General Information

Product

AGE Antibody

Description

Affinity Purified Advance Glycated Endproduct Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Overview

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Molecular Function

Inflammatory Response

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Secreted

Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein

Expression

Endothelial cells.

Structure

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

Alternative Nomenclature

Advanced glycation end products antibody

AGEs antibody

General Information

Product

ANT2 Antibody

Description

Affinity Purified ADP/ATP Translocase 2 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on human ADP/ATP translocase 2.

Sequence:

AER EFR GLG DCL VKI YKS DGI KGL YQG FNV SVQ GII IYR AAY FGI YDT AK

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500. Molecular Weight: 33-36 kDa.

Protein

Uniprot #

P05141

Overview

Catalyzes exchange of cytoplasmic ADP with mitochondrial ATP across mitochondrial inner membrane.  May also play role in chromosome segregation.

Molecular Function

Chromosome partition; Host-virus interaction; Transport

Subcellular Location

Mitochondrion inner membrane; multipass membrane protein

Structure

Homodimer, Component of MMXD complex.

Alternative Nomenclature

2F1 antibody

AAC2 antibody

Adenine nucleotide translocator 2 antibody

ADP antibody

ADP ATP carrier protein 2 antibody

ANT2 antibody

ATP carrier protein 2 antibody

fibroblast isoform antibody

SLC25A5 antibody

Solute carrier family 25 member 5 antibody

T2 antibody

T3 antibody

General Information

Product

Aquaporin 1 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 215-265 on human Aquaporin 1 protein.

Accession #

GenBank:  AAL87136

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.59 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P29972

Overview

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Molecular Function

Blood group antigen; Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.

Structure

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Alternative Nomenclature

AQP 1 antibody

AQP CHIP antibody

aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group) antibody

Aquaporin CHIP antibody

Aquaporin-1 antibody

Channel forming integral protein 28kDa antibody

Channel like integral membrane protein 28 kDa antibody

CHIP 28 antibody

CO antibody

Colton blood group antibody

Growth factor induced delayed early response protein antibody

MGC26324 antibody

Urine water channel antibody

Water channel protein CHIP 29 antibody

Water channel protein for red blood cells and kidney proximal tubule antibody

General Information

Product

Aquaporin 3 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on rat Aquaporin 3 protein.

Accession #

GenBank: CAG46822.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.57 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P47862

Overview

Promotes glycerol permeability and water transport across cell membranes.  Plays important role in regulating stratum corneum and epidermal glyceral content.  Involved in skin hydration, wound healing and tumorigenesis.

Molecular Function

Transport

Subcellular Location

Membrane; Multi-pass protein

Expression

Renal medulla and colon.

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

AQP 3 antibody

Aquaglyceroporin-3 antibody

Aquaporin 3 (GIL blood group) antibody

Aquaporin-3 antibody

GIL antibody

Gill blood group antibody

General Information

Product

Aquaporin 6 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 220-270 on rat Aquaporin 6 protein.

Accession #

NCBI:  NP_071517.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:400

Protein

Uniprot #

Q9WTY0

Overview

Forms water specific channel.  Invovled in several physiological functions including glomerular filtration, tubular endocytosis, and acid-base metabolism

Molecular Function

Transport

Subcellular Location

Cytoplasmic vessicle membrane; Multi-pass membrane protein

Expression

Kidney

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

AQP-6 antibody

AQP2L antibody

Aquaporin 2 like antibody

aquaporin 2 like kidney specific antibody

Aquaporin 6 antibody

Aquaporin 6 kidney specific antibody

hKID antibody

Human kidney water channel (hKID) mRNA, complete cds antibody

KID antibody

Kidney-specific aquaporin antibody

General Information

Product

ARHGEF7 Antibody

Description

Affinity Purified Rho-guanine nucleotide exchange factor 7 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q14155

Overview

Acts as RAC1 guanine nucleotide exchange factor and can induce membrane ruffling.

Molecular Function

Neurogenesis

Subcellular Location

Cell junction; foacl adhesion; Cell projection ruffle; Cell cortex

Structure

Interacts with PAK kinases through SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1.

