General Information

Product

LIMK1 Antibody

Description

Affinity Purified LIM domain kinase 1 isoform 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 550-647 on human LIM Kinase 1 protein.

Accession #

NCBI:  NP_002305.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P53667

Overview

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways.

Molecular Function

ATP binding, protein kinase activity, protein serine/threonine kinase activity, zinc ion binding, heat shock protein binding

Subcellular Location

Cytoplasm, nucleus

Expression

Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Alternative Nomenclature

LIM domain kinase 1 antibody

LIM motif-containing protein kinase antibody

LIMK antibody

LIMK-1 antibody

General Information

Product

Lysozyme Antibody

Description

Affinity Purified Homo sapiens lysozyme gene Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Partially purified full-length lysozyme protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P61626

Overview

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Molecular Function

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Subcellular Location

Secreted

Structure

Monomer

Alternative Nomenclature

4 beta N acetylmuarmidase C antibody

1 antibody

4-beta-N-acetylmuramidase C antibody

EC 3.2.1.17 antibody

LYSC_HUMAN antibody

Lysosyme antibody

Lysozyme (renal amyloidosis) antibody

Lysozyme C antibody

LYZ antibody

LZM antibody

Renal amyloidosis antibody

General Information

Product

MSX1 Antibody 

Description

Affinity Purified MSX1 protein Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide:

DEEGAKPKVSPSLLPFSVE

corresponding to amino acids 46-64 of Mouse Msx1 protein. The peptide was post synthetically modified and conjugated to KLH using hetero bifunctional cross linker for immunization of rabbits. 

Accession #

GenBank: AAH67353.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

P28360

Overview

Acts as a transcriptional repressor;play a role in limb-pattern formation,cranofacial development and odontogenesis

Molecular Function

Developmental protein, Repressor

Subcellular Location

Nucleus

Expression

Expressed in the developing nail bed mesenchyme.

Structure

Belongs to the Msh homeobox family

Alternative Nomenclature

AA675338 antibody

AI324650 antibody

Homeobox protein Hox-7 antibody

Homeobox protein MSX 1 antibody

HOX 7 antibody

HYD 1 antibody

msh (Drosophila) homeo box homolog 1

Msh antibody

MSX 1 antibody

OFC5 antibody

STHAG1 antibody

General Information

Product

MUC1 Antibody

Description

Affinity Purified Mucin 1, transmembrane Antibody

Verified Applications

ELISA, IHC, IP

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on MUCIN1 protein.

Accession #

NCBI:  NM_182741.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P15941

Overview

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.

Molecular Function

transcription cofactor activity

Subcellular Location

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

Expression

Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only.

Alternative Nomenclature

ADMCKD antibody

Breast carcinoma-associated antigen DF3 antibody

CA 15 3 antibody

CD227 antigen antibody

DF3 antigen antibody

EMA antibody

Episialin antibody

Epithelial basement membrane antigen antibody

H23 antigen antibody

KL 6 antibody

MAM 6 antibody

MCD antibody

MCKD1 antibody

MUC 1 antibody

Peanut-reactive urinary mucin antibody

Polymorphic epithelial mucin antibody

Tumor associated epithelial membrane antigen antibody

General Information

Product

POMT2 Antibody

Description

Affinity Purified Protein O-mannosyl-transferase 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-560 on human POMT2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunohistochemistry

1:1000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9UKY4

Overview

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.

Molecular Function

dolichyl-phosphate-mannose-protein mannosyltransferase acitivity, metal ion binding

Subcellular Location

Endoplasmic reticulum membrane, multi-pass membrane protein

Expression

Highly expressed in testis; detected at low levels in most tissues.

Alternative Nomenclature

A830009D15Rik antibody

AW046274 antibody

DKFZp686G10254 antibody

Dolichyl phosphate mannose protein mannosyltransferase 2 antibody

FLJ22309 antibody

LGMD2N antibody

MDDGA2 antibody

MDDGB2 antibody

MDDGC2 antibody

POMT 2 antibody

Protein O mannosyltransferase 2 antibody

Putative protein O mannosyltransferase antibody

rCG_20643 antibody

General Information

Product

Phospho Survivin Antibody Affinity Purified

Description

Affinity Purified Phosphorylated Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Phosphorylated synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.

