General Information

Product

Glucose Transporter 8 Antibody Affinity Purified

Description

Affinity Purified Solute carrier family 2, facilitated glucose transporter member 8 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse , Rat

Immunogen

Synthetic peptide taken within amino acid region 400-500 on GLUT8 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.56-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NY64

Overview

Insulin-regulated facilitative glucose transporter.  Binds cytochalasin B in glucose-inhibitable manner.

Molecular Function

Sugar Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein; Cytoplasmic vessicle membrane

Expression

Highly expressed in testis; lower amounts in other tissues.  Down regulated by estrogen.

Structure

Interacts with AP2B1

Alternative Nomenclature

Glucose transporter type 8 antibody

Glucose transporter type X1 antibody

GLUT8 antibody

GLUTX1 antibody

solute carrier family 2 (facilitated glucose transporter) member 8 antibody

General Information

Product

Glucose Transporter 9 Antibody Affinity Purified

Description

Affinity Purified Solute carrier family 2, facilitated glucose transporter member 9 Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 50-570 on Glut 9 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,500

ELISA

1:4,500

Immunoprecipitation

1:200

Western Blot

1:500-1:750

Protein

Uniprot #

Q9NRM0

Overview

Urate and fructose transport.  Also transports glucose at lower rate.

Molecular Function

Sugar Transport

Subcellular Location

Membrane; Multi-pass membrane

Expression

Basolateral membranes of proximal renal tubular cells, liver and placenta.  Also found in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articiular cartilage.

Structure

Transmembrane helix

Alternative Nomenclature

glucose transporter 9 antibody

GLUT9 antibody

GLUTX antibody

Human glucose transporter like protein 9 antibody

SLC2A9 antibody

Solute carrier family 2, facilitated glucose transporter member 9 antibody

UAQTL2 antibody

Urate voltage driven efflux transporter 1 antibody

URATv1 antibody

General Information

Product

GAPDH Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 75-150 on mouse Glyceraldehyde-3-phosphate dehydrogenase protein.

Accession #

NCBI:  NP_032110.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P16858

Overview

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively.

Molecular Function

Oxidoreductase, Transferase

Subcellular Location

Cytoplasm, Cytoskeleton, Nucleus

Expression

brain; cerebullum; heart; kidney; liver; skeletal muscle

Structure

Homotetramer

Alternative Nomenclature

AI747587 antibody

cytoplasmic antibody

EC 1.1.1.8 antibody

FLJ26652 antibody

G3PD antibody

Gdc1 antibody

Gdp1 antibody

Glycerol 3 phosphate dehydrogenase 1 antibody

Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic antibody

GPDH antibody

GPDH-C antibody

HTGTI antibody

MGC93453 antibody

MGPD antibody

mKIAA4010 antibody

General Information

Product

Isocitrate dehydrogenase Antibody

Description

Affinity Purified IDH1 Antibody

Verified Applications

CM, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-414 on human Isocitrate dehydrogenase.

Accession #

GenBank: CAG38738.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6FI37

Overview

Catalytic activity: Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.  Binds 1 magnesium or manganese ion per subunit as cofactor.

Molecular Function

Magnesium; Manganese; Metal-binding; NADP

Subcellular Location

Cytoplasm; Peroxisome

Structure

Belongs to icocitrate and isopropylmalate dehydorgenases family

Alternative Nomenclature

Cytosolic NADP isocitrate dehydrogenase antibody

Epididymis luminal protein 216 antibody

Epididymis secretory protein Li 26 antibody

HEL-216 antibody

ICDH antibody

IDCD antibody

IDH antibody

Idh1 antibody

IDP antibody

IDPC antibody

Isocitrate dehydrogenase [NADP] cytoplasmic antibody

NADP dependent isocitrate dehydrogenase cytosolic antibody

NADP(+)-specific ICDH antibody

Oxalosuccinate decarboxylase antibody

PICD antibody

General Information

Product

Parkin Antibody Affinity Purified

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 390-440 on human Parkin protein.

Accession #

GenBank: BAA25751.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60260

Overview

Acts within a multiprotein E3 ubiquitin ligase complex, by catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.  It also participates in the removal and/or detoxification of proteins that are abnormally folded or damaged.

Molecular Function

Ligase, Chaperone binding, Protein kinase binding

Subcellular Location

Cytoplasm, Nucleus, Endoplasmic reticulum, Mitochondrion

Expression

Expressed highly in the brain, and is also expressed in the heart, testis and skeletal muscle.  Expression is down-regulated or absent in tumor biopsies and in the brain of PARK2 patients.

Structure

Forms E3 ubiquitin ligase complex with UBE2L3 or UBE2L6.  Binds to C2A and C2B domains of SYTqq and interacts and regulates the turnovers of SEPT5.

