General Information

Product

Calcitonin Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Pig, Rat

Immunogen

Synthetic peptide taken within amino acid region 43-93 on human Calcitonin protein.

Accession #

GenBank: CAA26189.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P01258

Overview

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Katacalcin is a potent plasma calcium-lowering peptide.

Molecular Function

Hormone; Calcitonin receptor binding; Identical protein binding

Subcellular Location

Secreted

Structure

Belongs to calcitonin family; Signal domain

Alternative Nomenclature

Alpha CGRP antibody

CALC1 antibody

CALCA antibody

calcitonin 1 antibody

calcitonin gene related peptide 1 antibody

Calcitonin related polypeptide alpha antibody

CGRP1 antibody

CT antibody

Katacalcin antibody

KC antibody

General Information

Product

Gastrin Antibody Affinity Purified

Description

Affinity Purified Gastrin Antibody N-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human Gastrin preprotein.

Accession #

NCBI:  NP_000796.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P01350

Overview

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Molecular Function

Hormone Activity

Subcellular Location

Secreted

Expression

Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas.

Structure

Belongs to the gastrin/cholecytosokinin family

Alternative Nomenclature

Component II antibody

G14 antibody

G17 antibody

G34 antibody

G52 antibody

G6 antibody

GAS antibody

GAST antibody

gastrin antibody

Gastrin-14 antibody

Gastrin-17 antibody

Gastrin-34 antibody

Gastrin-52 antibody

Gastrin-6 antibody

Gastrin-71 antibody

General Information

Product

Gastrin Antibody Affinity Purified

Description

Affinity Purified Gastrin Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 50-100 on human Gastrin preprotein.

Accession #

NCBI:  NP_000796.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:50-1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:50-1:200

Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P01350

Overview

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Molecular Function

Hormone Activity

Subcellular Location

Secreted

Expression

Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas.

Structure

Belongs to the gastrin/cholecytosokinin family

Alternative Nomenclature

Component II antibody

G14 antibody

G17 antibody

G34 antibody

G52 antibody

G6 antibody

GAS antibody

GAST antibody

gastrin antibody

Gastrin-14 antibody

Gastrin-17 antibody

Gastrin-34 antibody

Gastrin-52 antibody

Gastrin-6 antibody

Gastrin-71 antibody

General Information

Product

Inhibin alpha Antibody Affinity Purified

Description

Affinity Purified Inhibin alpha chain; Flags Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, 85% homology with mouse protein

Immunogen

Synthetic peptide taken within amino acid region 220-270 on human alpha Inhibin.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:20,000

ELISA

1:20,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P05111

Overview

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone

Molecular Function

Cytokine activity, hormone activity, growth factor activity, receptor binding

Subcellular Location

Secreted

Expression

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Alternative Nomenclature

A inhibin subunit precursor antibody

IHA antibody

inhA antibody

Inhibin alpha chain antibody

Inhibin alpha chain precursor antibody

General Information

Product

Inhibin alpha Antibody Affinity Purified

Description

Affinity Purified Inhibin alpha chain; Flags Antibody Extreme C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, 86% homology with mouse protein

Immunogen

Synthetic peptide taken within amino acid region 315-365 on human alpha Inhibin.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:20,000

ELISA

1:20,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P05111

Overview

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone

Molecular Function

Cytokine activity, hormone activity, growth factor activity, receptor binding

Subcellular Location

Secreted

Expression

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Alternative Nomenclature

A inhibin subunit precursor antibody

IHA antibody

inhA antibody

Inhibin alpha chain antibody

Inhibin alpha chain precursor antibody

General Information

Product

Inhibin alpha Antibody

Description

Affinity Purified Inhibin alpha chain; Flags Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey; 92% homology with mouse protein

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human alpha Inhibin.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:20,000

ELISA

1:20,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P05111

Overview

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone.

Molecular Function

Cytokine activity, hormone activity, growth factor activity, receptor binding

Subcellular Location

Secreted

Expression

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Alternative Nomenclature

A inhibin subunit precursor antibody

IHA antibody

inhA antibody

Inhibin alpha chain antibody

Inhibin alpha chain precursor antibody

General Information

Product

TIE2 Antibody

Description

Affinity Purified Tyrosine-protein kinase receptor Tie-1 isoform 2 Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 540-590 on human Tyrosine-protein kinase receptor Tie-1 isoform 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q02763

Overview

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Integral component of membrane

Expression

Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma. Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family.  Contains protein kinase domain.

Alternative Nomenclature

Angiopoietin 1 receptor antibody

CD202b antibody

Endothelial tyrosine kinase antibody

Endothelium specific receptor tyrosine kinase 2 antibody

Hyk antibody

p140 TEK antibody

TEK antibody

tek tyrosine kinase antibody

TIE 2 antibody

Tunica interna endothelial cell kinase antibody

Tyrosine kinase with Ig and EGF homology domains 2 antibody

Tyrosine protein kinase receptor TEK antibody

Tyrosine protein kinase receptor TIE 2 antibody

Venous malformations multiple cutaneous and mucosal antibody

VMCM 1 antibody

VMCM antibody

General Information

Product

GDF8 / Myostatin Antibody

Description

Affinity Purified Myostatin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 325-375 on human Myostatin.

Accession #

GenBank:  ABI48514

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q53S46

Overview

Acts specifically as a negative regulator of skeletal muscle growth.

Molecular Function

Cytokine activity; Growth factor activity; heparin binding; identical protein binding; receptor binding; transforming growth factor beta receptor binding

Subcellular Location

Secreted; cytoplasm

Structure

Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3. Belongs to the TGF-beta family.

Alternative Nomenclature

GDF 8 antibody

Growth differentiation factor 8 antibody

MSLHP antibody

MSTN antibody

myostatin antibody

OTTHUMP00000163498 antibody

General Information

Product

Insulin Receptor Antibody

Description

Affinity Purified Insulin receptor alpha and beta Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 900-950 on human Insulin receptor, transcript variant 2 protein. Cross reactive with both Insulin receptor alpha and insulin receptor beta variants.

Accession #

NCBI:  NM_001079817.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P06213

Overview

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.

Structure

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds.

Alternative Nomenclature

CD220 antibody

HHF5 antibody

HIR A antibody

INSR alpha antibody

Insulin receptor antibody

Insulin receptor subunit alpha antibody

IR antibody

HHF5 antibody

human insulin receptor antibody

Insulin receptor subunit beta antibody

IR 1 antibody

General Information

Product

Insulin Receptor Antibody

Description

Affinity Purified Insulin receptor alpha and beta Antibody Extreme C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 950-1000 on human Insulin receptor, transcript variant 2 protein.

Accession #

NCBI:  NM_001079817.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P06213

Overview

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.

Structure

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds.

Alternative Nomenclature

CD220 antibody

HHF5 antibody

HIR A antibody

INSR alpha antibody

Insulin receptor antibody

Insulin receptor subunit alpha antibody

IR antibody

HHF5 antibody

human insulin receptor antibody

Insulin receptor subunit beta antibody

IR 1 antibody