General Information

Product

ADCY9 Antibody Affinity Purified

Description

Affinity Purified Adenylate cyclase type 9 Antibody

Verified Applications

ELISA, WB; predicted to work with:  CM, ICC, IHC, IF

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60503

Overview

Plays role in interplay between intracellular calcium and cAMP.  Docking site for calcineurin.

Molecular Function

Adenylate cyclase activity; metal ion binding; ATP binding

Subcellular Location

Axon; dendrite; integral component of plasma membrane

Expression

Expressed in lung cells, airway smooth muscle

Structure

Adenylyl cyclase class-4/guanylyl cyclase family.  Contains 2 guanylate cyclase domains.

Alternative Nomenclature

ATP pyrophosphate lyase 9 antibody

KIAA0520 antibody

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

General Information

Product

ARHGEF7 Antibody

Description

Affinity Purified Rho-guanine nucleotide exchange factor 7 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q14155

Overview

Acts as RAC1 guanine nucleotide exchange factor and can induce membrane ruffling.

Molecular Function

Neurogenesis

Subcellular Location

Cell junction; foacl adhesion; Cell projection ruffle; Cell cortex

Structure

Interacts with PAK kinases through SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1.

Alternative Nomenclature

ARHG7 antibody

Beta pix antibody

COOL1 antibody

Nbla10314 antibody

P50 antibody

p85 antibody

P85SPR antibody

PAK interacting exchange factor beta antibody

PAK3 antibody

SH3 domain containing proline rich protein antibody

General Information

Product

CCR5 Antibody

Description

Affinity Purified Chemokine receptor type 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human CCR5 protein.

Accession #

NCBI: AAB65720.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P51681

Overview

Receptor for several inflammatory C-C chemokines.  May play a role in control of granulocytic lineage proliferation or differentiation.

Molecular Function

actin binding; C-C chemokin binding; GPCR; Receptor; Transducer; Host-virus interaction

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

Spleen, Thymus, myeloid cell line THP-1, promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells.  Lesser expressed in peripheral blood leukocytes, small intestine and ovary and lung.

Structure

Interacts with PRAF2, HIV-1 surface protein gp120. Glycosylation on Ser-6 is required for binding with CCL4.

Alternative Nomenclature

AM4 7 antibody

CCCKR 5 antibody

CD 195 antibody

CHEMR13 antibody

HIV 1 Fusion Coreceptor antibody

IDDM22 antibody

MIP-1 alpha receptor antibody

General Information

Product

CCR3 Antibody

Description

Affinity Purified C-C chemokine receptor type 3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human CCR3 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P51677

Overview

Receptor for C-C type chemokine.  Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta.

Molecular Function

C-C receptor activity; Host-virus interaction; Receptor; Transducer

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

eosinophils and trace amounts in neutrophils and monocytes

Structure

Binds to HIV-1 Tat.

Alternative Nomenclature

B Chemokine Receptor antibody

CC CKR 3 antibody

CD 193 antibody

CMKBR 3 antibody

CMKBR1L2 antibody

Eosinophil CC Chemokine Receptor 3 antibody

Eosinophil Eotaxin Receptor antibody

Macrophage inflammatory protein 1 alpha receptor like 2 antibody

MIP1 Alpha RL2 antibody

General Information

Product

CCR2 Antibody

Description

Affinity Purified C-C chemokine receptor type 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 20-70 on human CCR2 protein.

Accession #

NCBI: NP_955783

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P41597

Overview

Receptor for CCL2, CCL7 and CCL13 chemokines.  Transduces a signal by increasing intracellular calcium ion levels.  Alternative coreceptor with CD4 for HIV-1 infection.

Molecular Function

Host-virus interaction; GPCR; Transducer

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

Induced; Up-regulated by CREB3

Structure

Binds to HIV-1 Tat.  Interacts with ARRB1

Alternative Nomenclature

CC CKR 2 antibody

CD192 antibody

CKR2A antibody

CKR2B antibody

CMKBR2 antibody

MCP1 RECEPTOR antibody

Monocyte chemoattractant protein 1 receptor antibody

General Information

Product

CCR7 Antibody

Description

Affinity Purified C-C chemokine receptor type 7 Antibody

Verified Applications

CM, DB, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on CCR7 protein.