Alternative Nomenclature

AR JP antibody

E3 ubiquitin ligase antibody

FRA6E antibody

LPRS 2 antibody

PARK 2 antibody

Parkin 2 antibody

Parkinson disease (autosomal recessive juvenile) 2 antibody

Parkinson protein 2, E3 ubiquitin protein ligase (parkin) antibody

PDJ antibody

PRKN 2 antibody

Ubiquitin E3 ligase PRKN antibody

General Information

Product

Phospho TORC2 Antibody

Description

Affinity Purified Phosphorylated CREB-regulated transcription coactivator 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Phosphorylated synthetic peptide corresponding to unique amino acid sequence on TORC2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q53ET0

Overview

Activator, cAMP response element binding protein binding

Subcellular Location

Cytoplasm, Nucleus

Expression

Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle.

Alternative Nomenclature

CREB regulated transcription coactivator 2 antibody

CRTC2 antibody

TORC-2 antibody

Transducer of CREB protein 2 antibody

Transducer of regulated cAMP response element-binding protein antibody

General Information

Product

SIRT7 Antibody

Description

Affinity Purified Sirtuin (silent mating type information regulation 2 homolog) 7 Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 340-390 on human SIRT7 protein.

Accession #

GenBank: AAH17305.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9NRC8

Overview

NAD-dependent protein deacetylase that specifially mediates deacetylation of histone H3 at 'Lys-18'. Displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression.

Molecular Function

Chromatin binding, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), metal ion binding

Subcellular Location

Cytoplasm, nucleus, nucleolus. (Note: Located close to the nuclear membrane when in cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Expression

Detected in liver, spleen and testis. Detected in embryos.

Structure

Belongs to the Sirtuin Family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain.

Alternative Nomenclature

NAD dependent deacetylase sirtuin 7 antibody

Regulatory protein SIR2 homolog 7 antibody

Silent mating type information regulation 2 homolog antibody

SIR2 L7 antibody

SIR2 like protein 7 antibody

Sir2 related protein type 7 antibody

SIRT7 antibody

Sirtuin 7 antibody

Sirtuin type 7 antibody

General Information

Product

SIRT5 Antibody

Description

Affinity Purified Sirtuin 5 (silent mating type information regulation 2 homolog) 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 260-310 on rat Sirtuin 5 protein.

Accession #

NCBI: NP_001004256.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.66-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q68FX9

Overview

NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.

Molecular Function

Hydrolase; Metal-binding; NAD; Zinc

Subcellular Location

Isoform 1:  Cytoplasm, Mitochondrion  Isoform 2:  Mitochondrion

Expression

Widely expressed.

Structure

Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding.

Alternative Nomenclature

NAD dependent deacetylase sirtuin 5 antibody

Regulatory protein SIR2 homolog 5 antibody

Silent mating type information regulation 2 Sir2 like 5 antibody

SIR2-like protein 5 antibody

SIR2L5 antibody

Sirtuin type 5 antibody

General Information

Product

EAAT2 Antibody

Description

Affinity Purified Excitatory amino acid transporter 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C terminal amino acids 550-574 of Human EAAT2. 

Sequence:

KVTLAANGKSADCSVEEEPWKREK

Accession #

NCBI:  NP_004162.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43004

Overview

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Molecular Function

Glutamate:sodium symporter activity, L-glutamate transmembrane transporter activity, sodium:dicarboxylate symporter activity

Subcellular Location

Membrane, multi-pass membrane protein

Alternative Nomenclature

Excitatory amino acid transporter 2 antibody

Excitotoxic amino acid transporter 2 antibody

Glial high affinity glutamate transporter antibody

GLT1 antibody

Glutamate aspartate transporter II antibody

Glutamate transporter 1 antibody

Glutamate/aspartate transporter II antibody

SLC1A2 antibody

Sodium dependent glutamate aspartate transporter 2 antibody

Solute carrier family 1 member 2 antibody

General Information

Product

SREBP1 Antibody Affinity Purified

Description

Affinity Purified Sterol regulatory element-binding protein 1 Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 950-1000 on human Sterol regulatory element binding transcription factor 1 protein.

Accession #

GenBank: AAH63281.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P36956

Overview

Transcriptional activator required for lipid homeostasis.

Molecular Function

Activator

Subcellular Location

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Expression

liver, adrenal gland, lung, ovary, hepatoma cell lines, kidney, brain, white fat, and muscle.

Structure

Belongs to the SREBP family

Alternative Nomenclature

ADD 1 antibody

Class D basic helix-loop-helix protein 1 antibody

Processed sterol regulatory element-binding protein 1 antibody

SREBF 1 antibody

SREBP1 antibody

Sterol regulatory element-binding transcription factor 1 antibody