General Information

Product

BMP1 Antibody

Description

Affinity Purified Bone morphogenetic protein 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 680-730 on human BMP1 protein.

Accession #

NCBI:  NP_001190

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.56 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500

Protein

Uniprot #

P13497

Overview

Cleaves the C-terminal propeptides of procollagen I, II and II. Induces bone and cartilage formation.

Molecular Function

Chondrogenesis; Differentiation; Osteogenesis; Calcium, Zinc, Metal binding

Subcellular Location

trans-Golgie network; secreted; ECM

Expression

Ubiquitous

Structure

Belongs to peptidase M12A family. Contains 5 CUB domains and 2 EGF-like domains.

Alternative Nomenclature

Mammalian tolloid protein antibody

mTld antibody

OI13 antibody

PCOLC antibody

PCP2 antibody

Procollagen C endopeptidase antibody

TLD antibody

Tolloid, Drosophila, homolog of antibody

General Information

Product

Bestrophin 4 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, D. melanogaster

Immunogen

Synthetic peptide taken within amino acid region 400-500 on human Bestrophin 4 protein.

Accession #

NCBI:  NP_695006.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8NFU0

Overview

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Molecular Function

Chloride Channel

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta.

Structure

Belongs to bestrophin Family

Alternative Nomenclature

BEST 4 antibody

MGC126872 antibody

Vitelliform macular dystrophy 2 like 2 antibody

VMD2-like gene 2 antibody

VMD2L2 antibody

General Information

Product

Bestrophin 3 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey

Immunogen

Accession #

NCBI: NP_116124.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8N1M1

Overview

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Molecular Function

Ion transport; Calcium, Chloride.

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Expression

Skeletal muscle and weakly in brain, spinal cord, bone marrow and retina.

Structure

Belongs to bestrophin Family

Alternative Nomenclature

BEST 3 antibody

Bestrophin3 antibody

MGC13168 antibody

MGC40411 antibody

Vitelliform macular dystrophy 2-like protein 3 antibody

VMD2L3 antibody

General Information

Product

Adiponectin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Pig

Immunogen

Synthetic peptide taken within amino acid region 150-243 on pig Adiponectin protein.

Accession #

GenBank: AY589691

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.65 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q69907

Overview

Involved in brown fat cell differentiation, responses to drugs, detection of oxidative stress glucose homeostasis and fatty acid oxidation.  Invovled in regulation of DNA biosynthetic processes.

Molecular Function

Hormone activity; receptor binding

Subcellular Location

Cell periphery; collagen trimer; extracellular space; cell surface; endoplasmic reticulum; perinuclear region of cytoplasm

Expression

Secreted

Alternative Nomenclature

30 kDa adipocyte complement related protein antibody

ACDC antibody

ACRP 30 antibody

Adipocyte antibody

Adipocyte C1q and collagen domain containing protein antibody

Adipocyte complement related 30 kDa protein antibody

adipocyte-specific secretory protein antibody

Adiponectin antibody

adiponectin, C1Q and collagen domain containing antibody

AdipoQ antibody

Adipose most abundant gene transcript 1 antibody

Adipose specific collagen like factor antibody

ADIPQTL1 antibody

ADPN antibody

APM 1 antibody

C1q and collagen domain-containing protein antibody

GBP 28 antibody

Gelatin binding protein antibody

Gelatin binding protein 28 antibody

General Information

Product

STING / TMEM173 Antibody

Description

Affinity Purified Stimulator of interferon genes protein isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acid region 332-342. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to a carrier protein using hetero bifunctional cross linker.

Sequence:

SFSLLSSQEVLRHLLRQEEKEEVT

Accession #

NCBI:  NP_938023

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

86WV6

Overview

Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm.

Molecular Function

cyclic-di-GMP binding, cyclic-GMP-AMP binding, identical protein binding

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Cytoplasm

Expression

Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.

Structure

Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2.

