General Information

Product

SMOX Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster

Immunogen

Synthetic peptide taken within amino acid region 434-484 on D. melanogaster SMOX protein.

Accession #

GenBank: AAC83344.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-0.95 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

Q9TZQ2

Overview

axon guidance;

dendrite morphogenesis;

determination of adult lifespan;

imaginal disc-derived wing morphogenesis ;

mushroom body development;

negative regulation of autophagy;

neuron development;

regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis;

regulation of mitotic cell cycle;

transcription, DNA-templated;

transforming growth factor beta receptor signaling pathway;

Molecular Function

Chromatin DNA binding; Sequence-specific DNA binding transcription factor activity

Structure

Belongs to the dwarfin/SMAD family.

Contains 1 MH1 (MAD homology 1) domain.

Contains 1 MH2 (MAD homology 2) domain.

Alternative Nomenclature

C20orf16 antibody

Flavin containing amine oxidase antibody

Flavin containing spermine oxidase antibody

PAO 1 antibody

Polyamine oxidase 1 antibody

Putative cyclin G1 interacting protein antibody

SMO antibody

Spermine oxidase antibod

General Information

Product

CXCR1 Antibody

Description

Affinity Purified IL-8 receptor type A Antibody C-epitope

Verified Applications

ELISA, ICC/IF, IHC-P, IP

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide, corresponding to a region within C terminal amino acids 272-350 of Human CXCR1.

Accession #

GenBank: BAA92293.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

5-.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500. Predicted molecular weight: 40 kDa.

Protein

Uniprot #

P25024

Overview

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Molecular Function

Chemotaxis

Subcellular Location

Cell membrane; Multi-pass membrane protein

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

C C antibody

C C CKR 1 antibody

C-X-C chemokine receptor type 1 antibody

CCCKR1 antibody

CD 181 antibody

CD128 antibody

CKR 1 antibody

CMKAR1 antibody

CXC-R1 antibody

High affinity interleukin-8 receptor A antibody

IL 8 receptor type 1 antibody

IL 8R A antibody

General Information

Product

CXCR1 Antibody

Description

Affinity Purified CXCR1 Antibody N-epitope

Verified Applications

ELISA, IHC-P, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide derived from the N terminus of Human CXCR1 protein.

Accession #

GenBank: AAY21523

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500. Predicted molecular weight: 40 kDa.

Protein

Uniprot #

P25024

Overview

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Molecular Function

Chemotaxis

Subcellular Location

Cell membrane; Multi-pass membrane protein

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

C C antibody

C C CKR 1 antibody

C-X-C chemokine receptor type 1 antibody

CCCKR1 antibody

CD 181 antibody

CD128 antibody

CKR 1 antibody

CMKAR1 antibody

CXC-R1 antibody

High affinity interleukin-8 receptor A antibody

IL 8 receptor type 1 antibody

IL 8R A antibody

General Information

Product

TPCN2 Antibody

Description

Affinity Purified Two pore calcium channel protein 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 205-255 on human TPC2 protein.

Accession #

NCBI:  NP_620714.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8NHX9

Overview

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.

Molecular Function

Calcium channel, Ion channel, Voltage-gated channel

Subcellular Location

Lysosome membrane; Multi-pass membrane protein

Expression

Widely expressed. Expressed at high level in liver and kidney.

Structure

Homodimer. Interacts with LRRK2.

Alternative Nomenclature

SHEP10 antibody

TPC2 antibody

Two pore calcium channel protein 2 antibody

Voltage dependent calcium channel protein TPC2 antibody

General Information

Product

TPCN2 Antibody

Description

Affinity Purified Two pore calcium channel protein 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 680-731.

Accession #

NCBI:  NP_666318.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8BWC0

Overview

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.

Molecular Function

Calcium channel, Ion channel, Voltage-gated channel

Subcellular Location

Lysosome membrane; Multi-pass membrane protein

Expression

Widely expressed. Expressed at high level in liver and kidney.

Structure

Homodimer. Interacts with LRRK2.

