General Information

Product

FGR Antibody

Description

Affinity Purified Tyrosine-protein kinase, Gardner-Rasheed feline sarcoma viral oncogene homolog Antibody

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-529 on human Fgr protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P09769

Molecular Function

Kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane; Lipid anchor, Cytoplasmic side

Expression

Found in neutrophils, monocytes and natural killer cells at protein level.  Found in monocytes and large lymphocytes

Structure

Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A or FCGR2B.  Interacts with SYK, FLT3, HCLS1, SIRPA, PTPNS1, CBL, PIK3R1 and FASLG.

Alternative Nomenclature

c fgr protooncogene antibody

c src 2 proto oncogene antibody

FLJ43153 antibody

Gardner Rasheed feline sarcoma viral (v fgr) antibody

MGC75096 antibody

p55 c fgr protein antibody

Proto oncogene c Fgr antibody

SRC 2 antibody

Tyrosine-protein kinase Fgr antibody

General Information

Product

GIRK3 Antibody Affinity Purified

Description

Affinity Purified G protein-activated inward rectifier potassium channel 3 Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid region on human GIRK3 protein.

Accession #

NCBI:  NP_004974.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q92806

Molecular Function

Potassium

Subcellular Location

Membrane; Multi-pass membrane protein

Structure

Belongs to inward rectifier-type potassium channel family

Alternative Nomenclature

G protein activated inward rectifier potassium channel 3 antibody

GIRK3 antibody

Inward rectifier K(+) channel Kir3.3 antibody

inwardly rectifying subfamily J member 9 antibody

Kcnj9 antibody

KIR3.3 antibody

Potassium channel antibody

Potassium channel inwardly rectifying subfamily J member 9 antibody

General Information

Product

GRIK1 Antibody Affinity Purified

Description

Affinity Purified Glutamate receptor GLUR5 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid region on GluR5.

Accession #

NCBI: NP_666184

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8BRT2

Overview

Extracellular-glutamate-gated ion channel activity

Molecular Function

Ion transport

Subcellular Location

Cell junction, Cell membrane, Synapse

Structure

Transmembrane helix

Alternative Nomenclature

Glutamate receptor metabotropic 5 antibody

GPRC1E antibody

GRM5 antibody

Metabotropic glutamate receptor 5 variant F antibody

Metabotropic glutamate receptor 5 variant G antibody

Metabotropic glutamate receptor 5 variant H antibody

mGlu5 antibody

mGluR5a antibody

mGluR5b antibody

General Information

Product

Glucose transporter GLUT4 Antibody

Description

Affinity Purified Solute carrier family 2 , facilitated glucose transporter member 4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 450-509 on mouse Solute carrier family 2, facilitated glucose transporter member 4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DOT Blot

1:4,000

ELISA

1:4,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:1,000

Protein

Uniprot #

P14142

Overview

Insulin-regulated facilitative glucose transporter

Molecular Function

glucose transmembrane transporter activity;insulin-responsive hydrogen:glucose symporter activity

Subcellular Location

Cell membrane, Cytoplasm, Membrane

Expression

Skeletal and cardiac muscles; brown and white fat.

Structure

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily

Alternative Nomenclature

insulin-responsive antibody

Glucose transporter GLUT 4 antibody

GLUT 4 antibody

kug antibody

SLC 2A4 antibody

Solute carrier family 2, facilitated glucose transporter member 4 antibody

General Information

Product

Glucose Transporter 8 Antibody Affinity Purified

Description

Affinity Purified Solute carrier family 2, facilitated glucose transporter member 8 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse , Rat

Immunogen

Synthetic peptide taken within amino acid region 400-500 on GLUT8 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.56-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NY64

Overview

Insulin-regulated facilitative glucose transporter.  Binds cytochalasin B in glucose-inhibitable manner.

Molecular Function

Sugar Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein; Cytoplasmic vessicle membrane

Expression

Highly expressed in testis; lower amounts in other tissues.  Down regulated by estrogen.

Structure

Interacts with AP2B1

Alternative Nomenclature

Glucose transporter type 8 antibody

Glucose transporter type X1 antibody

GLUT8 antibody

GLUTX1 antibody

solute carrier family 2 (facilitated glucose transporter) member 8 antibody

General Information

Product

IL17RB Antibody

Description

Affinity Purified Interleukin-17 receptor B precursor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-400 on IL17RB protein.

