General Information

Product

IL32 Antibody

Description

Affinity Purified Interleukin-32 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 180-234 on human Interleukin-32 (natural killer cells protein 4). The synthetic peptide was post-synthetically modified and conjugated to KLH to achieve desired antigenicity.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.74-0.90 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P24001

Overview

Cytokine that may play a role in innate and adaptive immune responses

Molecular Function

Cytokine

Subcellular Location

extracellular space;membrane

Expression

lymphocytes

Alternative Nomenclature

IL 32alpha antibody

IL 32beta antibody

IL 32delta antibody

IL 32gamma antibody

IL-32 antibody

Interleukin 32 antibody

Interleukin 32 small antibody

Interleukin 32 theta antibody

Interleukin-32 antibody

interleukin-32 eta antibody

Natural killer cell transcript 4 antibody

NK4 antibody

TAIF antibody

TAIFa antibody

TAIFb antibody

TAIFc antibody

TAIFd antibody

Tumor necrosis factor alpha-inducing factor antibody

General Information

Product

Nurr1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. 

Sequence:

CTQGLQRIFYLKLEDLVPPPAIIDKL

Accession #

GenBank: BAA75666.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43354

Overview

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development.

Molecular Function

Receptor

Subcellular Location

Cytoplasm, Nucleus

Expression

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Structure

Belongs to the nuclear hormone receptor family. NR4 subfamily.

Alternative Nomenclature

HZF 3 antibody

Immediate-early response protein NOT antibody

NGFI B/nur77 beta type transcription factor homolog antibody

NOT antibody

NR4A2 antibody

Nur related protein 1 homolog antibody

Nurr 1 antibody

Orphan nuclear receptor NR4A2 antibody

RNR1 antibody

T cell nuclear receptor NOT antibody

TINUR antibody

Transcriptionally inducible nuclear receptor antibody

General Information

Product

TREX1 Antibody

Description

Affinity Purified Three-prime repair exonuclease 1 Antibody

Verified Applications

ELISA, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 220-245 on human TREX1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NSU2

Overview

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements.

Molecular Function

Exonucleus, Hydrolase, Nuclease

Subcellular Location

Nucleus, Cytoplasm, Endoplasmic reticulum membrane; Peripheral membrane protein

Expression

Detected in thymus, spleen, liver, brain, heart, small intestine and colon.

Structure

Homodimer. Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, directly interacts with SET; this interaction does not result in TREX1 inhibition.

Alternative Nomenclature

3' 5' exonuclease TREX1 antibody

3' repair exonuclease 1 antibody

AGS1 antibody

AGS5 antibody

CRV antibody

Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody

DKFZp434J0310 antibody

DNase III antibody

DRN3 antibody

HERNS antibody

Three prime repair exonuclease 1 antibody

TREX1 antibody

General Information

Product

Viral Protein U Antibody

Description

Affinity Purified VPU Antibody

Verified Applications

CM, ELISA, Flow cytometry, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human Immunodeficiency Virus 1

Immunogen

Synthetic peptide taken within amino acid region 58-80 on VPU peptide. Synthetic peptide is covalently modified.

Sequence:

EGDQEELSALMEMGHHAPWNVND

Accession #

GenBank: BAD20654.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q6L8A2

Overview

Cation Channel activity, Receptor Catabolic process, Viral release from host cell

Subcellular Location

Host cell membrane

Alternative Nomenclature

U ORF protein antibody

Vpu antibody

General Information

Product

SOCS1 Antibody

Description

Affinity Purified Suppressor of Cytokine Signaling 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 170-212 on human Suppressor of Cytokine signaling 1 protein.

Accession #

GenBank: CAA27974.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P13848

Overview

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Molecular Function

Insulin-like  growth factor receptor binding; Protein kinase binding; Kinase inhibitor activity

Subcellular Location

Nucleus; Cytoplasmic vesicle

Expression

Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Structure

Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC (SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with AXL, CUL2 and FGFR3. Interacts with INSR.

Alternative Nomenclature

CISH 1 antibody

Cytokine Inducible SH2 Protein 1 antibody

JAB antibody

JAK-binding protein antibody

Janus kinase binding protein antibody

SOCS-1 antibody

SSI1 antibody

STAT Induced STAT Inhibitor 1 antibody

Suppressor of cytokine signaling 1 antibody

TEC Interacting Protein 3 antibody

TIP3 antibody

General Information

Product

PD-L1 Antibody

Description

Affinity Purified Programmed cell death 1 ligand 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Predicted: Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid reigon 80-130 on human Progammed cell death 1 ligand 1 protein.

Accession #

NCBI:  NP_054862

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9NZQ7

Overview

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Molecular Function

Receptor

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Endomembrane system; Single-pass type I membrane protein

Expression

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Structure

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative Nomenclature

B7 H antibody

B7 homolog 1 antibody

CD 274 antibody

PD L1 antibody

PDCD1 ligand 1 antibody

PDCD1L1 antibody

PDCD1LG1 antibody

PDL 1 antibody

Programmed death ligand 1 antibody

RGD1566211 antibody