General Information

Product

SERHL Antibody Affinity Purified

Description

Affinity Purified Serine hydrolase-like protein 2 isoform a Antibody C-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresonding to unique amino acid sequence on human serine hydrolase 1 protein.

Accession #

NCBI:  NP_055324.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.40-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Western Blot

1:500

Protein

Uniprot #

Q9H4I8

Overview

Probable serine hydrolase. May be related to cell muscle hypertrophy.

Molecular Function

Hydrolase activity

Subcellular Location

Cytoplasm, perinuclear region; peroxisome. (Note: Concentrated in perinuclear vesicles. May be located in peroxisomes)

Alternative Nomenclature

BK126B4.1 antibody

BK126B4.2 antibody

HS126B42 antibody

serine hyrdolase 1 antibody

General Information

Product

SERHL Antibody Antigenic Blocking Peptide

Description

Antigenic Blocking Peptide Serine hydrolase-like protein 2 isoform a Antibody N-epitope

Verified Applications

Immunodepletion, Immunocompetition

Immunogen

Synthetic peptide

Accession #

NCBI:  NP_055324.2

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q9H4I8

Overview

Probable serine hydrolase. May be related to cell muscle hypertrophy.

Molecular Function

Hydrolase activity

Subcellular Location

Cytoplasm, perinuclear region; peroxisome. (Note: Concentrated in perinuclear vesicles. May be located in peroxisomes)

Alternative Nomenclature

BK126B4.1 antibody

BK126B4.2 antibody

HS126B42 antibody 

serine hyrdolase 1 antibody

General Information

Product

SGK3 Antibody

Description

Affinity Purified Serine/Threonine-protein Kinase Sgk3 Antibody

Verified Applications

CM, ELISA, IC, IF, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 440-490 on human Sgk3 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q96BR1

Overview

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.

Molecular Function

ATP-binding, Nucleotide binding; Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasmic vesicle; Early endosome; Recycling endosome

Expression

Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors.

Structure

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Contains 1 PX (phox homology) domain.

Alternative Nomenclature

CISK antibody

Cytokine independent survival kinase antibody

DKFZp781N0293 antibody

Serine/threonine protein kinase Sgk3 antibody

Serum/glucocorticoid regulated kinase family member 3 antibody

Serum/glucocorticoid-regulated kinase 3 antibody

SGK 3 antibody

Sgk3 antibody

SGKL antibody

General Information

Product

SERINC1 Antibody

Description

Affinity Purified Serine incorporator 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Pig, Rat

Predicted: Mouse

Immunogen

Synthetic peptide taken within amino acid region 250-310 on human Serine inorporator 1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9NRX5

Overview

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Endoplasmic reticulum membrane

Structure

Belongs to the TDE1 family

Alternative Nomenclature

1500011D18Rik antibody

AI315070 antibody

AIGP 2 antibody

KIAA1253 antibody

LRRGT00191 antibody

mKIAA1253 antibody

SERINC1 antibody

Serine incorporator 1 antibody

TDE1L antibody

TDE2 antibody

TMS 2 antibody

Tumor differentially expressed 1 protein like antibody

Tumor differentially expressed protein 2 antibody

UNQ396/PRO732 antibody

General Information

Product

SERINC4 Antibody

Description

Affinity Purified Serine incorporator 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 350-400 on human Serine incorporator 4 protein.

Accession #

NCBI: NP_001244960

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

A6NH21

Overview

Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Membrane; Multi-ass membrane protein

Structure

Belongs to the TDE1 family

Alternative Nomenclature

FLJ40363 antibody

SERC4_HUMAN antibody

SERINC4 antibody

Serine incorporator 4 antibody

General Information

Product

SERINC5 Antibody

Description

Affinity Purified Serine incorporator 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 270-320 on human Serine incorporator 5 protein.

Accession #

NCBI:  XP_011541606

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

UPI0005D01C8F

Overview

Restriction factor required to restrict infectivity of gammaretroviruses, such as HIV-1: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Cell membrane; Multi-pass membrane

Expression

Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain.

Structure

Belongs to the TDE1 family

Alternative Nomenclature

C5orf12 antibody

SERC5_HUMAN antibody

SERINC5 antibody

Serine incorporator 5 antibody

TPO1 antibody

General Information

Product

Indoleamine 2, 3-dioxygenase 2 Antibody

Description

Affinity Purified Indoleamine 2,3-dioxygenase 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 370-420 on human Indoleamine 2,3-dioxygenase 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q6ZQW0

Overview

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance.

Molecular Function

heme binding

indoleamine 2,3-dioxygenase activity

metal ion binding

tryptophan 2,3-dioxygenase activity

Subcellular Location

cytosol

Expression

Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%).

Structure

Belongs to the indoleamine 2,3-dioxygenase family.

Alternative Nomenclature

3-dioxygenase antibody

I23O1_HUMAN antibody

IDO 2 antibody

IDO antibody

IDO-2 antibody

IDO2 antibody

INDO antibody

indolamine 2,3 dioxygenase antibody

Indole 2 3 dioxygenase antibody

indoleamine 2 3 dioxygenase 1 antibody

indoleamine 2 3 dioxygenase antibody

Indoleamine 2,3-dioxygenase 1 antibody

Indoleamine pyrrole 2 3 dioxygenase antibody

Indoleamine-pyrrole 2 antibody

General Information

Product

Indoleamine 2, 3-dioxygenase 1 Antibody

Description

Affinity Purified Indoleamine 2,3-dioxygenase 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human Indoleamine 2,3-dioxygenase 1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P14902

Subcellular Location

cytosol

Expression

Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885).

Structure

Belongs to the indoleamine 2,3-dioxygenase family.

Alternative Nomenclature

3-dioxygenase antibody

I23O1_HUMAN antibody

IDO antibody

IDO1 antibody

INDO antibody

indolamine 2,3 dioxygenase antibody

Indole 2 3 dioxygenase antibody

indoleamine 2 3 dioxygenase 1 antibody

indoleamine 2 3 dioxygenase antibody

Indoleamine 2,3-dioxygenase 1 antibody

Indoleamine pyrrole 2 3 dioxygenase antibody

Indoleamine-pyrrole 2 antibody

General Information

Product

LRRK1 Antibody

Description

Affinity Purified Leucine-rich repeat serine/threonine-protein kinase 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1950-2015 on human Leucine-rich repeat serine/threonine-protein kinase 1  protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q38SD2

Overview

ATP + a protein = ADP + a phosphoprotein.

Molecular Function

ATP binding

GTP binding

identical protein binding

metal ion binding

protein serine/threonine kinase activity

signal transducer activity

Subcellular Location

Cytoplasm

Expression

Homodimer.

Structure

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.

Alternative Nomenclature

KIAA1790 antibody

Leucine rich repeat serine/threonine protein kinase 1 antibody

Lrrk1 antibody

RIPK6 antibody

Roco1 antibody