  CM, ICC, IHC, IF

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60503

Overview

Plays role in interplay between intracellular calcium and cAMP.  Docking site for calcineurin.

Molecular Function

Adenylate cyclase activity; metal ion binding; ATP binding

Subcellular Location

Axon; dendrite; integral component of plasma membrane

Expression

Expressed in lung cells, airway smooth muscle

Structure

Adenylyl cyclase class-4/guanylyl cyclase family.  Contains 2 guanylate cyclase domains.

Alternative Nomenclature

ATP pyrophosphate lyase 9 antibody

KIAA0520 antibody

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

General Information

Product

AGE Antibody

Description

Affinity Purified Advance Glycated Endproduct Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Overview

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Molecular Function

Inflammatory Response

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Secreted

Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein

Expression

Endothelial cells.

Structure

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

Alternative Nomenclature

Advanced glycation end products antibody

AGEs antibody

General Information

Product

AKR1B1 Antibody

Description

Affinity Purified Aldo-keto reductase family 1, member B1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 250-350 on human Aldo-keto reductase family 1, member B1 protein.

Accession #

GenBank: AAH05387.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P15121

Overview

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Molecular Function

Aldo-keto reductase (NADP) activity, glyceraldehyde oxidoreductase activity, electron carrier activity

Subcellular Location

Cytoplasm

Expression

Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.

Structure

Monomer

Alternative Nomenclature

ADR 

AKR1B 1 

Aldehyde reductase 

Aldo keto reductase family 1, member B1 

Aldose reductase 

aldr 1 

ALR2 

AR 

Lii5 2 CTCL tumor antigen 

low Km aldose reductase 

General Information

Product

BCKDH Antibody

Description

Affinity Purified Branched chain a-ketoacid dehydrogenase kinase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 170-200 on human BCKD protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O14874

Overview

Catalyzes phosphorylation and inactivation of branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine.

Molecular Function

Kinase; Transferase; ATP-binding; Nucleotide-binding

Subcellular Location

Mitochondrion Matrix

Expression

Ubiquitious

Structure

Belongs to the PDK/BCKDK protein kinase family. Contains 1 histidine kinase domain.

Alternative Nomenclature

[3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial antibody

mitochondrial antibody

General Information

Product

Bestrophin 2 Antibody

Verified Applications

CM, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 388-404 of Mouse Bestrophin 2 protein, peptide was covalently modified.

Sequence:

EVHGDFLQRLLPAGAGS

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8BGM5

Overview

Forms calcium sensitive chloride channels. Highly permeable to bicarbonate.

Molecular Function

Ion transport; Sensory transduction; Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Retinal pigment epithelium and colon

Structure

Belongs to Bestrophin Family

Alternative Nomenclature

BEST 2 antibody

Vitelliform macular dystrophy 2 homolog antibody

Vitelliform macular dystrophy 2 like 1 antibody

VMD2L1 antibody

General Information

Product

ANT2 Antibody

Description

Affinity Purified ADP/ATP Translocase 2 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on human ADP/ATP translocase 2.

Sequence:

AER EFR GLG DCL VKI YKS DGI KGL YQG FNV SVQ GII IYR AAY FGI YDT AK

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500. Molecular Weight: 33-36 kDa.

Protein

Uniprot #

P05141

Overview

Catalyzes exchange of cytoplasmic ADP with mitochondrial ATP across mitochondrial inner membrane.  May also play role in chromosome segregation.

Molecular Function

Chromosome partition; Host-virus interaction; Transport

Subcellular Location

Mitochondrion inner membrane; multipass membrane protein

Structure

Homodimer, Component of MMXD complex.

Alternative Nomenclature

2F1 antibody

AAC2 antibody

Adenine nucleotide translocator 2 antibody

ADP antibody

ADP ATP carrier protein 2 antibody

ANT2 antibody

ATP carrier protein 2 antibody

fibroblast isoform antibody

SLC25A5 antibody

Solute carrier family 25 member 5 antibody

T2 antibody

T3 antibody