RIPK3 Blocking Peptide

General Information

Product

RIPK3 Peptide

Description

Antigenic Blocking Peptide Receptor-interacting Serine/Threonine-protein kinase 3 Antibody C-epitope

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic Peptide

Accession #

NCBI:  NP_006862.2

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q9Y572

Overview

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Cell membrane, Mitochondrion

Expression

Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

Structure

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Alternative Nomenclature

Receptor interacting protein 3 antibody

Receptor interacting serine threonine kinase 3 antibody

Receptor-interacting protein 3 antibody

RIP 3 antibody

RIP like protein kinase 3 antibody

RIPK 3 antibody