General Information

Product

SEPT5 Antibody

Description

Affinity Purified Septin-5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-350 on SEPT5 protein.

Accession #

NCBI:  NP_002679.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q99719

Overview

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion.

Molecular Function

GTPase activity, structural molecule activity, GTP binding

Subcellular Location

Cytoplasm, cytoskeleton. (Note: In platelets, found in areas surrounding alpha-granules)

Expression

Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).

Alternative Nomenclature

5 Sep antibody

CDCREL1 antibody

Cell division control related protein 1 antibody

H5 antibody

HCDCREL 1 antibody

Peanut like 1 homolog antibody

Peanut-like protein 1 antibody

Platelet glycoprotein Ib beta chain antibody

PNUTL1 antibody

SEPT5 antibody

Septin 5 antibody

General Information

Product

SEPT6 Antibody Affinity Purified

Description

Affinity Purified Septin 6 Mrna Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 370-430 on SEPT6 protein.

Accession #

Gen Bank: AF397023.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54-0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q548C9

Molecular Function

GTP binding

Subcellular Location

Septin complex

Structure

Belongs to Septin Family, Contains septin-type G (guanine nucleotide-binding) domain.

Alternative Nomenclature

KIAA0128 antibody

Nkrf antibody

RCG53214, isoform CRA_d antibody

RP5-876A24.2 antibody

SEP2 antibody

SEPT2 antibody

SEPT6/MLL FUSION GENE antibody

Septin 2 antibody

Septin 6 antibody

General Information

Product

SEPT7 Antibody Affinity Purified

Description

Affinity Purified Septin 7 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-430 on SEPT7 protein.

Accession #

Gen Bank: ABB17294.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8TC62

Molecular Function

GTP binding

Subcellular Location

Septin complex

Structure

Belongs to Septin Family, Contains septin-type G (guanine nucleotide-binding) domain.

Alternative Nomenclature

CDC10 antibody

CDC10 cell division cycle 10 homolog antibody

CDC10 protein homolog antibody

CDC3 antibody

Cell division cycle 10 antibody

E430034N22 antibody

KIAA4020 antibody

Nbla02942 antibody

SEPT7A antibody

General Information

Product

Septin 8 Antibody Affinity Purified

Description

Affinity Purified Septin-8 isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on SEPT8 protein.

Accession #

NCBI:  NP_149156.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8CHH9

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).

Molecular Function

GTP binding

Subcellular Location

Cytoplasm, cytoskeleton

Structure

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with CDK14, SEPT4, S

Alternative Nomenclature

KIAA0202 antibody

OTTHUMP00000211755 antibody

SEP2 antibody

SEPT8 antibody

Septin8 antibody

General Information

Product

MSF Antibody

Description

Affinity Purified Septin 9 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-60 on SEPT9 protein.

Accession #

Gen Bank:  AAH21192.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.69 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9UHD8

Overview

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Molecular Function

GTPase activity

Subcellular Location

Cytoplasm, cytoskeleton.

Expression

Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity.

Alternative Nomenclature

Cell division control protein septin D1 antibody

MLL septin-like fusion protein MSF-A antibody

MSF1 antibody

NAPB antibody

Ov/Br septin antibody

Ovarian/breast septin alpha antibody

PNUTL4 antibody

SeptD1 antibody

Septin 9 antibody

Septin D1 antibody

SINT1 antibody

General Information

Product

p63 Antibody

Description

Affinity Purified Tumor protein 63 isoform 6 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-100 on human p63 protein.

Accession #

NCBI:  NP_001108454

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9H3D4

Overview

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.

Molecular Function

Activator, Developmental protein, chromatin binding

Subcellular Location

Nucleus

Expression

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. 

Structure

Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L.

