Phospho-PDE11A Antibody (S163) Antibody

General Information

Product

Phospho-PDE11A (S163) Antibody

Description

Affinity Purified Phosphorylated PDE11A (Serine 163) Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-200 on rat PDE11A protein. Phosphorylated Ser 163.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Modification

Phosphorylated

Storage

-20C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000

Protein

Uniprot #

Q8VID6

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity).

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-GMP phosphodiesterase activity

3',5'-cyclic-nucleotide phosphodiesterase activity

cGMP binding Source: RGD

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

cyclic-nucleotide phosphod

Expression

Isoform 1 is expressed in brain, heart, kidney and liver, but not in prostate. Isoform 2 is specifically expressed in testis. Isoform 3 is expressed in various tissues including brain, lung, skeletal muscle, spleen, testis and prostate.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family.

Alternative Nomenclature

5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A antibody

cAMP and cGMP phosphodiesterase 11A antibody

cAMP phosphodiesterase 11A antibody

cGMP phosphodiesterase 11A antibody

Cyclic nucleotide phosphodiesterase 11A antibody

Dual 3'' antibody

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody

FLJ23693 antibody

MGC133355 antibody

MGC133356 antibody

PDE 11A antibody

pde11 antibody

PDE11_HUMAN antibody

PDE11A antibody

PDE11A1 antibody

pde11a2 antibody

Phosphodiesterase 11A antibody

PPNAD2 antibody