General Information

Product

EHD1 Antibody

Description

Affinity Purified EH domain-containing protein 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken wtihin amino acid region 515-565 on human EH-domain containing protein 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9H4M9

Overview

Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Plays a role in myoblast fusion. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth.

Molecular Function

Rab GTPase binding; ATP binding; calcium ion binding

Subcellular Location

Cell membrane, Endosome, Membrane

Expression

testis

Structure

Homooligomer, and heterooligomer with EHD2, EHD3 and EHD4, ATP-binding is required for heterooligomerization.

Alternative Nomenclature

CDABP0131 antibody

EH domain containing 1 antibody

FLJ42622 antibody

FLJ44618 antibody

H PAST antibody

PAST antibody

PAST1 antibody

Testilin antibody

General Information

Product

IP3 receptor Antibody Affinity Purified

Description

Affinity Purified Inositol 1,4,5-trisphosphate receptor type  isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human ITPR subtype 1 protein.

Accession #

NCBI:  NP_001093422.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q14643

Overview

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Molecular Function

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression

Widely expressed

Structure

Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channe

Alternative Nomenclature

5-trisphosphate receptor antibody

DKFZp313N1434 antibody

inositol 1 4 5 triphosphate receptor type 1 antibody

Inositol 1 antibody

InsP3R1 antibody

IP3 antibody

IP3 receptor antibody

IP3R1 antibody

ITPR 1 antibody

SCA15 antibody

SCA16 antibody

SCA29 antibody

Type 1 inositol 1 4 5 trisphosphate receptor antibody

Type 1 inositol 1 antibody

General Information

Product

NTAL Antibody

Description

Affinity Purified Linker for activation of T-cells family member 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 40-90 on LAT2 protein.

Accession #

NCBI:  NP_115852

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9GZY6

Overview

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells.

Molecular Function

SH2 domain binding

Subcellular Location

Cell membrane; Single-pass type III membrane protein

Expression

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

Structure

When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.

Alternative Nomenclature

HSPC046 antibody

LAB antibody

LAT2 antibody

Linker for activation of B cells antibody

Membrane associated adapter molecule antibody

Non T cell activation linker antibody

WBSCR 5 antibody

Wbscr15 antibody

General Information

Product

Neurochondrin Antibody 

Description

NORBIN Antibody

Verified Applications

ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on rat NORBIN protein.

Accession #

GenBank: BAA22938.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1;10,000

ELISA

1;10,000

Western Blot

1:500

Protein

Uniprot #

O35095

Overview

Involved in regulation of neuronal synaptic plasticity;neuron projection development;bone resorption

Subcellular Location

Cell projection, Cytoplasm,somatic regions of neurons

Expression

Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites.

Structure

Belongs to the neurochondrin family.

Alternative Nomenclature

AU042419 antibody

KIAA0607 antibody

M-Sema F-associating protein of 75 kDa antibody

MGC93259 antibody

MMS10-AE antibody

NCDN antibody

NCDN-1 antibody

NCDN-2 antibody

Neurochondrin 1 antibody

Norbin antibody

Sfap75 antibody

General Information

Product

Phospho-Annexin A2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to Human Annexin A2 protein with phosphorylated serine 12 and threonine 18 residues. Synthetic peptide was taken within amino acid region 1-50.

Accession #

GenBank: AAH52567.1 

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P07355

Overview

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Molecular Function

calcium-dependent phospholipid binding, calcium ion binding, calcium-dependent protein binding

Subcellular Location

Secreted › extracellular space › extracellular matrix › basement membrane

Structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH.

Alternative Nomenclature

Annexin A2 antibody

Annexin II antibody

Annexin II, heavy chain antibody

ANX2 antibody

ANX2L4 antibody

arylsulfatase B antibody

CAL1H antibody

Calpactin I heavy chain antibody

chromobindin 8 antibody

Epididymis secretory protein Li 270 antibody

HEL S 270 antibody

LIP2 antibody

Lipocortin II antibody

LPC2 antibody

LPC2D antibody

P36 antibody

PAP-IV antibody

placental anticoagulant protein IV antibody

Protein I antibody

General Information

Product

Phospho-CACNB2 Antibody

Description

Affinity Purified Voltage dependent L-type calcium channel subunit beta-2 Antibody

Verified Applications

Cell labeling, ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 600-655 on rat CACNB2 protein.

Accession #

NCBI: NP_446303

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8VGC3

Overview

The beta subunit of voltage-dependent calcium channel which contributes to calcium channel function by increasing peak calcium current, shifting the voltage dependencies fo activation and inactivation, modulating G-protein inhibition and controllin the alpha-1 subunit membrane targeting.

