General Information

Product

STING / TMEM173 Antibody

Description

Affinity Purified Stimulator of interferon genes protein isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acid region 332-342. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to a carrier protein using hetero bifunctional cross linker.

Sequence:

SFSLLSSQEVLRHLLRQEEKEEVT

Accession #

NCBI:  NP_938023

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

86WV6

Overview

Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm.

Molecular Function

cyclic-di-GMP binding, cyclic-GMP-AMP binding, identical protein binding

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Cytoplasm

Expression

Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.

Structure

Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2.

Alternative Nomenclature

endoplasmic reticulum IFN stimulator antibody

ERIS antibody

FLJ38577 antibody

Mediator of IRF3 activation antibody

MITA antibody

Mitochondrial mediator of IRF3 activation antibody

MPYS antibody

N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody

NET23 antibody

Stimulator of interferon genes antibody

STING antibody

Tmem173 antibody

Transmembrane protein 173 antibody

General Information

Product

DRIP130 Antibody

Description

Affinity Purified MED23 protein Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic pepetide taken within amino acid region 650-700 on MED23 protein.

Accession #

GenBank: AAH60759.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9ULK4

Overview

Required for transcriptional activation subsequent to assembly of preinitiation complex. Component of mediator complex, mediator functions as a bridge to convey information from gene specific regulatory proteins to basal RNA polymerase II transcription machinery.

Molecular Function

Transcription coactivator activity

Subcellular Location

Nucleus

Alternative Nomenclature

130 kDa transcriptional co activator antibody

ARC 130 antibody

Cofactor required for Sp1 transcriptional activation subunit 3 130kDa antibody

CRSP 130 antibody

CRSP 133 antibody

DRIP 130 antibody

KIAA1216 antibody

MED 23 antibody

SUR 2 antibody

Vitamin D3 receptor interacting protein antibody

General Information

Product

CAB13 Antibody

Description

Affinity Purified Chlorophyll a-b binding protein 13 Antibody

Verified Applications

DB, ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Plant

Immunogen

Synthetic peptide taken within amino acid region 100-200 on Solanum lycopersicum Chlorophyll a-b binding protein 13.

Physical Properties

Quantity

100 µg

Volume

200 µl

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Preservative: 0.02% Sodium azide
Constituents: 30% Glycerol, 69% Tris glycine

pH 7.4-7.8.Contains .5% stabilizing proteins.

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P27489

Overview

Light receptor captures and delivers excitation energy to photosystems.

Molecular Function

Chlorophyll; Chromophore; Magnesium; Metal-binding

Subcellular Location

Chloroplast; Membrane; Photosystem I & II, Plastid; Thylakoid

Structure

N-terminus of the protein extends into the stroma where it is invovled with adhesion of granal membranes and post-translational modifications.

Alternative Nomenclature

Recombinant Solanum lycopersicum

Chloroplast (CAB13) Antibody

LHCII type III CAB-13 Antibody

General Information

Product

PGCG Antibody

Description

Affinity Purified Guanylyl Cyclase G Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase G protein.

Accession #

GenBank: AF024622.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P55205

Overview

Binds to a yet not identified ligand.

Possible role in processes such as water and electrolyte balance, and muscle contraction.

Molecular Function

Lyase, Receptor

Subcellular Location

Isoform 1:  Cell membrane; Single-pass type I membrane protein.  Isoform 2:  Cytoplasm

Expression

Expressed in lung, kidney and skeletal muscle. Low levels in intestine.

Structure

Homodimer or heterodimer with NPR1.

Alternative Nomenclature

CYGF antibody

GC F antibody

guanylate cyclase 2D-like, membrane (retina-specific) antibody

Guanylate cyclase 2F antibody

GUC2DL antibody

GUC2F antibody

Gucy2f antibody

RETGC-2 antibody

retinal antibody

Rod outer segment membrane guanylate cyclase 2 antibody

ROS-GC2 antibody

General Information

Product

CHERP Antibody

Description

Affinity Purified SR-related CTD associated factor 6 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Predicted: Horse, Guinea pig, Cow, Cat, Dog, Zebrafish

Immunogen

Synthetic peptide corresponding to a region within internal seuence amino acids 846-913 of human CHERP.

Sequence:

EQGIQDPIKG GDVRDKWDQY  KGVGVALDDP YENYRRNKSY SFIARMKARD

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500. Predicted Molecular weight: 104 kDa

Protein

Uniprot #

Q8IWX8

Overview

Involved in calcium homeostasis growth and proliferation

Molecular Function

RNA processing; cellular calcium ion homeostasis

Subcellular Location

Cytoplasm; Endoplasmic Reticulum

Expression

Brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle and in cultured HEL and Dami cells.