Alternative Nomenclature

endoplasmic reticulum IFN stimulator antibody

ERIS antibody

FLJ38577 antibody

Mediator of IRF3 activation antibody

MITA antibody

Mitochondrial mediator of IRF3 activation antibody

MPYS antibody

N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody

NET23 antibody

Stimulator of interferon genes antibody

STING antibody

Tmem173 antibody

Transmembrane protein 173 antibody

General Information

Product

alpha Actinin 4 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 140-190 on human alpha Actinin 4 protein.

Accession #

NCBI:  NP_004915

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43707

Overview

F-actin cross-linking protein that anchors variety of intracellular structures.  Bundling protein involved in vesicular trafficking via its association with the CART complex.

Structure

Widely Expressed

Alternative Nomenclature

F actin cross linking protein antibody

Focal segmental glomerulosclerosis 1 antibody

FSGS 1 antibody

Non-muscle alpha-actinin 4 antibody

General Information

Product

Adenylate Cyclase 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rabbit, Rat

Immunogen

Synthetic peptide corresponding to conserved sequence at or near C terminal end of protein that is unique to rat/mouse Adenylyl Cyclase 1 protein.

Accession #

GenBank: AAC29478 

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55- 0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500. Detects a band 127-10 kDa

Protein

Uniprot #

O88444

Overview

This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina

Molecular Function

ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane protein. Cytoplasm

Expression

Expressed throughout inner ear development. Brain, retina and adrenal medulla.

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains

Alternative Nomenclature

3'5' cyclic AMP synthetase antibody

ADCY1 antibody

adenyl cyclase antibody

Adenylate cyclase 1 antibody

ATP pyrophosphate lyase antibody

Brain adenylate cyclase 1 antibody

Ca(2+)/calmodulin activated adenylyl cyclase antibody

EC 4.6.1.1 antibody

General Information

Product

ADCY3 Antibody

Description

Particulate Adenylate cyclase type 3 Antibody Affinity Purified

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Dog, Human, Mouse, Rat

Immunogen

Synthetic peptide generated against a sequence unique to PAC3 protein. All peptides were amidated before conjugation.

Accession #

NCBI:  NP_004027

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Polyclonal

Clonality

Rabbit

Determinant

Affinity Purified

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60266

Overview

Mediates odorant detection via modulation of intracellular cAMP concentration

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane protein

Expression

Brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle

Structure

Belongs to adenylyl cyclase class-4 and guanylyl cyclase family.  Contains 2 guanylate cyclase domains.

Alternative Nomenclature

ATP pyrophosphate-lyase 3 antibody

olfactive type antibody

General Information

Product

Adenylate Cyclase 4 Antibody

Description

Affinity Purified Adenylate cyclase type 4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on rat Particulate Adenylyl Cyclase 4 protein.

Accession #

NCBI:  NP_062158

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.526 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100-1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100-1:200

Immunofluorescence

1:100-1:200

Immunohistochemistry

1:100-1:200

Western Blot

1:500

Protein

Uniprot #

Q66HK5

Molecular Function

Nucleotide-binding

Subcellular Location

Membrane

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family

Alternative Nomenclature

AC4 antibody

Adcy4 antibody

Adenylate cyclase 4 antibody

ATP pyrophosphate-lyase 4 antibody

General Information

Product

ADCY6 Antibody

Description

Affinity Purified Adenylate cyclase type 6 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH.

Sequence:

DERKTAWGERNGQKR

Accession #

GenBank: AAD29856.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100-1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100-1:200

Immunofluorescence

1:100-1:200

Immunohistochemistry

1:100-1:200

Western Blot

1:500

Protein

Uniprot #

Q03343

Overview

Membrane bound calcium-inhibitable adenylyl cyclase.

Molecular Function

Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding

Subcellular Location

Membrane; Multi-pass membrane protein; Cell projection; cilium

Structure

Part of a complex containing AKAP5, ADCY5, PDE4C, PKD2. Interacts with RAF1.

Alternative Nomenclature

AC6 

ACVI 

ADCYB 

Adenylate cyclase 6 

ATP pyrophosphate-lyase 6 

Ca(2+) inhibitable adenylyl cyclase 

EC 4.6.1.1 

KIAA0422