General Information

Product

TNFAIP3 Antibody

Description

Affinity Purified Tumor necrosis factor alpha-induced protein 3 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 690-790 on human Tumor necrosis factor alpha-induced protein 3.

Accession #

GenBank: AAA51550.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.56-0.62 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P21580

Overview

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitnase funcitons.  Participates in immune and inflammatory responses signaled by cytokines such as TNF-alpha and IL-1 beta or Toll-like receptors through terminating NF-kappa-B activity.

Molecular Function

Hydrolase, Ligas, Protease, Thiol protease

Subcellular Location

Cytoplasm; Nucleus; Lysosome

Expression

Induced by TNF

Structure

Homodimer

Alternative Nomenclature

A20 antibody

OTU domain containing protein 7C antibody

OTUD7C antibody

Putative DNA binding protein A20 antibody

TNAP3_HUMAN antibody

TNF alpha-induced protein 3 antibody

TNFA1P2 antibody

TNFAIP 3 antibody

Tumor necrosis factor alpha induced protein 3 antibody

Tumor necrosis factor inducible protein A20 antibody

Zinc finger protein A20 antibody

General Information

Product

ACTH Antibody

Description

Affinity Purified Adrenocorticotropin Hormone Antibody

Verified Applications

ELISA, IHC-Fr, IHC-P, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Predicted: Chicken, Chimpanzee, Cow, Dog, Goat, Guinea pig, Macaque Monkey, Orangutan, Sheep

Immunogen

Synthetic peptide corresponding to ACTH aa 138-176. 

Sequence:

SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF

Accession #

NCBI:  AAX36901

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.67-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Immunocytochemistry

1:250

Immunofluorescence

1:200

Immunohistochemistry

1:250

Immunoprecipitation

1:200

Western Blot

1:1000 Predicted Molecular weight: 29 kDa

Protein

Uniprot #

UPI00004EBE53

Overview

Stimulates adrenal glands and release cortisol.

Molecular Function

GPCR; Hormone activity

Subcellular Location

Secreted

Expression

ACTH and MSH are produced by the pituitary gland

Structure

Belongs to POMC family

Alternative Nomenclature

Alpha Melanocyte Stimulating Hormone antibody

Beta Endorphin antibody

Beta Lipotropin antibody

Beta Melanocyte Stimulating Hormone antibody

Beta-endorphin antibody

CLIP antibody

Corticotropin Like Intermediary Peptide antibody

Met-enkephalin antibody

MSH antibody

NPP antibody

Opiomelanocortin prepropeptide antibody

POC antibody

POMC antibody

Tetracosactide antibody

General Information

Product

ANGPTL5 Antibody

Description

Affinity Purified Angiopoietin-related protein 5 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 340-388 on human ANGPTL5 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.66 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q86XS5

Overview

Growth factors specific for vascular endothelium.  Modulate angiogenesis and maintain vascular integrity.

Molecular Function

Secreted; extracellular region

Expression

Mainly expressed in adult heart

Structure

Contains 1 fibrinogen C-terminal domain

Alternative Nomenclature

Fibrinogen like antibody

General Information

Product

CRMP1 Antibody

Description

Affinity Purified Collapsin response mediated protein 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to 80-130 on CRMP1 protein.

Accession #

GenBank: EDL37524.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.53-0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI0001548EB3

Overview

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Molecular Function

Neuron Development; Pyrimidine nucleobase catabolic process

Subcellular Location

Cytoplasm; Dendrite; Neuronal cell body

Alternative Nomenclature

Collapsin response mediator protein 1 antibody

CRMP 1 antibody

Dihydropyrimidinase like 1 antibody

Dihydropyrimidinase related protein 1 antibody

DPYSL1 antibody

DRP 1 antibody

ULIP-3 antibody

Unc-33-like phosphoprotein 3 antibody

General Information

Product

CTGF Antibody

Description

Affinity Purified Connective Tissue Growth Factor Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-350 on human CTGF protein.

Accession #

GenBank: CAG46534.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.66 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6FHL8

Overview

Involved in the regulation of cell growth

Molecular Function

Regulation of cell growth

Subcellular Location

Extracellular region

Expression

Testis, spleen, kidney, lung, heart, and brain (lowest level in testis and highest in lung).