Structure

Contains 1 CID domain, 1 G-patch domain and 1 SURP motif repeat

Alternative Nomenclature

Calcium homeostasis endoplasmic reticulum protein antibody

DAN16 antibody

DAN26 antibody

Protein with polyglutamine repeat antibody

SCAF6 antibody

SR related CTD associated factor 6 antibody

SRA1 antibody

General Information

Product

Cytohesin 4 Antibody Affinity Purified

Description

Affinity Purified Cytohesin 4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-362 on human Cytohesin 4 protein.

Accession #

GenBank: AAH41161.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9UIA0

Overview

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Molecular Function

ARF guanyl-nucleotide exchange factor activity, lipid binding

Subcellular Location

Cell membrane; Peripheral membrane protein

Expression

Expressed predominantly in peripheral blood leukocytes.

Structure

Contains 1 PH domain, Contains 1 SEC7 domain

Alternative Nomenclature

AI467541 antibody

CYT4 antibody

Cyth4 antibody

Cytohesin 4 antibody

DJ63G5.1 antibody

FLJ00017 antibody

PH antibody

PH, SEC7 and coiled coil domain containing protein 4 antibody

Pleckstrin homology, SEC7, AND coiled coil domains protein 4 antibody

Pscd4 antibody

RGD1564842 antibody

SEC7 and coiled-coil domain-containing protein 4 antibody

General Information

Product

MTAP Antibody

Description

Affinity Purified Methylthioadenosine Phosphorylase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 233-283 on human methylthioadenosine phosphorylase protein.

Accession #

GenBank: AAG38871.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q13126

Overview

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Molecular Function

Phosphorylase activity; S-methyl-5-thioadenosine phosphorlase activity;  Glycosyl transferase; Purine Salvage

Subcellular Location

Cytoplasm; Nucleus

Expression

Ubiquitously expressed.

Structure

Homotrimer

Alternative Nomenclature

5' methylthioadenosine phosphorylase antibody

BDMF antibody

c86fus antibody

DMSFH antibody

DMSMFH antibody

Epididymis luminal protein 249 antibody

HEL 249 antibody

LGMBF antibody

MeSAdo phosphorylase antibody

Methylthioadenosine phosphorylase antibody

MSAP antibody

MTA phosphorylase antibody

MTAP antibody

MTAPase antibody

S methyl 5 thioadenosine phosphorylase antibody

General Information

Product

inaD Antibody

Description

Affinity Purified inactivation no afterpotential D, isoform A Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Fruity Fly (Drosophila melanogaster)

Immunogen

Synthetic peptide corresponding to C terminal amino acids 659-674 of Fruit fly (Drosophila melanogaster) inaD protein.

Sequence:

EVTRPKPTLRTEAPKA

Accession #

NCBI:  NP_726260.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q24008

Overview

Involved in the negative feedback regulation of the light-activated signaling cascade in photoreceptors through a calcium-mediated process.

Molecular Function

Calmodulin binding, myosin III binding, receptor signaling complex scaffold activity, structural molecule activity, myosin binding, photoreceptor activity

Subcellular Location

Cell membrane, preipheral membran protein

Expression

Expressed in rhabdomeres of the compound eyes and ocelli.

Alternative Nomenclature

Inactivation-no-after-potential D protein antibody

inaD antibody

General Information

Product

PDEB1 Antibody Affinity Purified

Description

Affinity Purified Trypanosoma brucei class 1 phosphodiesterase PDEB1 (PDEB1) Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Trypanosoma brucei

Immunogen

Synthetic MAP peptide taken within amino acid region 1-50 on Trypanososoma brucei class 1 phosphodiesterase PDEB1 protein.

Accession #

GenBank: AY028446.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q8WQX9

Overview

Hydrolase, 3',5'-cyclic-nucleotide phosphodiesterase activity

Alternative Nomenclature

Phosphodiesterase 2 C PDEB1 PDE1B Phosphodiesterase B1

General Information

Product

Affinity Purified TPCN1 Antibody

Description

Two pore calcium channel protein 1 isoform 2 Antibody Affinity Purified

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within TMD7 and TMD8 on human TPC1 protein.

Accession #

NCBI:  NP_060371.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9ULQ1

Overview

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal and endosomal membrane.

Molecular Function

Calcium channel, Ion channel, Voltage-gated channel

Subcellular Location

Lysosome membrane; Multi-pass membrane protein, Endosome membrane; Multi-pass membrane protein

Expression

Highest expression found in the heart and kidney, and lowest expression found in the spleen.

Structure

Dimer.

Alternative Nomenclature

TPC1 antibody

TPCN 1 antibody

Two pore calcium channel protein 1 antibody

Two pore channel 1 antibody

Two pore segment channel 1 antibody

Voltage dependent calcium channel protein TPC1 antibody