General Information

Product

EDG8 Antibody

Description

Affinity Purified Sphingosine 1-phosphate receptor 5 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 380-400 of rat S1P5R/EDG8 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9JKM5

Overview

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of

Alternative Nomenclature

EDG 8 antibody

Endothelial differentiation G protein coupled receptor 8 antibody

Endothelial differentiation sphingolipid G protein coupled receptor 8 antibody

S1P receptor 5 antibody

S1P receptor Edg 8 antibody

Sphingosine 1 Phosphate Receptor 5 antibody

Sphingosine 1-phosphate receptor Edg-8 antibody

SPPR2 antibody

General Information

Product

SRPX2 Antibody

Description

Affinity Purified Sushi repeat-containing protein SRPX2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 430-470 on human SRPX2 protein.

Accession #

NCBI:  NP_055282.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60687

Overview

Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays role in andiogenesis by inducing endothelial cell migration and formation of vascular network Involved in cell migration and adhesion.

Molecular Function

Hepatocyte growth factor binding, identical protein binding, receptor binding

Subcellular Location

Secreted, cytoplasm, cell surface, cell junction, synapse

Expression

Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa.

Alternative Nomenclature

BPP antibody

CBPS antibody

PMGX antibody

RESDX antibody

SRPUL antibody

SRPX2 antibody

Sushi repeat containing protein SRPX2 antibody

Sushi repeat containing protein X linked 2 antibody

Sushi repeat protein antibody

General Information

Product

ULK1 Antibody

Description

Affinity Purified Serine/Threonine-protein kinase ULK1 Antibody

Verified Applications

ELISA, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Panda

Immunogen

Synthetic peptide taken within amino acid region 1000-1050 on mouse ULK1 protein.

Accession #

NCBI:  NP_003556.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

O75385

Overview

Involved in autophagy in response to starvation. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

Molecular Function

ATP Binding, protein serine/threonine kinase activity, Rab GTPase binding, protein complex binding

Subcellular Location

Cytoplasm, cytosol, preautphagosomal structure. (Note: under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome)

Expression

Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Alternative Nomenclature

ATG1 autophagy related 1 homolog antibody

ATG1A antibody

Autophagy related protein 1 homolog antibody

hATG1 antibody

Serine/threonine-protein kinase ULK1 antibody

ULK1 antibody

Unc 51 like kinase 1 antibody

Unc-51 like kinase 1 (C. elegans) antibody

UNC51 antibody

General Information

Product

Survivin Antibody Affinity Purified

Description

Affinity Purified Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.

Accession #

NCBI:  NP_001012270.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-1.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O15392

Overview

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Molecular Function

Protease inhibitor, Repressor, Thiol protease inhibitor

Subcellular Location

Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody

Expression

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Structure

Monomer or Homodimer.

Alternative Nomenclature

API4 antibody

Apoptosis Inhibitor 4 antibody

Apoptosis inhibitor survivin antibody

Baculoviral IAP repeat-containing protein 5 antibody

BIRC 5 antibody

EPR 1 antibody

IAP4 antibody

Survivin variant 3 alpha antibody

SVV antibody

TIAP antibody

General Information

Product

IBP160 Antibody

Description

Affinity Purified Aquarius Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1250-1300 on human RNA helicase aquarius protein.

Accession #

NCBI:  NP_055506

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60306

Overview

Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP biogenesis

Molecular Function

RNA-binding

Subcellular Location

Nucleus, Spliceosome

Structure

Spliceosome C complex. Component of XAB2 complex.

Alternative Nomenclature

AQR antibody

fSAP164 antibody

functional spliceosome-associated protein 164 antibody

Intron-binding protein of 160 kDa antibody

General Information

Product

BTBD3 Antibody

Description

Affinity Purified BTBD/ POZ domain containing protein 3 isoform A Antibody

Verified Applications

ELISA, IHC, IPP, WB

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 410-460 on human BTBD3 protein.

Accession #

NCBI: NP_055777

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y2F9

Overview

Acts as a key regulator of dendritic field orientation during development of sensory cortex. Directs dendrites toward active axon terminals.

