General Information

Product

CRMP3 Antibody

Description

Affinity Purified Dihydropyrimidinase related protein 4 Antibody

Verified Applications

ELISA, WB

Species Cross Reactivity

Cat, Human, Monkey, Mouse, Pig, Rat

Immunogen

Synthetic peptide corresponding to amino acids 509-527 of Mouse CRMP3. The peptide was covalently modified to achieve the desired antigenicity before coupling to carrier protein.

Sequence:

PAKPGSGTQARASCSGKIS

Accession #

NCBI: NP_006417.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:450

Protein

Uniprot #

O14531

Overview

Necessary for signaling by class 3 semaphorins and subsequent remodeling of cytoskeleton.  Plays a role in axon guidance, neuronal growth cone collapse and cell migration.

Molecular Function

Axon guidance; pyrimidine nucelobase catabolic process; Nervous system development

Subcellular Location

Cytoplasm

Structure

Homotetramer.

Alternative Nomenclature

Collapsin response mediator protein 3 antibody

DPYSL4 antibody

DRP4 antibody

ULIP 4 antibody

UNC33 like phosphoprotein 4 antibody

General Information

Product

Estrogen Receptor alpha Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 30-80 on human ESTRA protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P03372

Overview

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Molecular Function

Activator, Receptor

Subcellular Location

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Expression

Widely expressed. Isoform 3 is not expressed in the pituitary gland

Structure

Belongs to the nuclear hormone receptor family. NR3 subfamily

Alternative Nomenclature

DKFZp686N23123 antibody

ER alpha antibody

ER antibody

Era antibody

ESR antibody

ESR1 antibody

ESRA antibody

Estradiol receptor antibody

Estrogen nuclear receptor alpha antibody

Estrogen receptor 1 antibody

Estrogen receptor antibody

ESTRR antibody

Major ORF antibody

NR3A1 antibody

Nuclear receptor subfamily 3 group A member 1 antibody

General Information

Product

HDAC4 Antibody

Description

Affinity Purified Histone deacetylase 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1,000-1,084 on human HDAC4 protein.

Accession #

GeneBank: AAH39904

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q86YH7

Overview

Responsible for deacetylation of lysine residues on the N-terminal part of the core histones.  Histone deacetylation gives a tag for epigenetic repression and plays and important role in transcriptional regulation, cell cycle progression and developmental events.

Molecular Function

Metal-binding; Zinc

Subcellular Location

Nucleus

Structure

Belongs to the histone deacetylase family. HD type 2 subfamily

Alternative Nomenclature

AHO3 antibody

BDMR antibody

EC 3.5.1.98 antibody

HA6116 antibody

HD 4 antibody

HDAC A antibody

Histone Deacetylase A antibody

KIAA0288 antibody

General Information

Product

Histone H3 Antibody

Description

Affinity Purified Histone H3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Pedicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human HH3 protein.

Accession #

GeneBank: CAA58540.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P68431

Overview

Core component of nucleosome.Play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Molecular Function

DNA-binding

Subcellular Location

Nucleus; Chromosome

Expression

During Sphase, then expression decreases as cell division slows down during the process of differentiation

Structure

Belongs to histone H3 family

Alternative Nomenclature

H3.3B antibody

H3F3A antibody

H3 histone antibody

H3.3A antibody

H3F3 antibody

H3f3b antibody

HIST3H3 antibody

Histone H3 3 pseudogene antibody

PP781 antibody

General Information

Product

KAT13C / NCOA2 Antibody Affinity Purified

Description

Affinity Purified Nuclear receptor coactivator 2 isoform b Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid 1375-1425 on rat NuCR2/GRIP-1/SRC-2 protein.

Accession #

NCBI:  NP_001071163.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.70-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Alternative Nomenclature

bHLHe75 antibody

Class E basic helix-loop-helix protein 75 antibody

glucocorticoid receptor interacting protein 1 antibody

GRIP 1 antibody

hTIF2 antibody

MED1 antibody

MGC138808 antibody

NCoA 2 antibody

Oncogene FGR antibody

p160 antibody

SRC 2 antibody

TIF2 antibody

General Information

Product

Nurr1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. 

Sequence:

CTQGLQRIFYLKLEDLVPPPAIIDKL

Accession #

GenBank: BAA75666.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43354

Overview

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development.

Molecular Function

Receptor

Subcellular Location

Cytoplasm, Nucleus

Expression

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Structure

Belongs to the nuclear hormone receptor family. NR4 subfamily.

