General Information

Product

CRMP1 Antibody

Description

Affinity Purified Collapsin response mediated protein 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to 80-130 on CRMP1 protein.

Accession #

GenBank: EDL37524.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.53-0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI0001548EB3

Overview

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Molecular Function

Neuron Development; Pyrimidine nucleobase catabolic process

Subcellular Location

Cytoplasm; Dendrite; Neuronal cell body

Alternative Nomenclature

Collapsin response mediator protein 1 antibody

CRMP 1 antibody

Dihydropyrimidinase like 1 antibody

Dihydropyrimidinase related protein 1 antibody

DPYSL1 antibody

DRP 1 antibody

ULIP-3 antibody

Unc-33-like phosphoprotein 3 antibody

General Information

Product

CRMP2 Antibody

Description

Affinity Purified Collapsin response mediated protein 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken from within the region corresponding to AA 60-115 of the CRMP2 protein. The 26mer peptide was conserved in several other species. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero-bifunctional cross linker for immunogen preparation.

Accession #

NCBI: NP_001184222.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: Tris glycine, Tris HCl, 30% Glycerol, 0.5% BSA, HEPES

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500. Detects a band of approximately 64 kDa in PC-CRMP2 samples. In Jurkat cells, the antibody labels a smaller band (MW 54-56 kDa), the identity of this protein is not known, but may represent a splice variant or proteolysis product of CRMP2 protein.

Protein

Uniprot #

Q16555

Overview

Involved in neuronal development and polarity, axon growth and guidance,  neuronal growth cone collapse,  and cell migration.  Is needed for signalling by class 3 semaphorins and later remodeling of the cytoskeleton.

Molecular Function

Dihydropyrimidinase activity; developmental protein

Subcellular Location

Cytoplasm; Cytoskeleton; Membrane

Expression

Ubiquitous

Structure

Homotetramer and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5.  Intteracts via its C-terminus with the C-terminus of CYF1P1/SRA1.  Also interacts with HTR4, CLN6 and MICALL1.

Alternative Nomenclature

CRAM antibody

DHPRP 2 antibody

Dihydropyrimidinase 2 antibody

DPYL 2 antibody

Musunc 33 antibody

N2A3 antibody

TOAD 64 antibody

ULIP 2 protein antibody

Unc-33-like phosphoprotein 2 antibody

General Information

Product

CXCR4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 15-65 on CXCR4 protein.

Accession #

GenBank:  CAA12166

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P61073

Overview

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Molecular Function

Host-virus Interaction

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome

Expression

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Structure

Monomer. Can form dimers.

Alternative Nomenclature

C-X-C chemokine receptor type 4 antibody

CD184 antibody

Chemokine CXC Motif Receptor 4 antibody

CXCR4 antibody

D2S201E antibody

FB22 antibody

Fusin antibody

HM89 antibody

HSY3RR antibody

LAP 3 antibody

LCR1 antibody

LESTR antibody

Leukocyte derived seven transmembrane domain receptor antibody

Lipopolysaccharide associated protein 3 antibody

Neuropeptide Y receptor Y3 antibody

NPY3R antibody

NPYR antibody

NPYRL antibody

Probable G protein coupled receptor lcr1 homolog antibody

SDF 1 receptor antibody

Stromal cell derived factor 1 receptor antibody

WHIM antibody

General Information

Product

DCC Antibody

Description

Affinity Purified Netrin Receptor DCC Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43146

Overview

Receptor for netrin required for axon guidance; may trigger signaling for axon repulsion; acts as a dependence receptor required for apoptosis induction; tumor suppressor gene.

Molecular Function

netrin receptor activity; transcription coactivator activity; transmembrane signaling receptor activity; Developmental protein

Subcellular Location

axon; cytosol; plasma membrane

Expression

Found in axons of the central and peripheral nervous system; differentiated cell types of the intestine

Structure

Belongs to the immunoglobulin superfamily. DCC family; Contains 6 fibronectin type-III domains; Contains 4 Ig-like C2-type (immunoglobulin-like) domains

Alternative Nomenclature

Colorectal cancer related chromosome sequence 18 antibody

CRC 18 antibody

CRCR 1 antibody

DCC antibody

Deleted in colorectal cancer protein antibody

Immunoglobulin superfamily DCC subclass member 1 antibody

Netrin receptor DCC antibody

Tumor suppressor protein DCC antibody

General Information

Product

DISC1 Antibody

Description

Affinity Purified Disrupted in Schizophrenia 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 730-750 on DISC1 protein.

Accession #

GenBank:  CAI17205

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.76 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q5T409

Overview

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus.

Molecular Function

Neurogenesis, Wnt signaling pathway

Subcellular Location

Membrane, Microtubule, Postsynaptic cell membrane, Synapse

Expression

Ubiquitous.