Structure

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Alternative Nomenclature

CCN 2 antibody

Connective Tissue Growth Factor antibody

CTGF antibody

Hcs24 antibody

Hypertrophic chondrocyte specific protein 24 antibody

IBP-8 antibody

IGF-binding protein 8 antibody

Insulin like Growth Factor Binding Protein 8 antibody

MGC102839 antibody

NOV 2 antibody

General Information

Product

DCC Antibody

Description

Affinity Purified Netrin Receptor DCC Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43146

Overview

Receptor for netrin required for axon guidance; may trigger signaling for axon repulsion; acts as a dependence receptor required for apoptosis induction; tumor suppressor gene.

Molecular Function

netrin receptor activity; transcription coactivator activity; transmembrane signaling receptor activity; Developmental protein

Subcellular Location

axon; cytosol; plasma membrane

Expression

Found in axons of the central and peripheral nervous system; differentiated cell types of the intestine

Structure

Belongs to the immunoglobulin superfamily. DCC family; Contains 6 fibronectin type-III domains; Contains 4 Ig-like C2-type (immunoglobulin-like) domains

Alternative Nomenclature

Colorectal cancer related chromosome sequence 18 antibody

CRC 18 antibody

CRCR 1 antibody

DCC antibody

Deleted in colorectal cancer protein antibody

Immunoglobulin superfamily DCC subclass member 1 antibody

Netrin receptor DCC antibody

Tumor suppressor protein DCC antibody

General Information

Product

C1orf187 Antibody

Description

Affinity Purified Draxin Antibody

Verified Applications

ELISA, ICC WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat, Chicken

Predicted: Bovine, Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 300-330 on C terminal region of Human Draxin protein.

Region:

NNKCFDDCMC VEGLRCYAKF HRNRRVTRRK

Accession #

NCBI: NP_940947.3

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8NBI3

Overview

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures.

Molecular Function

Wnt signaling pathway

Subcellular Location

Secreted

Structure

Interacts with LRP6

Alternative Nomenclature

AGPA3119 antibody

Chromosome 1 open reading frame 187 antibody

Dorsal inhibitory axon guidance protein antibody

Dorsal repulsive axon guidance protein antibody

FLJ34999 antibody

MGC117222 antibody

Neucrin antibody

UNQ3119 antibody

General Information

Product

FSH Antibody

Description

Affinity Purified Follicle stimulating hormone Antibody

Verified Applications

CM, ELISA, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-60 on human FSH protein.

Accession #

GenBank: ABD84005

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Dot Blot

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Western Blot

1:500

Protein

Uniprot #

Q1W658

Overview

Binds to activin directly and serves as an activin antagonist.  Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone.

Subcellular Location

Secreted

Structure

Monomer

Alternative Nomenclature

Follicle stimulating hormone receptor isoform 1 antibody

Follitropin receptor antibody

FSH receptor antibody

FSH-R antibody

FSHRO antibody

LGR1 antibody

MGC141667 antibody

MGC141668 antibody

ODG1 antibody

ovarian dysgenesis 1 antibody

General Information

Product

ErbB 4 Antibody

Description

Affinity Purified Receptor tyrosine-protein kinase erB-4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1225-1275 on human Receptor tyrosine-protein kinase erbB-4.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q15303

Overview

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.

Molecular Function

ATP binding; epidermal growth factor receptor binding; protein homodimerization activity; receptor signaling protein tyrosine kinase activity; transcription regulatory region DNA binding; transmembrane receptor protein tyrosine kinase activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein. ERBB4 intracellular domain: Nucleus; Mitochondrion

Expression

Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. 

Contains 1 protein kinase domain.

Alternative Nomenclature

4ICD antibody

ALS19 antibody

E4ICD antibody

EC 2.7.10.1 antibody

ERBB4 antibody

HER4 antibody

Mer4 antibody

MGC138404 antibody

Oncogene ERBB4 antibody

p180erbB4 antibody

Proto-oncogene-like protein c-ErbB-4 antibody

Receptor tyrosine protein kinase erbB 4 antibody

s80HER4 antibody

Tyrosine kinase type cell surface receptor HER4 antibodyv erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody

General Information

Product

Netrin 1 Antibody Affinity Purified

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-300 on human Netrin-1 protein.

Accession #

NCBI: NP_004813.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.62-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O95631

Overview

Netrins control guidance of CNS commissural axons and peripheral motor axons; serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis;Involved in tumorigenesis by regulating apoptosis.

Subcellular Location

Extracellular matrix, Secreted

Expression

highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).

Alternative Nomenclature

epididymis tissue protein Li 131P antibody

Netrin 1, mouse, homolog of antibody

Netrin 1-like antibody

Ntn 1 antibody

Unc6 antibody