General Information

Product

SIDT1 Antibody Affinity Purified

Description

Affinity Purified SIDT1 protein Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Rat, Mouse

Immunogen

Synthetic peptide taken within amino acid region 390-430 on human SIDT1 protein.

Accession #

Gen Bank: AAI17223.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NXL6

Molecular Function

RNA transmembrane transporter activity

Subcellular Location

membrane, multi-pass membrane protein

Alternative Nomenclature

Msid2 antibody

SID1 antibody

SID1 transmembrane family, member 1 antibody

General Information

Product

SIRT3 Antibody

Description

Affinity Purified NAD-dependent protein deacetylase sirtuin-3, mitochondrial Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide:

RDLVGPFVLSPRRKDVVQL

corresponding to amino acids 203-221 of rat SIRT3 protein.

Accession #

NCBI:  NP_001099783

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

B2RZ31

Molecular Function

enzyme binding, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K14 specific)

Alternative Nomenclature

Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase antibody

NAD dependent deacetylase sirtuin 3 mitochondrial antibody

Regulatory protein SIR2 homolog 3 antibody

Silent mating type information regulation 2 S.cerevisiae homolog 3 antibody

SIR 2 like protein 3 antibody

SIR 3 antibody

SIR2 L3 antibody

Sirtuin 3 antibody

Sirtuin type 3 antibody

General Information

Product

SIRT7 Antibody

Description

Affinity Purified Sirtuin (silent mating type information regulation 2 homolog) 7 Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-400 on mouse SIRT7 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8BKJ9

Overview

NAD-dependent protein deacetylase that specifially mediates deacetylation of histone H3 at 'Lys-18'. Displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression.

Molecular Function

Chromatin binding, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), metal ion binding

Subcellular Location

Cytoplasm, nucleus, nucleolus. (Note: Located close to the nuclear membrane when in cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Expression

Detected in liver, spleen and testis. Detected in embryos.

Structure

Belongs to the Sirtuin Family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain.

Alternative Nomenclature

NAD dependent deacetylase sirtuin 7 antibody

Regulatory protein SIR2 homolog 7 antibody

Silent mating type information regulation 2 homolog antibody

SIR2 L7 antibody

SIR2 like protein 7 antibody

Sir2 related protein type 7 antibody

SIRT7 antibody

Sirtuin 7 antibody

Sirtuin type 7 antibody

General Information

Product

LARP7 Antibody Affinity Purified

Description

Affinity Purified LARP7 protein Antibody C-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 360-410 on human LARP7 protein.

Accession #

GenBank:   AAI07710.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q4G0J3

Overview

Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

Molecular Function

RNA-binding; RNA processing

Subcellular Location

Nucleus

Structure

Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.

Alternative Nomenclature

HDCMA18P antibody

La related protein 7 antibody

La ribonucleoprotein domain family member 7 antibody

P TEFb interaction protein for 7SK stability antibody

PIP7S antibody

General Information

Product

LARP7 Antibody Affinity Purified

Description

Affinity Purified LARP7 protein Antibody N-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 300-350 on human LARP7 protein.

Accession #

GenBank:   AAI07710.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q4G0J3

Overview

Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

Molecular Function

RNA-binding; RNA processing

Subcellular Location

Nucleus

Structure

Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.

Alternative Nomenclature

HDCMA18P antibody

La related protein 7 antibody

La ribonucleoprotein domain family member 7 antibody

P TEFb interaction protein for 7SK stability antibody

PIP7S antibody

General Information

Product

C6orf150 Antibody

Description

Affinity Purified Cyclic GMP-AMP synthase Antibody N-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid regions 350-450 on human cGAS protein.

Accession #

NCBI:  NP_612450

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8N884

Overview

Catalyzes the formation of cyclic GMP-AMP from ATP and GTP.  Has antiviral activity through acting as a cystolic DNA senser.

