General Information

Product

Indoleamine 2, 3-dioxygenase 1 Antibody

Description

Affinity Purified Indoleamine 2,3-dioxygenase 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human Indoleamine 2,3-dioxygenase 1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P14902

Subcellular Location

cytosol

Expression

Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885).

Structure

Belongs to the indoleamine 2,3-dioxygenase family.

Alternative Nomenclature

3-dioxygenase antibody

I23O1_HUMAN antibody

IDO antibody

IDO1 antibody

INDO antibody

indolamine 2,3 dioxygenase antibody

Indole 2 3 dioxygenase antibody

indoleamine 2 3 dioxygenase 1 antibody

indoleamine 2 3 dioxygenase antibody

Indoleamine 2,3-dioxygenase 1 antibody

Indoleamine pyrrole 2 3 dioxygenase antibody

Indoleamine-pyrrole 2 antibody

General Information

Product

IRAK1 Antibody

Description

Affinity Purified Interleukin-1 receptor-associated kinase 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid reigon 700-750 on mouse Interleukin-1 receptor-associated kinase 1 protein.

Accession #

NCBI:  NP_001171444

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polylclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

B1AUW6

Molecular Function

ATP binding

heat shock protein binding

kinase activity

NF-kappaB-inducing kinase activity

protein heterodimerization activity

protein homodimerization activity

protein kinase activity

protein serine/threonine kinase activity

Subcellular Location

Nucleus, Cytoplasm, Lipid droplet

Expression

Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.

Structure

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Alternative Nomenclature

Il1rak antibody

Interleukin 1 receptor associated kinase 1 antibody

IRAK antibody

Irak1 antibody

mPLK antibody

Pelle antibody

Pelle homolog antibody

Plpk antibody

General Information

Product

TNF alpha Antibody

Description

Affinity Purified Tumor necrosis factor alpha Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids within region 100-150 on human Tumor necrosis factor alpha protein.

Physical Properties

Quantity

100 µg

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Conjugate

Unconjugated

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:50-1:100

Immunofluorescence

1:50-1:100

Immunohistochemistry

1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P01375

Molecular Function

cytokine activity

identical protein binding

protease binding

transcription cis-regulatory region binding

tumor necrosis factor receptor binding

Subcellular Location

Extra cellular secreted, plasma membrane

Structure

Signal-anchor, Transmembrane, Transmembrane helix

Alternative Nomenclature

APC1 antibody

Cachectin antibody

DIF antibody

Differentiation inducing factor antibody

Macrophage cytotoxic factor antibody

Tnf antibody

TNF superfamily member 2 antibody

TNF, macrophage derived antibody

TNF, monocyte derived antibody

TNF-a antibody

TNF-alpha antibody

TNFA antibody

TNFA_HUMAN antibody

TNFSF2 antibody

Tumor necrosis factor (TNF superfamily member 2) antibody

Tumor necrosis factor alpha antibody

Tumor necrosis factor antibody

Tumor necrosis factor ligand superfamily member 2 antibody

Tumor Necrosis Factor, Membrane Form antibody

Tumor necrosis factor, soluble form antibo