Molecular Function

Neurogenesis

Subcellular Location

Cytoplasm; Nucleus

Structure

Contains BACK domain and BTB domain

Alternative Nomenclature

BTB/POZ domain-containing protein 3 antibody

dJ742J24.1 antibody

General Information

Product

Capricious Antibody Affinity Purified

Description

Affinity Purified Capricious, isoform A Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

D. melanogaster

Immunogen

Synthetic peptide corresponding to 400-450 on Capricious isoform A protein.

Accession #

NCBI:AAF49837

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q9VU53

Overview

Invovled in axon guidance, branch fusion, opening tracheal system, synapse assembly and others.

Subcellular Location

Muscle cell projection

Structure

Contains Leucine-rich repeat

Alternative Nomenclature

BcDNA:LD07388 antibody

caps antibody

CG11282 antibody

CT31495 antibody

Dmel\CG11282 antibody

l(3)02937 antibody

l(3)rM632 antibody

General Information

Product

CCR4 Antibody

Description

Affinity Purified C-C chemokine receptor type 4 Antibody

Verified Applications

CF, DB, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 4 protein.

Accession #

NCBI: NP_005499

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P51679

Overview

Receptor for C-C type chemokines CCL17/TARC and CCL22/MDC.  Functions as chemoattractant homing receptor on circulating memory lymphocytes and as coreceptor for some primary HIV-2 isolates.  Can also mediate hippocampal-neuron survival.

Molecular Function

GPCR, Receptor, Transducer.

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Thymus, peripheral blood leukocytes including T-cells, CD4+ cells, basophils and in platelets.  Expressed less in spleen and in monocytes.  Also found in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expresseding cutaneous lymphocyte antigen.  Expressed in brain and microvascular and coronary artery endothelial cells.

Structure

Belongs to G-protein coupled receptor 1 family.  Interacts with CREB3.

Alternative Nomenclature

CD194 antibody

ChemR13 antibody

CKR4 antibody

CMKBR 4 antibody

HGCN 14099 antibody

K5 5 antibody

General Information

Product

SHISA9 Antibody

Description

Affinity Purified Cytosine-knot AMPA receptor modulating protein 44a Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse

Immunogen

Synthetic peptide taken within amino acid region 250-300 on CKAMP44a protein.

Accession #

NCBI: ADD64956.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9CZN4

Overview

Regulates short term neuronal synaptic plasticity in dentate gyrus.  Also associates with AMPA receptosr in synaptic spines, promotes AMPA receptor desensitization at excitatory synapses.

Molecular Function

Regulation of short-term neuronal synaptic plasticity

Subcellular Location

Cell projection; Single-pass type I membrane protein; Cell junction; Synapse

Expression

Brain specific, expressed mostly in neurons and most brain structures during embryonic and postnatal development.

Structure

Component of some AMPA receptors complex, and atleast composed of some AMPA receloptr, CACNG2, SHISA9 and also  a low level of DLG4

Alternative Nomenclature

CKAMP44 antibody

shisa family member 9 antibody

General Information

Product

SHISA9 isoform X2 Antibody

Description

Affinity Purified Protein SHISA-9 isoform X2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse

Immunogen

Synthetic peptide taken within amino acid region 300-400 on rat CKAMP44A/B protein.

Accession #

NCBI:  XP_006220625.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI0003D0C173

Overview

Regulates short term neuronal synaptic plasticity in dentate gyrus.  Also associates with AMPA receptosr in synaptic spines, promotes AMPA receptor desensitization at excitatory synapses.

Molecular Function

Regulation of short-term neuronal synaptic plasticity

Subcellular Location

Cell projection; Single-pass type I membrane protein; Cell junction; Synapse

Expression

Brain specific, expressed mostly in neurons and most brain structures during embryonic and postnatal development.

Structure

Component of some AMPA receptors complex, and atleast composed of some AMPA receloptr, CACNG2, SHISA9 and also  a low level of DLG7

Alternative Nomenclature

2700045P11Rik antibody

CKAMP44 antibody

Cystine knot AMPAR modulating protein antibody

FLJ10015 antibody

FLJ37653 antibody

FLJ58277 antibody

FLJ99079 antibody

FLJ99234 antibody

Protein shisa-9 antibody

shisa family member 9 antibody

Shisa homolog 9 (Xenopus laevis) antibody

shisa9 antibody