Accession #

NCBI:  NP_001012270.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-1.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O15392

Overview

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Molecular Function

Protease inhibitor, Repressor, Thiol protease inhibitor

Subcellular Location

Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody

Expression

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Structure

Monomer or Homodimer.

Alternative Nomenclature

API4 antibody

Apoptosis Inhibitor 4 antibody

Apoptosis inhibitor survivin antibody

Baculoviral IAP repeat-containing protein 5 antibody

BIRC5 antibody

EPR 1 antibody

IAP4 antibody

Survivin variant 3 alpha antibody

SVV antibody

TIAP antibody

General Information

Product

RASD2 Antibody

Description

Affinity Purified Ras homolog enriched in striatum Antibody

Verified Applications

ELISA, IHC ,IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-317 on RASD2 protein.

Accession #

GenBank: AAH36988.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:500

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8JZW1

Molecular Function

GTP binding

Alternative Nomenclature

GTP binding protein Rhes antibody

MGC:4834 antibody

Ras homolog enriched in striatum antibody

RASD 2 antibody

Rhes antibody

TEM2 antibody

Tumor endothelial marker 2 antibody

General Information

Product

RPE65 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on mouse RPE65 protein.

Accession #

GenBank: AAL01119.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q91ZQ5

Overview

Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester.

Molecular Function

Hydrolase, Isomerase

Subcellular Location

Cytoplasm, Cell membrane; Lipid anchor, Microsome membrane

Expression

Retinal pigment epithelium  specific

Structure

Interacts with MYO7A; this mediates light-dependent intracellular transport of RPE65.

Alternative Nomenclature

All-trans-retinyl-palmitate hydrolase antibody

LCA 2 antibody

Leber congenital amaurosis antibody

p63 antibody

rd 12 antibody

Retinal pigment epithelium specific 61 kDa protein antibody

Retinal pigment epithelium specific 65 kDa protein antibody

retinitis pigmentosa 20 antibody

Retinoid isomerohydrolase antibody

RP20 antibody

General Information

Product

ARTS Antibody Affinity Purified

Description

Affinity Purified Septin-4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-450 on SEPT4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-075 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43236

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.

Molecular Function

GTPase activity, structural molecule activity, GTP binding

Subcellular Location

Cytoplasm, cytoskeleton. (Note: In platelets, found in areas surrounding alpha-granules)

Expression

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in plate

Alternative Nomenclature

Apoptosis Related Protein TGFb Signalling antibody

ARTS antibody

Bradeion beta antibody

Brain protein H5 antibody

CE5B3 antibody

CE5B3 beta antibody

cell division control-related protein 2 antibody

cerebral protein 7 antibody

H5 antibody

hCDCREL-2 antibody

Hucep 7 antibody

MART antibody

Peanut-like protein 2 antibody

PNUTL2 antibody

SEP4 antibody

SEPT4 antibody

Septin-4 antibody

General Information

Product

SIGLEC10 Antibody

Description

Affinity Purified Sialic acid-binding Ig-like lectin 10 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 650-697 on human SIGLEC10 protein.

Accession #

NCBI:  NP_149121.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.56-0.60 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q96LC7

Overview

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Molecular Function

carbohydrate binding

Subcellular Location

Isoform 1,2,3,4: cell membrane, single-pass type I membrane protein; isoform 5: secreted

Expression

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Alternative Nomenclature

PRO940 antibody

sialic acid binding Ig like lectin 10 Ig like lectin 7 antibody

Sialic acid binding Immunoglobulin like lectin 10 antibody

SIGLEC 10 antibody

Siglec G antibody

Siglec-like protein 2 antibody

SIGLEC10 antibody

Siglecg antibody

SLG2 antibody