Molecular Function

Calcium; Transport; Ion transport

Subcellular Location

Cell membrane; Sacrolemma; Peripheral membrane protein, cytoplasmic side

Expression

Heart and brain.  Lower expression in lung.

Structure

L-type channel is composed of four subunits:  alpha-1, alpha-2, beta and gamma.

Alternative Nomenclature

AW060387 antibody

Ca(V) beta 2 antibody

CAB2 antibody

CAVB2 antibody

Cavbeta2 antibody

Cchb2 antibody

Lambert Eaton Myasthenic syndrome antigen antibody

MYSB antibody

General Information

Product

STIM2 Antibody Affinity Purified

Description

Affinity Purified STIM2 protein Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 600-650 on human STIM2 protein.

Accession #

Gen Bank: AAI36450.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9P246

Overview

Plays a role in mediating store-operated Ca2+ entry, a Ca2+ influx following depletion of intracellular Ca2+ stores. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations.

Molecular Function

Calcium channel regulator activity, calcium ion binding, store-operated calcium channel activity

Subcellular Location

Endoplasmic reticulum membrane, single-pass type I membrane protein. (Note: Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic retic

Expression

Expressed in all tissues and tumor cell lines examined.

Alternative Nomenclature

FLJ39527 antibody

KIAA1482 antibody

stromal interaction molecule 2 antibody

General Information

Product

Affinity Purified TPCN1 Antibody

Description

Two pore calcium channel protein 1 isoform 2 Antibody Affinity Purified

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within TMD7 and TMD8 on human TPC1 protein.

Accession #

NCBI:  NP_060371.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9ULQ1

Overview

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal and endosomal membrane.

Molecular Function

Calcium channel, Ion channel, Voltage-gated channel

Subcellular Location

Lysosome membrane; Multi-pass membrane protein, Endosome membrane; Multi-pass membrane protein

Expression

Highest expression found in the heart and kidney, and lowest expression found in the spleen.

Structure

Dimer.

Alternative Nomenclature

TPC1 antibody

TPCN 1 antibody

Two pore calcium channel protein 1 antibody

Two pore channel 1 antibody

Two pore segment channel 1 antibody

Voltage dependent calcium channel protein TPC1 antibody

General Information

Product

TRPV6 Antibody

Description

Affinity Purified Transient receptor potential cation channel, subfamily V, member 6 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken from the region within amino acids 700-732 of TRPV6 protein. The peptide was covalently modified to acheive desired antigenicity. Modified peptide was covalently coupled to a carrier protein by heterobifunctional cross linker for immunogen preparation.

Accession #

GenBank: EAW51899.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.67 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI00000380EC

Overview

Calcium selective cation channel probably involved in Ca2+ uptake in various tissues, including Ca2+ reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

Molecular Function

Calcium channel activity; Calmodulin binding

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Abundantly expressed in pancreas and placenta, and to a much lesser extend in stomach and kidney. Not detected in intestine.

Structure

Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmo

Alternative Nomenclature

ABPZF antibody

Alu binding protein with zinc finger domain antibody

Calcium channel CaT1 antibody

Calcium transport protein 1 antibody

CaT L antibody

CaT1 antibody

ecac antibody

ECaC2 antibody

Epithelial apical membrane calcium transporter/channel CaT1 antibody

Epithelial calcium channel 2 antibody

HSA277909 antibody

LP6728 antibody

NUDC antibody

Transient receptor potential cation channel subfamily V member 6 antibody

TrpV6 antibody

ZFAB antibody

General Information

Product

PBR Antibody

Description

Affinity Purified Mitochondrial benzodiazepine receptor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on 18 kDa mitochondrial benzodiazepine receptor protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.60-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P30536

Overview

Can bind protoporphyrin IX and may play a role in transport of porphyrins and heme. Promotes transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism.

Molecular Function

Benzodiazepine receptor activity, cholesterol binding

Subcellular Location

Mitochondrian membrane, Multi-pass membrane protein

Expression

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids

Alternative Nomenclature

Benzodiazapine receptor (peripheral) antibody

Benzodiazepine peripheral binding site antibody

BPBS antibody

BZRP antibody

DBI antibody

IBP antibody

Isoquinoline carboxamide-binding protein antibody

MBR antibody

mDRC antibody

Mitochondrial benzodiazepine receptor antibody

PBR antibody

PBS antibody

Peripheral benzodiazepine receptor antibody

Peripheral benzodiazepine receptor-related protein antibody

pk18 antibody

PKBS antibody

PTBR antibody

Ptbzr antibody

PTBZR02 antibody

RATPTBZR02 antibody

translocator protein (18kDa) antibody

Translocator protein antibody

TSPO antibody

Tspo1 antibody