General Information

Product

WWOX 1/4 Antibody Affinity Purified

Description

Affinity Purified WW domain-containing Oxidoreductase isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on WWOX 1 and WWOX4 protein.

Accession #

NCBI:  NP_057457.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Western Blot

1:500

Protein

Uniprot #

Q9NZC7

Overview

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Molecular Function

Coenzyme binding; protein dimerization activity; cofactor binding;

Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus

Expression

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Structure

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.

Alternative Nomenclature

D16S432E antibody

FOR antibody

FOR II protein antibody

FRA16D antibody

fragile 16D oxido reductase antibody

fragile site FRA16D oxidoreductase antibody

HHCMA56 antibody

PRO0128 antibody

putative oxidoreductase antibody

WW domain-containing oxidoreductase antibody

WW domain-containing protein WWOX antibody

WWOX antibody

General Information

Product

WWOX2 Antibody Affinity Purified

Description

Affinity Purified Abberant WW domain-containing Oxidoreductase Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on WWOX2 protein.

Accession #

GenBank: AAL05451.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Western Blot

1:500

Protein

Uniprot #

Q9NZC7

Overview

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Molecular Function

Coenzyme binding; protein dimerization activity; cofactor binding;

Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus

Expression

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Structure

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.

Alternative Nomenclature

FOR antibody

FOR II protein antibody

FOR1 antibody

FRA16D antibody

Fragile 16D oxido reductase antibody

Fragile site FRA16D oxidoreductase antibody

Putative oxidoreductase antibody

WOX1 antibody

WW domain containing oxidoreductase antibody

WW domain containing protein WWOX antibody

WW domain oxidoreductase antibody

WWOX antibody

General Information

Product

WWOX3 Antibody

Description

Affinity Purified Oxidoreductase Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-300 on human WWOXdelta5-8 protein.

Accession #

GenBank: AAA21465.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9NZC7

Overview

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Molecular Function

Coenzyme binding; protein dimerization activity; cofactor binding;

Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus

Expression

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Structure

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207.

Alternative Nomenclature

D16S432E antibody

FOR antibody

FRA16D antibody

Fragile site FRA16D oxidoreductase antibody

HHCMA56 antibody

PRO0128 antibody

SCAR12 antibody

SDR41C1 antibody

short chain dehydrogenase/reductase family 41C member 1 antibody

WW domain-containing oxidoreductase antibody

wwox antibody

WWOX_HUMAN antibody

General Information

Product

KAP1 / TRIM28 Antibody Affinity Purified

Description

Affinity Purified Tripartite motif-containing 28 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 750-834 on mouse TRIM28 protein.

Accession #

GenBank: AAH89337

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q5EBP9

Molecular Function

Chromo shadow domain binding; Krueppel-associated box domain binding; Protein kinase activity

Subcellular Location

Chromatin; Nuclear heterochromatin; Nucleus; Nuclear euchromatin; Nucleoplasm

Structure

Contains RING-type zinc finger

Alternative Nomenclature

E3 SUMO protein ligase TRIM28 antibody

KAP 1 antibody

KRAB associated protein 1 antibody

KRIP1 antibody

Nuclear corepressor KAP 1 antibody

RING finger protein 96 antibody

RNF96 antibody

TF1B antibody

TIF1 beta antibody

Transcription intermediary factor 1 beta antibody

TRIM28 antibody

Tripartite motif containing 28 antibody

General Information

Product

DNA PKcs Antibody

Description

Affinity Purified DNA-dependent protein kinase catalytic subunit Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 4000-4128 of human DNPK1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P78527

Overview

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Nucleus

Expression

Found in axons of the central and peripheral nervous system;differentiated cell types of the intestine

Structure

Belongs to the immunoglobulin superfamily. DCC family;Contains 6 fibronectin type-III domains;Contains 4 Ig-like C2-type (immunoglobulin-like) domains

Alternative Nomenclature

DNA dependent protein kinase catalytic subunit antibody
DNA PK catalytic subunit antibody
DNA-PKcs antibody
DNAPK antibody
DNPK1 antibody
Hyper radiosensitivity of murine scid mutation, complementing 1 antibody
HYRC antibody
HYRC1 antibody
p350 antibody
p460 antibody
PKRDC antibody
Protein Kinase DNA Activated Catalytic Polypeptide antibody
XRCC7 antibody

General Information

Product

C9orf72 Antibody

Verified Applications

DB, ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-200 on human C9orf72 isoform a protein.