Alternative Nomenclature

HZF 3 antibody

Immediate-early response protein NOT antibody

NGFI B/nur77 beta type transcription factor homolog antibody

NOT antibody

NR4A2 antibody

Nur related protein 1 homolog antibody

Nurr 1 antibody

Orphan nuclear receptor NR4A2 antibody

RNR1 antibody

T cell nuclear receptor NOT antibody

TINUR antibody

Transcriptionally inducible nuclear receptor antibody

General Information

Product

RUNX1 / AML1 Antibody Affinity Purified

Description

Affinity Purified RUNX1 Protein Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-80 on human RUNX1 protein.

Accession #

GenBank: AAI36381.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.53 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q01196

Overview

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis.

Molecular Function

ATP binding, DNA binding, calcium ion binding

Subcellular Location

Nucleus

Expression

Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.

Structure

Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize.

Alternative Nomenclature

Acute myeloid leukemia 1 protein antibody

alpha subunit core binding factor antibody

AML1 EVI 1 fusion protein antibody

Aml1 oncogene antibody

AMLCR 1 antibody

CBF alpha 2 antibody

Core binding factor runt domain alpha subunit 2 antibody

Core-binding factor subunit alpha-2 antibody

EVI1 antibody

HGNC antibody

Oncogene AML 1 antibody

PEBP2 alpha B antibody

Polyomavirus enhancer binding protein 2 alpha B subunit antibody

Run1 antibody

Runt-related transcription factor 1 antibody

SL3/AKV core binding factor alpha B subunit antibody

General Information

Product

KAP1 / TRIM28 Antibody Affinity Purified

Description

Affinity Purified Tripartite motif-containing 28 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 750-834 on mouse TRIM28 protein.

Accession #

GenBank: AAH89337

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q5EBP9

Molecular Function

Chromo shadow domain binding; Krueppel-associated box domain binding; Protein kinase activity

Subcellular Location

Chromatin; Nuclear heterochromatin; Nucleus; Nuclear euchromatin; Nucleoplasm

Structure

Contains RING-type zinc finger

Alternative Nomenclature

E3 SUMO protein ligase TRIM28 antibody

KAP 1 antibody

KRAB associated protein 1 antibody

KRIP1 antibody

Nuclear corepressor KAP 1 antibody

RING finger protein 96 antibody

RNF96 antibody

TF1B antibody

TIF1 beta antibody

Transcription intermediary factor 1 beta antibody

TRIM28 antibody

Tripartite motif containing 28 antibody

General Information

Product

Phospho-Histone H3 Antibody (S10)

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Phosphorylated synthetic peptide taken within amino acid region 1-50 on HH3 protein.

Accession #

GenBank: CAA58540.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P68431

Overview

Core component of nucleosome.Play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Molecular Function

DNA-binding

Subcellular Location

Nucleus; Chromosome

Expression

During Sphase, then expression decreases as cell division slows down during the process of differentiation.

Structure

Belongs to histone H3 family

Alternative Nomenclature

H3.3B antibody

H3F3A antibody

H3 histone antibody

H3 histone family member E pseudogene antibody

HIST3H3 antibody

Histone H3 3 pseudogene antibody

PP781 antibody

General Information

Product

Histone H3 Antibody

Description

Affinity Purified Histone H3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, S. cerevisiae

Immunogen

Synthetic peptide taken within amino acid 1-50 on Sacchoromyces cerevisiae protein HH3 protein.

Accession #

Gen Bank: EDZ69636.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

B5VR08

Overview

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro).

Molecular Function

Chromatin regulator, Methyltransferase, Transferase

Subcellular Location

Nucleus

Structure

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

Contains 1 DOT1 domain.

Alternative Nomenclature

H3 histone family, member J antibody

H3 histone antibody

H3 histone family, member A antibody

H3 histone family, member B antibody

H3 histone family, member C antibody

H3 histone family, member D antibody

H3 histone family, member F antibody

H3 histone family, member H antibody

H3 histone family, member I antibody

H3 histone family, member K antibody

H3 histone family, member L antibody

H3 histone, family 3A antibody

H3.3A antibody

H3F1K antibody

H3F3 antibody

Histone cluster 1, H3a antibody

Histone cluster 1, H3b antibody

Histone cluster 1, H3c antibody

Histone cluster 1, H3d antibody

Histone cluster 1, H3e antibody

Histone cluster 1, H3f antibody

Histone cluster 1, H3g antibody

Histone cluster 1, H3i antibody

Histone cluster 1, H3j antibody