General Information

Product

DISC1 Antibody

Description

Affinity Purified Disrupted in Schizophrenia 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 730-750 on DISC1 protein.

Accession #

GenBank:  CAI17205

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.76 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q5T409

Overview

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus.

Molecular Function

Neurogenesis, Wnt signaling pathway

Subcellular Location

Membrane, Microtubule, Postsynaptic cell membrane, Synapse

Expression

Ubiquitous.

Alternative Nomenclature

C1orf136 antibody

KIAA0457 antibody

RP4-730B13.1 antibody

SCZD9 antibody

General Information

Product

HAND2 Antibody

Description

Affinity Purified heart- and neural crest derivatives-expressed protein 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-100 on Human HAND2 protein.

Accession #

NCBI: NP_073187

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.5-.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P61295

Overview

Essential for cardiac morphogenesis, particularly for he formation of the right ventricle and of the aortic arch arteries.

Molecular Function

DNA-Binding

Subcellular Location

Nucleus

Structure

Contains 1 basic helix-loop-helix domain

Alternative Nomenclature

AI225906 antibody

AI661148 antibody

autonomic nervous system and neural crest derivatives-expressed protein 2 antibody

Basic helix loop helix transcription factor HAND2 antibody

bHLHa26 antibody

Class A basic helix-loop-helix protein 26 antibody

Deciduum antibody

DHAND 2 antibody

Ehand 2 antibody

FLJ16260 antibody

heart antibody

Hed antibody

Highly similar to dHAND M musculus antibody

MGC125303 antibody

MGC125304 antibody

Th 2 antibody

Thing2 antibody

General Information

Product

MeCP2 isoform 2 Antibody

Description

Affinity Purified Methyl-CpG-binding protein 2 isoform 2 Antibody

Verified Applications

ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 436-486 on Methyl-CpG-binding protein 2 isoform 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P51608

Overview

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) .

Molecular Function

Chromatin binding, DNA binding, mRNA binding, double-stranded methylated DNA binding, poly(A) RNA binding, siRNA binding

Subcellular Location

Nucleus (Note: Colocalized with methyl-CpG in the genome)

Expression

Present in all adult somatic tissues tested.

Alternative Nomenclature

AUTSX 3 antibody

Mbd5 antibody

MeCP2 antibody

Methyl CpG binding protein 2 (Rett syndrome) antibody

MRX 16 antibody

MRX 79 antibody

MRXS 13 antibody

MRXSL antibody

PPMX antibody

RS antibody

RTS antibody

RTT antibody

WBP10 antibody

General Information

Product

MeCP2 isoform 1 Antibody

Description

Affinity Purified Methyl-CpG-binding protein 2 isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on mouse methyl-CpG-binding protein 2 isoform 1.

Accession #

NCBI:  NP_004983

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P51608

Overview

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

Molecular Function

Chromatin binding, DNA binding, mRNA binding, double-stranded methylated DNA binding, poly(A) RNA binding, siRNA binding

Subcellular Location

Nucleus (Note: Colocalized with methyl-CpG in the genome)

Structure

Interacts with FNBP3. Interacts with CDKL5 (PubMed:15917271). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2.

Expression

Present in all adult somatic tissues tested.

Alternative Nomenclature

AUTSX 3 antibody

Mbd5 antibody

MeCP-2 protein antibody

MeCP2 antibody

Methyl CpG binding protein 2 (Rett syndrome) antibody

Methyl CpG binding protein 2 antibody

MRX 16 antibody

MRX 79 antibody

MRXS13 antibody

MRXSL antibody

PPMX antibody

RS antibody

RTS antibody

RTT antibody

WBP 10 antibody

General Information

Product

Nogo Antibody

Description

Affinity Purified Reticulon-4 isoform A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1100-1200 on Nogo AS protein.

Accession #

NCBI:  NP_065393.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NQC3

Overview

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching.  Regulates neurite fasciculation, branching and extension in the developing nervous system.

Molecular Function

poly(A) RNA binding

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression

Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle.   Isoform 2 is widely expressed except for the liver.  Isoform 3 is expressed in brain, skeletal muscle and adipocytes.  Isoform 4 is testis-specific.

Structure

Binds to RTN4R, interacts with Bcl-xl and Bcl-2.  Isoform 2 binds to NGBR and RTN3.  Isoform 2 and Isoform 3 interact with BACE1 and BACE2, interacts with RTN4IP1 and ATL1.