Alternative Nomenclature

AIS antibody

Amplified in squamous cell carcinoma antibody

B(p51A) antibody

B(p51B) antibody

Chronic ulcerative stomatitis protein antibody

CUSP antibody

DN p63 alpha 1 antibody

EEC3 antibody

Keratinocyte transcription factor antibody

KET antibody

LMS antibody

MGC115972 antibody

MGC192897 antibody

NBP antibody

OFC8 antibody

p40 antibody

p51 antibody

P51/P63 antibody

p53CP antibody

p63 antibody

P73 antibody

p73H antibody

p73L antibody

RHS antibody

SHFM4 antibody

TAp63alpha antibody

TP53CP antibody

TP53L antibody

TP63 antibody

TP73 antibody

Transformation related protein 63 antibody

Trp53rp1 antibody

Trp63 antibody

Tumor protein 63 antibody

Tumor protein p53-competing protein antibody

Tumor protein p63 deltaN isoform delta antibody

Tumor protein p73 antibody

General Information

Product

UFD1L Antibody Affinity Purified

Description

Affinity Purified UFD1L Purified 20 kDa UFD1L protein Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Purified 20 kDa UFD1L protein

Accession #

GenBank: CAG30493.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q92890

Overview

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins  from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Molecular Function

Ubiquitin-specific protease activity

Subcellular Location

Nucleus; Cytosol

Expression

Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.

Structure

Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13.

Alternative Nomenclature

UB fusion protein 1 antibody

Ubiquitin fusion degradation 1 like (yeast) antibody

Ubiquitin fusion degradation protein 1 homolog antibody

UFD1 antibody

UFD1L antibody

General Information

Product

Phospho-Histone H3 Antibody (S10)

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Phosphorylated synthetic peptide taken within amino acid region 1-50 on HH3 protein.

Accession #

GenBank: CAA58540.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P68431

Overview

Core component of nucleosome.Play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Molecular Function

DNA-binding

Subcellular Location

Nucleus; Chromosome

Expression

During Sphase, then expression decreases as cell division slows down during the process of differentiation.

Structure

Belongs to histone H3 family

Alternative Nomenclature

H3.3B antibody

H3F3A antibody

H3 histone antibody

H3 histone family member E pseudogene antibody

HIST3H3 antibody

Histone H3 3 pseudogene antibody

PP781 antibody

General Information

Product

CXCR2 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, FC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide:

EDLSNYSYSSTLPPFLLDAAPC

Corresponding to amino acids 18-39 of Human CXCR2.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:250

Western Blot

1:500 Predicted molecular weight: 55 kDa

Protein

Uniprot #

P25025

Overview

Receptor for interleukin-8, binding of IL-8 to the receptor causes the activation of neutrophils.  This response is mediated by a G-protein which activates a phosphatidyinositol-calcium second messenger system.

Molecular Function

G-Protein coupled receptor, Transducer, chemokine receptor activity

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Up-regulated by CREB3

Structure

Binds to HIV-1 Tat and interacts with ARRB1

Alternative Nomenclature

C-X-C chemokine receptor type 2 antibody

CD 182 antibody

CD182 antigen antibody

CDw128b antibody

Chemokine (CXC) receptor 2 antibody

CMKAR2 antibody

CXCR2 antibody

GRO/MGSA receptor antibody

High affinity interleukin-8 receptor B antibody

IL8R B antibody

IL8R2 antibody

IL8RA antibody

Interleukin 8 receptor, beta antibody

Interleukin 8 receptor, type 2 antibody

General Information

Product

CXCR2 Antibody Affinity Purified

Description

Affinity Purified IL8 Receptor beta Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, FC, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

C-epitope Synthetic peptide corresponding to unique amino acid sequences on IL8 Receptor beta protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P41597

Overview

Receptor for CCL2, CCL7 and CCL13 chemokines.  Transudces a signal via increasing intracellular calcium ion levels.

Molecular Function

G-Protein coupled receptor, Transducer, chemokine receptor activity

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Up-regulated by CREB3

Structure

Binds to HIV-1 Tat and interacts with ARRB1

Alternative Nomenclature

C-X-C chemokine receptor type 2 antibody

CD 182 antibody

CD182 antigen antibody

CDw128b antibody

Chemokine (CXC) receptor 2 antibody

CMKAR2 antibody

CXCR2 antibody

GRO/MGSA receptor antibody

High affinity interleukin-8 receptor B antibody

IL8R B antibody

IL8R2 antibody

IL8RA antibody

Interleukin 8 receptor, beta antibody

Interleukin 8 receptor, type 2 antibody