Accession #

NCBI:  NP_001242983.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q96LT7

Overview

May play a role in endosomal trafficking and autophagy

Molecular Function

Autophagy; endocytosis; cell death

Subcellular Location

Nucleus; Cytoplasm; Endosome; Lysosome; Autophagosome; Secreted

Expression

Both isoforms are widely expressed including kidney, lung, liver, heart, testis, cerebellum, frontal cortex and lymphoblasts.

Structure

Interacts with small Rab GTPases including RAB1A and RAB7A

Alternative Nomenclature

mALSFTD Antibody

chromosome 9 open reading frame 72 antibody

FTDals antibody

MGC23980 antibody

RP11-27J8.2 antibody

General Information

Product

Aquaporin 12 Antibody

Verified Applications

ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 240-290 on mouse Aquaporin 12 protein.

Accession #

GenBank:  EDL39975

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61-0.67 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q3V2I1

Overview

Water transport activity

Molecular Function

Transport

Subcellular Location

Membrane

Expression

Cytoplasm; plasma membrane; integral component of membrane

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

AQP 12 antibody

AQP 12A antibody

AQPX2 antibody

Aquaporin 12 antibody

Aquaporin 12A antibody

Aquaporin X2 antibody

General Information

Product

CXCR7 Antibody

Description

Affinity Purified Chemokine (C-X-C motif) receptor 7 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human CXCR7 protein.

Accession #

GenBank: AAH36661

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P25106

Overview

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival.

Molecular Function

Cell adhesion, Host-virus interaction

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Early endosome. Recycling endosome

Expression

Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue.

Structure

Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.

Alternative Nomenclature

ACKR3 antibody

atypical chemokine receptor 3 antibody

C X C chemokine receptor type 7 antibody

Chemokine orphan receptor 1 antibody

CMKOR1 antibody

CXC R7 antibody

G protein coupled receptor 159 antibody

G protein coupled receptor RDC1 homolog antibody

GPR159 antibody

GPRN1 antibody

RDC 1 antibody

General Information

Product

Prominin 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid regions 700-730 on CD133 protein

Accession #

NCBI:  XP_006714037.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

UPI0003EAF562

Overview

May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).

Molecular Function

Actinin binding; Cadherin binding

Subcellular Location

Apical cell membrane; Multi-pass membrane protein; microvillus membrane; cilium; photoreceptor outer segment; Endoplasmic reticulum-Golgi intermediate compartment

Expression

Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).

Structure

Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B.

Alternative Nomenclature

AC133 antibody

CD133 antibody

CORD12 antibody

Hematopoietic stem cell antigen antibody

MCDR2 antibody

MSTP061 antibody

RP41 antibody

STGD4 antibody

General Information

Product

Prominin 1 Antibody

Verified Applications

ELISA, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid regions 700-730 on CD133 protein

Accession #

NCBI:  XP_006714037.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

UPI0003EAF562

Overview

May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).

Molecular Function

Actinin binding; Cadherin binding

Subcellular Location

Apical cell membrane; Multi-pass membrane protein; microvillus membrane; cilium; photoreceptor outer segment.

Expression

Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).

Structure

Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B.

Alternative Nomenclature

AC133 antibody

CD133 antibody

CORD12 antibody

Hematopoietic stem cell antigen antibody

MCDR2 antibody

MSTP061 antibody

RP41 antibody

STGD4 antibody