Accession #

NCBI: NP_955783

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Western Blot

1:500

Protein

Uniprot #

Q6U2D6

Molecular Function

G-protein coupled receptor

Subcellular Location

Membrane

Structure

Belongs to G-protein coupled receptor 1 family; Transmembrane helix

Alternative Nomenclature

BLR 2 antibody

C C chemokine receptor type 7 antibody

C C CKR 7 antibody

CCR 7 antibody

CD 197 antibody

CDW197 antibody

CMKBR7 antibody

EBI 1 antibody

EBV Induced G Protein Coupled Receptor 1 antibody

Epstein Barr virus induced G protein coupled receptor antibody

EVI 1 antibody

Lymphocyte Specific G Protein Coupled Peptide Receptor antibody

MGC108519 antibody

MIP3 Beta Receptor antibody

General Information

Product

Cannabinoid Receptor II Antibody

Description

Affinity Purified Cannabinoid receptor 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-350 on mouse CB2 Receptor protein common to both CB2L and CB2S.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P47936

Overview

Heterotrimeric GPCR for endocannabinoid 2-arachidonoylglycerol mediating inhibition of Adenylate cyclase.  Functions in inflammatory response, nociceptive transmission and bone homeostasis.

Molecular Function

Inflammatory response; GPCR; Receptor; Transducer

Subcellular Location

Cell membrane; Multi-pass membrane protein; Dendrite; Perikaryon

Expression

Cells of hematopoietic origin.  Expressed in skin in suprabasal layers and hair follices.  In brain by neurons and glial cells.  Expressed in osteoblasts, osteocytes and osteoclasts.

Structure

belongs to G-protein coupled receptor 1 family

Alternative Nomenclature

Cannabinoid receptor 2 macrophage antibody

CB 2 antibody

CNR2 antibody

CX 5 antibody

testis-dominant CNR2 isoform CB2 antibody

General Information

Product

Calcium Sensing Receptor Antibody

Description

Affinity Purified extracellular calcium-sensing receptor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Predicted: Rabbit, Horse, Chicken, Cow, Dog, Chimpanzee, Macaque Monkey

Immunogen

Synthetic peptide corresponding to amino acids 47-69 on human CASR gene.

Sequence:

KDQDLKSRPESVECIRYNFRGFR

Accession #

NCBI: NP_000379.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500. Predicted molecular weight: 121 kDa

Protein

Uniprot #

P41180

Overview

Senses change in extracellular concentration of calcium channels.

Molecular Function

GPCR, Receptor, Transducer.

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

Temporal lobe, frontal lobe, parietal lobe, hippocampus, cerebellum, kidney, lung, liver, heart, skeletal muscle and placenta.

Structure

Interacts with VCP, RNF19A and ARRB1.

Alternative Nomenclature

CAR antibody

EIG8 antibody

FHH antibody

FIH antibody

GPRC2A antibody

HHC1 antibody

Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody

NSHPT antibody

Parathyroid Cell calcium-sensing receptor antibody

PCAR1 antibody

General Information

Product

N-Chimaerin Antibody

Description

Affinity Purified N-Chimaerin isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on alpha 2 Chimaerin protein.

Accession #

NCBI:  NP_001813

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P15882

Overview

GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.

Molecular Function

GTPase activation

Subcellular Location

Cytosol

Expression

In neurons in brain regions that are involved in learning and memory processes.

Structure

Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.

Alternative Nomenclature

A-chimaerin antibody

Alpha-chimerin antibody

ARHGAP2 antibody

CHN antibody

Chn1 antibody

N chimaerin antibody

NC antibody

Rho GTPase-activating protein 2 antibody

RHOGAP2 antibody

General Information

Product

Chimaerin beta 2 Antibody

Description

Affinity Purified Beta-chimaerin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-180 on beta 2-chimaerin protein.

Accession #

NCBI: NM_004067

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P52757

Overview

GTPase-activating protein for p21-rac.  May play role in progression from low-grade to high-grade tumors.

Molecular Function

Metal binding; Zinc

Subcellular Location

Membrane

Expression

Brain, pancreas, heart, placenta.  Weakly expressed in kidney and liver.

Structure

Contains 1 phorbol-ester/DAG-type zinc finger; 1 Rho-GAP domain; 1 SH2 domain.

Alternative Nomenclature

ARHGAP3 antibody

BCH antibody

CHN2 antibody

MGC138360 antibody

Rho GTPase activating protein 3 antibody

RHOGAP3 antibody