Alternative Nomenclature

C1orf136 antibody

KIAA0457 antibody

RP4-730B13.1 antibody

SCZD9 antibody

General Information

Product

C1orf187 Antibody

Description

Affinity Purified Draxin Antibody

Verified Applications

ELISA, ICC WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat, Chicken

Predicted: Bovine, Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 300-330 on C terminal region of Human Draxin protein.

Region:

NNKCFDDCMC VEGLRCYAKF HRNRRVTRRK

Accession #

NCBI: NP_940947.3

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8NBI3

Overview

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures.

Molecular Function

Wnt signaling pathway

Subcellular Location

Secreted

Structure

Interacts with LRP6

Alternative Nomenclature

AGPA3119 antibody

Chromosome 1 open reading frame 187 antibody

Dorsal inhibitory axon guidance protein antibody

Dorsal repulsive axon guidance protein antibody

FLJ34999 antibody

MGC117222 antibody

Neucrin antibody

UNQ3119 antibody

General Information

Product

CRMP3 Antibody

Description

Affinity Purified Dihydropyrimidinase related protein 4 Antibody

Verified Applications

ELISA, WB

Species Cross Reactivity

Cat, Human, Monkey, Mouse, Pig, Rat

Immunogen

Synthetic peptide corresponding to amino acids 509-527 of Mouse CRMP3. The peptide was covalently modified to achieve the desired antigenicity before coupling to carrier protein.

Sequence:

PAKPGSGTQARASCSGKIS

Accession #

NCBI: NP_006417.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:450

Protein

Uniprot #

O14531

Overview

Necessary for signaling by class 3 semaphorins and subsequent remodeling of cytoskeleton.  Plays a role in axon guidance, neuronal growth cone collapse and cell migration.

Molecular Function

Axon guidance; pyrimidine nucelobase catabolic process; Nervous system development

Subcellular Location

Cytoplasm

Structure

Homotetramer.

Alternative Nomenclature

Collapsin response mediator protein 3 antibody

DPYSL4 antibody

DRP4 antibody

ULIP 4 antibody

UNC33 like phosphoprotein 4 antibody

General Information

Product

GPR56 Extracellular domain Antibody

Description

Affinity Purified G-protein coupled receptor 56 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse

Predicted: Rat

Immunogen

Synthetic peptide taken from large extracellular loop of the human GPCR56 protein. Peptide was conjugated to Keyhole Limpet Haemocyanin (KLH).

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q9Y653

Overview

Involved in cell adhesion and probably in cell-cell interactions.

Molecular Function

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane, Secreted

Expression

highest levels found in thyroid gland, brain and heart;Expressed in a great number of tumor cells.

Structure

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily

Alternative Nomenclature

7 transmembrane protein with no EGF like N terminal domains 1 antibody

BFPP antibody

DKFZp781L1398 antibody

EGF TM7 like antibody

G protein coupled receptor 56 antibody

Gpr56 antibody

Polymicrogyria bilateral frontoparietal antibody

Protein TM7XN1 antibody

TM7LN4 antibody

TM7XN1 protein antibody

General Information

Product

LIMK1 Antibody

Description

Affinity Purified LIM domain kinase 1 isoform 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 550-647 on human LIM Kinase 1 protein.

Accession #

NCBI:  NP_002305.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P53667

Overview

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways.

Molecular Function

ATP binding, protein kinase activity, protein serine/threonine kinase activity, zinc ion binding, heat shock protein binding

Subcellular Location

Cytoplasm, nucleus

Expression

Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Alternative Nomenclature

LIM domain kinase 1 antibody

LIM motif-containing protein kinase antibody

LIMK antibody

LIMK-1 antibody

General Information

Product

MSX1 Antibody 

Description

Affinity Purified MSX1 protein Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide:

DEEGAKPKVSPSLLPFSVE

corresponding to amino acids 46-64 of Mouse Msx1 protein. The peptide was post synthetically modified and conjugated to KLH using hetero bifunctional cross linker for immunization of rabbits. 

Accession #

GenBank: AAH67353.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

P28360

Overview

Acts as a transcriptional repressor;play a role in limb-pattern formation,cranofacial development and odontogenesis

Molecular Function

Developmental protein, Repressor

Subcellular Location

Nucleus

Expression

Expressed in the developing nail bed mesenchyme.

Structure

Belongs to the Msh homeobox family

Alternative Nomenclature

AA675338 antibody

AI324650 antibody

Homeobox protein Hox-7 antibody

Homeobox protein MSX 1 antibody

HOX 7 antibody

HYD 1 antibody

msh (Drosophila) homeo box homolog 1

Msh antibody

MSX 1 antibody

OFC5 antibody

STHAG1 antibody