Alternative Nomenclature

1110020G17Rik antibody

AA407876 antibody

AA409940 antibody

AA960376 antibody

ASY antibody

C130026I10Rik antibody

Foocen antibody

Glut4 vesicle 20 kDa protein antibody

Human NogoA antibody

Kiaa0886 antibody

KIAA4153 antibody

MGC116054 antibody

MGC139261 antibody

mKIAA0886 antibody

mKIAA4153 antibody

My043 protein antibody

Nbla00271 antibody

Nbla10545 antibody

Neurite growth inhibitor 220 antibody

Neuroendocrine-specific protein antibody

NI-250 antibody

Nogo A antibody

NOGO antibody

Nogo B antibody

Nogo C antibody

NSP antibody

NSP CL antibody

rat N antibody

Reticulon 4 antibody

Reticulon 5 antibody

RTN X antibody

RTN4 A antibody

RTN4-B1 antibody

Vp20 antibody

General Information

Product

Phospho Survivin Antibody Affinity Purified

Description

Affinity Purified Phosphorylated Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Phosphorylated synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.

Accession #

NCBI:  NP_001012270.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-1.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O15392

Overview

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Molecular Function

Protease inhibitor, Repressor, Thiol protease inhibitor

Subcellular Location

Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody

Expression

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Structure

Monomer or Homodimer.

Alternative Nomenclature

API4 antibody

Apoptosis Inhibitor 4 antibody

Apoptosis inhibitor survivin antibody

Baculoviral IAP repeat-containing protein 5 antibody

BIRC5 antibody

EPR 1 antibody

IAP4 antibody

Survivin variant 3 alpha antibody

SVV antibody

TIAP antibody

General Information

Product

Robo3 Antibody Affinity Purified

Description

Affinity Purified Homer protein homolog 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human RIG1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Z214

Overview

ostsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.

Molecular Function

G-protein coupled glutamate receptor binding, identical protein binding, receptor binding

Subcellular Location

Cytoplasm, Cell junction

Expression

Highly expressed in cortex, Purkinje cells of the cerebellum, hippocampus, striatum and olfactory bulb. Isoform 1and isoform 3 are expressed in skeletal and cardiac muscle.

Structure

Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Alternative Nomenclature

HGPPS antibody

HGPS antibody

RB inhibiting gene 1 antibody

Rbig1 antibody

Retinoblastoma inhibiting gene 1 antibody

Rig1 antibody

Roundabout axon guidance receptor homolog 3 antibody

Roundabout like protein 3 antibody

General Information

Product

TMPRSS2 Antibody Affinity Purified

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 470-530 on human TMPRSS2 protein.

Accession #

GenBank: BAB70683.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q920K3

Molecular Function

scavenger receptor activity, serine-type endopeptidase activity

Alternative Nomenclature

D16Ertd61e antibody

Epitheliasin antibody

PP9284 antibody

PRSS10 antibody

Serine protease 10 antibody

TMPRSS2 ERG FUSION GENE, INCLUDED antibody

TMPRSS2 ETV1 FUSION GENE, INCLUDED antibody

Transmembrane protease serine 2 catalytic chain antibody

Transmembrane protease, serine 2, EC 3.4.219 antibody

General Information

Product

Survivin Antibody Affinity Purified

Description

Affinity Purified Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.

Accession #

NCBI:  NP_001012270.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-1.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O15392

Overview

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Molecular Function

Protease inhibitor, Repressor, Thiol protease inhibitor

Subcellular Location

Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody

Expression

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Structure

Monomer or Homodimer.

Alternative Nomenclature

API4 antibody

Apoptosis Inhibitor 4 antibody

Apoptosis inhibitor survivin antibody

Baculoviral IAP repeat-containing protein 5 antibody

BIRC 5 antibody

EPR 1 antibody

IAP4 antibody

Survivin variant 3 alpha antibody

SVV antibody

TIAP antibody

General Information

Product

C9orf72 Antibody

Verified Applications

DB, ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-200 on human C9orf72 isoform a protein.

Accession #

NCBI:  NP_001242983.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q96LT7

Overview

May play a role in endosomal trafficking and autophagy

Molecular Function

Autophagy; endocytosis; cell death

Subcellular Location

Nucleus; Cytoplasm; Endosome; Lysosome; Autophagosome; Secreted

Expression

Both isoforms are widely expressed including kidney, lung, liver, heart, testis, cerebellum, frontal cortex and lymphoblasts.

Structure

Interacts with small Rab GTPases including RAB1A and RAB7A

Alternative Nomenclature

mALSFTD Antibody

chromosome 9 open reading frame 72 antibody

FTDals antibody

MGC23980 antibody

RP11-27J8.2 antibody