Alternative Nomenclature

SHEP10 antibody

TPC2 antibody

Two pore calcium channel protein 2 antibody

Voltage dependent calcium channel protein TPC2 antibody

General Information

Product

FAK1 Antibody

Description

Affinity Purified Focal Adhesion Kinase 1

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 740-790 on human focal adhesion kinase 1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q05397

Overview

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

Molecular Function

Developmental protein; Kinase; Transferase; Tyrosine-protein kinase

Subcellular Location

Cell junction › focal adhesion

Cell membrane; Peripheral membrane protein; Cytoplasmic side

Cytoplasm › cell cortex

Cytoplasm › cytoskeleton

Cytoplasm › cytoskeleton › microtubule organizing center › centrosome

Nucleus

Expression

Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.

Contains 1 FERM domain.

Contains 1 protein kinase domain.

Alternative Nomenclature

FADK 1 antibody

FADK antibody

FAK 1 antibody

FAK related non kinase polypeptide antibody

FAK1 antibody

Focal adhesion kinase 1 antibody

Focal adhesion kinase isoform FAK Del33 antibody

Focal adhesion kinase related nonkinase antibody

FRNK antibody

p125FAK antibody

pp125FAK antibody

PPP1R71 antibody

Protein phosphatase 1 regulatory subunit 71 antibody

Protein tyrosine kinase 2 antibody

Protein Tyrosine Kinase Cytoplasmic antibody

PTK 2 antibody

PTK2 protein tyrosine kinase 2 antibody

General Information

Product

SERINC4 Antibody

Description

Affinity Purified Serine incorporator 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 350-400 on human Serine incorporator 4 protein.

Accession #

NCBI: NP_001244960

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

A6NH21

Overview

Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Membrane; Multi-ass membrane protein

Structure

Belongs to the TDE1 family

Alternative Nomenclature

FLJ40363 antibody

SERC4_HUMAN antibody

SERINC4 antibody

Serine incorporator 4 antibody

General Information

Product

14-3-3 sigma Antibody

Description

Affinity Purified 14-3-3 protein sigma / STRATIFIN / SFN Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-220 on human 14-3-3 protein sigma / STRATIFIN / SFN protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P31947

Overview

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.1 Publication

p53-regulated inhibitor of G2/M progression.

Molecular Function

cadherin binding

identical protein binding

phosphoprotein binding

protein domain specific binding

protein kinase binding

protein kinase C inhibitor activity

Subcellular Location

Nucleus, secreted

Expression

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Structure

Belongs to the 14-3-3 family.

Alternative Nomenclature

14 3 3 protein sigma antibody

1433S_HUMAN antibody

Epithelial cell marker protein 1 antibody

Er antibody

HME 1 antibody

Mkrn3 antibody

Mme1 antibody

RP23 137L22.11 antibody

SFN antibody

SFN protein antibody

Stratifin antibody

YWHAS antibody

General Information

Product

Brk Antibody

Description

Affinity Purified Protein-Tyrosine Kinase 6 isoform Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-450 on mouse Protein-Tyrosine Kinase 6 isoform.

Accession #

NCBI:  NP_033210

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polylclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q64434

Molecular Function

ATP binding

identical protein binding

non-membrane spanning protein tyrosine kinase activity

protein tyrosine kinase activity

signaling receptor binding

Subcellular Location

Nucleus, Cytoplasm, Membrane, Ruffle

Expression

Expressed only in epithelial tissues, including the skin and lining of the alimentary canal. Restricted to the cell layers immediately above the proliferative cell zone in these epithelia.

Structure

The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity (By similarity).

Alternative Nomenclature

Breast tumor kinase antibody

Protein tyrosine kinase 6 antibody

Ptk6 antibody

Tyrosine-protein kinase BRK antibody

General Information

Product

DAP Kinase 1 Antibody

Description

Affinity Purified Death-associated protein kinase 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1370-1420 on human Death-associated protein kinase 1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P53355

Overview

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy.

Molecular Function

ATP binding

calmodulin binding

calmodulin-dependent protein kinase activity

GTP binding

identical protein binding

protein kinase activity

protein serine/threonine kinase activity

syntaxin-1 binding

Subcellular Location

Cytoskeleton

Expression

Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.

Structure

The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic and electrostatic contacts with the kinase core.

Alternative Nomenclature

DAK1 antibody

DAP K1 antibody

DAP kinase 1 antibody

DAPK antibody

DAPK1 antibody

Death Associated Protein Kinase 1 antibody