Accession #

NCBI:  NP_061195.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NRM6

Overview

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Molecular Function

Cytokine receptor activity

Subcellular Location

Isoform 1: membrane, single-pass type I membrane protein; Isoform 2: secreted

Expression

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

Alternative Nomenclature

CRL 4 antibody

Cytokine receptor CRL4 antibody

EVI 27 antibody

IL 17 receptor B antibody

IL 17 receptor homolog 1 antibody

IL 17B receptor antibody

IL 17Rh1 antibody

MGC5245 antibody

General Information

Product

IL32 Antibody

Description

Affinity Purified Interleukin-32 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 180-234 on human Interleukin-32 (natural killer cells protein 4). The synthetic peptide was post-synthetically modified and conjugated to KLH to achieve desired antigenicity.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.74-0.90 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P24001

Overview

Cytokine that may play a role in innate and adaptive immune responses

Molecular Function

Cytokine

Subcellular Location

extracellular space;membrane

Expression

lymphocytes

Alternative Nomenclature

IL 32alpha antibody

IL 32beta antibody

IL 32delta antibody

IL 32gamma antibody

IL-32 antibody

Interleukin 32 antibody

Interleukin 32 small antibody

Interleukin 32 theta antibody

Interleukin-32 antibody

interleukin-32 eta antibody

Natural killer cell transcript 4 antibody

NK4 antibody

TAIF antibody

TAIFa antibody

TAIFb antibody

TAIFc antibody

TAIFd antibody

Tumor necrosis factor alpha-inducing factor antibody

General Information

Product

MAP3K8 Antibody

Description

Affinity Purified Mitogen-activated protein kinase kinase kinase 8 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-467 on human MAP3K8 protein.

Accession #

GenBank: AAI13567.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.62-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P41279

Overview

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm

Expression

Expressed in several normal tissues and human tumor-derived cell lines.

Structure

Forms a ternary complex with NFKB1/p105 and TNIP2. Interacts with NFKB1; the interaction increases the stability of MAP3K8 but inhibits its MEK phosphorylation activity, whereas loss of interaction following LPS stimulation leads to its degradation. Interacts with CD40 and TRAF6; the interaction is required for ERK activation. Interacts with KRS2; the interaction inhibits ERK and NF-kappa-B activation.

Alternative Nomenclature

c COT antibody

Cancer Osaka thyroid oncogene antibody

COT antibody

COT proto oncogene serine/threonine protein kinase antibody

EST antibody

ESTF antibody

Ewing sarcoma transformant antibody

FLJ10486 antibody

MEKK8 antibody

Mitogen activated protein kinase kinase kinase 8 antibody

Proto oncogene cCot antibody

Serine/threonine-protein kinase cot antibody

TPL 2 antibody

Tumor progression locus 2 antibody

General Information

Product

MUC1 Antibody

Description

Affinity Purified Mucin 1, transmembrane Antibody

Verified Applications

ELISA, IHC, IP

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on MUCIN1 protein.

Accession #

NCBI:  NM_182741.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P15941

Overview

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.

Molecular Function

transcription cofactor activity

Subcellular Location

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

Expression

Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only.

Alternative Nomenclature

ADMCKD antibody

Breast carcinoma-associated antigen DF3 antibody

CA 15 3 antibody

CD227 antigen antibody

DF3 antigen antibody

EMA antibody

Episialin antibody

Epithelial basement membrane antigen antibody

H23 antigen antibody

KL 6 antibody

MAM 6 antibody

MCD antibody

MCKD1 antibody

MUC 1 antibody

Peanut-reactive urinary mucin antibody

Polymorphic epithelial mucin antibody

Tumor associated epithelial membrane antigen antibody

General Information

Product

Phospho-ACK1 Antibody Antibodyd

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-300 on ACK1 protein. 

Accession #

GenBank: AAL55732.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P13749

Overview

Plays a role in presenting foreign antigens to the immune system.

Molecular Function

peptide antigen bonding

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Heterodimer of an alpha chain and a beta chain

Alternative Nomenclature

Acetate kinase 1 antibody

ACK 1 antibody

ACK antibody

Activated Cdc42 associated kinase 1 antibody

Activated p21cdc42Hs kinase antibody

FLJ44758 antibody

FLJ45547 antibody

p21cdc42Hs antibody

TNK 2 antibody

Tyrosine kinase non receptor 2 antibody