General Information

Product

ADCY8 Antibody

Description

Affinity Purified Particulate adenylate cyclase 8 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human Particulate Adenylyl Cyclase 8 protein.

Accession #

GenBank:  AAZ13596.1

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q4F7X0

Overview

Involved in intracellular signal transduction and adenylate cyclase activity.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Integral component of membrane

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Alternative Nomenclature

ADCY3 antibody

ATP pyrophosphate-lyase 8 antibody

Brain adenylate cyclase 8 antibody

Ca(2+)/calmodulin activated adenylyl cyclase antibody

HBAC1 antibody

General Information

Product

ADCY9 Antibody Affinity Purified

Description

Affinity Purified Adenylate cyclase type 9 Antibody

Verified Applications

ELISA, WB; predicted to work with:  CM, ICC, IHC, IF

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60503

Overview

Plays role in interplay between intracellular calcium and cAMP.  Docking site for calcineurin.

Molecular Function

Adenylate cyclase activity; metal ion binding; ATP binding

Subcellular Location

Axon; dendrite; integral component of plasma membrane

Expression

Expressed in lung cells, airway smooth muscle

Structure

Adenylyl cyclase class-4/guanylyl cyclase family.  Contains 2 guanylate cyclase domains.

Alternative Nomenclature

ATP pyrophosphate lyase 9 antibody

KIAA0520 antibody

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

General Information

Product

AGE Antibody

Description

Affinity Purified Advance Glycated Endproduct Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Overview

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Molecular Function

Inflammatory Response

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Secreted

Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein

Expression

Endothelial cells.

Structure

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

Alternative Nomenclature

Advanced glycation end products antibody

AGEs antibody

General Information

Product

AKR1B1 Antibody

Description

Affinity Purified Aldo-keto reductase family 1, member B1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 250-350 on human Aldo-keto reductase family 1, member B1 protein.

Accession #

GenBank: AAH05387.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P15121

Overview

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Molecular Function

Aldo-keto reductase (NADP) activity, glyceraldehyde oxidoreductase activity, electron carrier activity

Subcellular Location

Cytoplasm

Expression

Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.

Structure

Monomer

Alternative Nomenclature

ADR 

AKR1B 1 

Aldehyde reductase 

Aldo keto reductase family 1, member B1 

Aldose reductase 

aldr 1 

ALR2 

AR 

Lii5 2 CTCL tumor antigen 

low Km aldose reductase 

General Information

Product

ASNA1 Antibody

Description

Affinity Purified Arsenate activated ATPase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-348 on human ATPase ASNA1 protein.

Accession #

NCBI:  NP_004308

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-.53 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43681

Overview

ATPase required for post-translational delivery of tail-anchored proteins to the ER

Molecular Function

ATP binding; Metal-binding; Nucleotide binding; Zinc

Subcellular Location

Cytoplasm; Endoplasmic Reticulum; Nucleus

Expression

Epithelial cells of liver, kidney, stomach wall, islet cells of pancreas, red pulp of spleen and cardiac and skeletal muscle.

Structure

Homodimer. Component of transmembrane domain recognition complex.

Alternative Nomenclature

ARSA 1 antibody

ArsA arsenite transporter ATP binding homolog 1 antibody

GET3 antibody

Golgi to ER traffic 3 homolog antibody

Transmembrane domain recognition complex, 40kDa antibody

TRC40 antibody

General Information

Product

Bestrophin 2 Antibody

Verified Applications

CM, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 388-404 of Mouse Bestrophin 2 protein, peptide was covalently modified.

Sequence:

EVHGDFLQRLLPAGAGS

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8BGM5

Overview

Forms calcium sensitive chloride channels. Highly permeable to bicarbonate.

Molecular Function

Ion transport; Sensory transduction; Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Retinal pigment epithelium and colon

Structure

Belongs to Bestrophin Family

Alternative Nomenclature

BEST 2 antibody

Vitelliform macular dystrophy 2 homolog antibody

Vitelliform macular dystrophy 2 like 1 antibody

VMD2L1 antibody

General Information

Product

ANT2 Antibody

Description

Affinity Purified ADP/ATP Translocase 2 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on human ADP/ATP translocase 2.

Sequence:

AER EFR GLG DCL VKI YKS DGI KGL YQG FNV SVQ GII IYR AAY FGI YDT AK

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500. Molecular Weight: 33-36 kDa.

Protein

Uniprot #

P05141

Overview

Catalyzes exchange of cytoplasmic ADP with mitochondrial ATP across mitochondrial inner membrane.  May also play role in chromosome segregation.

Molecular Function

Chromosome partition; Host-virus interaction; Transport

Subcellular Location

Mitochondrion inner membrane; multipass membrane protein

Structure

Homodimer, Component of MMXD complex.

Alternative Nomenclature

2F1 antibody

AAC2 antibody

Adenine nucleotide translocator 2 antibody

ADP antibody

ADP ATP carrier protein 2 antibody

ANT2 antibody

ATP carrier protein 2 antibody

fibroblast isoform antibody

SLC25A5 antibody

Solute carrier family 25 member 5 antibody

T2 antibody

T3 antibody

General Information

Product

Aquaporin 1 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 215-265 on human Aquaporin 1 protein.

Accession #

GenBank:  AAL87136

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.59 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P29972

Overview

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Molecular Function

Blood group antigen; Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.

Structure

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Alternative Nomenclature

AQP 1 antibody

AQP CHIP antibody

aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group) antibody

Aquaporin CHIP antibody

Aquaporin-1 antibody

Channel forming integral protein 28kDa antibody

Channel like integral membrane protein 28 kDa antibody

CHIP 28 antibody

CO antibody

Colton blood group antibody

Growth factor induced delayed early response protein antibody

MGC26324 antibody

Urine water channel antibody

Water channel protein CHIP 29 antibody

Water channel protein for red blood cells and kidney proximal tubule antibody

General Information

Product

Aquaporin 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human Aquaporin 2 protein.

Accession #

GenBank: CAG46821.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.62 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P34080

Overview

Forms a water-specific channel that provies the plasma mebranes of red cells and kidney proximal tubules with water permeability.

Molecular Function

Transport

Subcellular Location

Apical cell membrane; Multiplass membrane protein; Basolateral cell membrane

Expression

Renal collecting tubule

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

ADH water channel antibody

AQP 2 antibody

AQP CD antibody

Aquaporin 2 collecting duct antibody

Aquaporin CD antibody

Collecting duct water channel protein antibody

MGC34501 antibody

Water channel aquaporin 2 antibody

Water channel protein for renal collecting duct antibody

WCH CD antibody

General Information

Product

Aquaporin 4 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-323 on rat Aquaporin 4 protein.

Accession #

NCBI:  NP_001641

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.62 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P55087

Overview

Forms water specific channel. Osmoreceptor which regulates water balance and mediates water flow within CNS.

Molecular Function

Transport

Subcellular Location

Membrane; Multi-pass protein

Expression

Abundant in mature brain but only weakly detectable in eye, kidney, intestine, and lung.

Structure

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Alternative Nomenclature

AQP 4 antibody

Aquaporin type 4 antibody

Aquaporin-4 antibody

HMIWC2 antibody

Mercurial insensitive water channel antibody

MGC22454 antibody

MIWC antibody

WCH 4 antibody