Alternative Nomenclature

ARHG7 antibody

Beta pix antibody

COOL1 antibody

Nbla10314 antibody

P50 antibody

p85 antibody

P85SPR antibody

PAK interacting exchange factor beta antibody

PAK3 antibody

SH3 domain containing proline rich protein antibody

General Information

Product

CCR2 Antibody

Description

Affinity Purified C-C chemokine receptor type 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 20-70 on human CCR2 protein.

Accession #

NCBI: NP_955783

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P41597

Overview

Receptor for CCL2, CCL7 and CCL13 chemokines.  Transduces a signal by increasing intracellular calcium ion levels.  Alternative coreceptor with CD4 for HIV-1 infection.

Molecular Function

Host-virus interaction; GPCR; Transducer

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

Induced; Up-regulated by CREB3

Structure

Binds to HIV-1 Tat.  Interacts with ARRB1

Alternative Nomenclature

CC CKR 2 antibody

CD192 antibody

CKR2A antibody

CKR2B antibody

CMKBR2 antibody

MCP1 RECEPTOR antibody

Monocyte chemoattractant protein 1 receptor antibody

General Information

Product

C3Orf34 Antibody

Description

Affinity Purified Chromosome 3 orf 34 Antibody

Verified Applications

DB, ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 120-170 on human Chromosome open reading frame 34 protein.

Accession #

NCBI: AAH07827

Physical Properties

Quantity

100 µg

Volume

200 µl

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q96LK0

Molecular Function

Cell projection, Cytoplasm, Cytoskeleton

Structure

Belongs to the CEP19 Family

Alternative Nomenclature

Chromosome 3 open reading frame 34 antibody

HSD5 antibody

LOC84984 antibody

MGC14126 antibody

General Information

Product

CD36 Antibody Affinity Purified

Description

Affinity Purified platelet glycoprotein 4 isoform 1 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human CD36 protein.

Accession #

NCBI:  NP_001120916.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P16671

Overview

Involved in binding to collagen, thrombospodin, anionic phospholipids and oxidized low density lipoprotein.  Serves to bind long chain fatty acids and  also may act as a cell adhesion molecule, or regulator of fatty acid transport.

Molecular Function

Lipoprotein particle binding; thrombospondin receptor activity; Receptor

Subcellular Location

Membrane; Multipass membrane protein

Structure

Interacts with THBS1 and THBS2, mediating THBS antiangiogenic activity.

Alternative Nomenclature

Adipocyte membrane protein antibody

thrombospondin receptor) antibody

cd36 antigen antibody

CHDS7 antibody

Cluster determinant 36 antibody

Collagen receptor, platelet antibody

FAT antibody

fatty acid translocase antibody

glycoprotein iiib antibody

GP IIIb antibody

gp4 antibody

gpiv antibody

leukocyte differentiation antigen cd36 antibody

PAS 4 protein antibody

platelet collagen receptor antibody

scarb3 antibody

Scavenger receptor class B member 3 antibody

thrombospondin receptor antibody

General Information

Product

CXCR4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 15-65 on CXCR4 protein.

Accession #

GenBank:  CAA12166

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P61073

Overview

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Molecular Function

Host-virus Interaction

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome

Expression

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Structure

Monomer. Can form dimers.

Alternative Nomenclature

C-X-C chemokine receptor type 4 antibody

CD184 antibody

Chemokine CXC Motif Receptor 4 antibody

CXCR4 antibody

D2S201E antibody

FB22 antibody

Fusin antibody

HM89 antibody

HSY3RR antibody

LAP 3 antibody

LCR1 antibody

LESTR antibody

Leukocyte derived seven transmembrane domain receptor antibody

Lipopolysaccharide associated protein 3 antibody

Neuropeptide Y receptor Y3 antibody

NPY3R antibody

NPYR antibody

NPYRL antibody

Probable G protein coupled receptor lcr1 homolog antibody

SDF 1 receptor antibody

Stromal cell derived factor 1 receptor antibody

WHIM antibody