Molecular Function

Nucleotidyltransferase; ATP binding; DNA binding

Subcellular Location

Cytoplasm; Cytosol

Expression

Is expressed in the monocytic cell line THP1 by type 1 Interferons

Structure

Monomer when in absence of DNA.  Homodimer when bound to DNA.

Alternative Nomenclature

C6orf150 antibody

cGAMP synthase antibody

cGAS antibody

Chromosome 6 open reading frame 150 antibody

Cyclic GMP-AMP synthase antibody

h-cGAS antibody

Hypothetical protein LOC115004 antibody

Mab 21 domain containing 1 antibody

MB21D1 antibody

protein MB21D1 antibody

Uncharacterized protein C6orf150 antibody

General Information

Product

C6orf150 Antibody

Description

Affinity Purified Cyclic GMP-AMP synthase Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid regions 400-450 on human cGAS protein.

Accession #

NCBI:  NP_612450

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8N884

Overview

Catalyzes the formation of cyclic GMP-AMP from ATP and GTP.  Has antiviral activity through acting as a cystolic DNA senser.

Molecular Function

Nucleotidyltransferase; ATP binding; DNA binding

Subcellular Location

Cytoplasm; Cytosol

Expression

Is expressed in the monocytic cell line THP1 by type 1 Interferons

Structure

Monomer when in absence of DNA.  Homodimer when bound to DNA.

Alternative Nomenclature

C6orf150 antibody

cGAMP synthase antibody

cGAS antibody

Chromosome 6 open reading frame 150 antibody

Cyclic GMP-AMP synthase antibody

h-cGAS antibody

Hypothetical protein LOC115004 antibody

Mab 21 domain containing 1 antibody

MB21D1 antibody

protein MB21D1 antibody

Uncharacterized protein C6orf150 antibody

General Information

Product

Myocilin Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on Myocilin protein.

Accession #

GenBank: BAA24532.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q99972

Overview

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.

Molecular Function

fibronectin binding, myosin light chain binding, frizzled binding

Subcellular Location

Secreted, Golgi apparatus, Cytoplasmic vessicle

Expression

Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.

Structure

Homodimer (via N-terminus). Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling. Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBb3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and aggregation.

Alternative Nomenclature

Glaucoma 1 open angle antibody

GLC1A antibody

GPOA antibody

JOAG antibody

Mutated trabecular meshwork-induced glucocorticoid response protein antibody

MYOC antibody

Myocilin antibody

TIGR antibody

General Information

Product

Myocilin Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on Myocilin protein.

Accession #

GenBank: BAA24532.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q99972

Overview

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.

Molecular Function

fibronectin binding, myosin light chain binding, frizzled binding

Subcellular Location

Secreted, Golgi apparatus, Cytoplasmic vessicle

Expression

Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.

Structure

Homodimer (via N-terminus). Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling. Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBb3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and aggregation.

Alternative Nomenclature

Glaucoma 1 open angle antibody

GLC1A antibody

GPOA antibody

JOAG antibody

Mutated trabecular meshwork-induced glucocorticoid response protein antibody

MYOC antibody

Myocilin antibody

TIGR antibody

General Information

Product

Myocilin Antibody

Verified Applications

ELISA, ICC/IF, IHC, IP, Immunomicroscopy, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to N terminal amino acids 25-46 of Myocilin. Peptide was covalently modified and conjugated to KLH.

Sequence:

CLWDVGARTAQLRKANDQSGR

Accession #

GenBank: BAA24532.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500. Predicted molecular weight: 55 kDa.

Protein

Uniprot #

Q99972

Overview

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.

Molecular Function

fibronectin binding, myosin light chain binding, frizzled binding

Subcellular Location

Secreted, Golgi apparatus, Cytoplasmic vessicle

Expression

Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.

Structure

Homodimer (via N-terminus). Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling. Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBb3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and aggregation.

Alternative Nomenclature

Glaucoma 1 open angle antibody

GLC1A antibody

GPOA antibody

JOAG antibody

Mutated trabecular meshwork-induced glucocorticoid response protein antibody

MYOC antibody

Myocilin antibody

TIGR antibody