General Information

Product

SEC23 Antibody

Description

Affinity Purified Protein transfer protein Sec23A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster, Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 700-765 on human SEC23A protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:350

Western Blot

1:500

Protein

Uniprot #

Q15436

Overview

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.

Molecular Function

ER to Golgi vesicle-mediated transport; Intracellular protein transport; Zinc ion binding

Subcellular Location

COPII vesicle coat; Cytoplasm; Endoplasmic Reticulum Membrane; Golgi Apparatus Membrane; Peripheral Membrane Protein

Structure

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SLC6A4. Interacts with SEC16A.

Alternative Nomenclature

CLSD antibody

Protein transport protein Sec23A antibody

SEC23-related protein A antibody

General Information

Product

Phospho-PDE10A Antibody

Description

Affinity Purified Phosphorylated Phosphodiesterase 10A Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Phosphorylated synthetic MAP common to all PDE10A variants.  Taken within amino acid region 1-50 on human PDE10A protein.

Accession #

GenBank: AAD32596.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9Y233

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.

Molecular Function

Hydrolase, metal-ion binding, cGMP binding

Subcellular Location

Cytoplasm

Expression

Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.

Structure

Homodimer

Alternative Nomenclature

5''-cyclic phosphodiesterase 10A antibody

cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A antibody

FLJ11894 antibody

HSPDE10A antibody

PDE 10A antibody

Pde10a antibody

Phosphodiesterase 10A antibody

General Information

Product

PDE8A Antibody

Description

Affinity Purified Pan Phosphodiesterase 8A Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic cyclic peptide from near the N terminus common to all PDE8A variants.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500-1:2,000

Protein

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity, Hydrolase, Metal-binding

Subcellular Location

Cytosol

Expression

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Structure

Belongs to cyclic nucleotide phosphodiesterase family. PDE8B subfamily.  Contains 1 PAC (Pas-associated C-terminal) domain.  Contains 1 PAS (PER-ARNT-SIM) domain.

Alternative Nomenclature

5''-cyclic phosphodiesterase 8A antibody

cAMP specific cyclic nucleotide phosphodiesterase 8A antibody

FLJ16150 antibody

High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody

HsT19550 antibody

PDE 8A antibody

Phosphodiesterase 8A antibody

Weakly similar to 3'5'-cyclic-nucleotide phosphodiesterase antibody

General Information

Product

PDE8A Antibody

Description

Affinity Purified Pan Phosphodiesterase 8A Antibody Mid-Region

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic cyclic peptide from mid-region common to all PDE8A variants.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500-1:2,000

Protein

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity, Hydrolase, Metal-binding

Subcellular Location

Cytosol

Expression

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Structure

Belongs to cyclic nucleotide phosphodiesterase family. PDE8B subfamily.  Contains 1 PAC (Pas-associated C-terminal) domain.  Contains 1 PAS (PER-ARNT-SIM) domain.

Alternative Nomenclature

5''-cyclic phosphodiesterase 8A antibody

cAMP specific cyclic nucleotide phosphodiesterase 8A antibody

FLJ16150 antibody

High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody

HsT19550 antibody

PDE 8A antibody

Phosphodiesterase 8A antibody

Weakly similar to 3'5'-cyclic-nucleotide phosphodiesterase antibody

General Information

Product

PDE8A Antibody

Description

Affinity Purified Pan Phosphodiesterase 8A Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic cyclic peptide from C terminus common to all PDE8A variants.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity, Hydrolase, Metal-binding

Subcellular Location

Cytosol

Expression

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Structure

Belongs to cyclic nucleotide phosphodiesterase family. PDE8B subfamily.  Contains 1 PAC (Pas-associated C-terminal) domain.  Contains 1 PAS (PER-ARNT-SIM) domain.

Alternative Nomenclature

5''-cyclic phosphodiesterase 8A antibody

cAMP specific cyclic nucleotide phosphodiesterase 8A antibody

FLJ16150 antibody

High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody

HsT19550 antibody

PDE 8A antibody

Phosphodiesterase8A antibody

Weakly similar to 3'5' cyclic nucleotide phosphodiesterase antibody

General Information

Product

CCR4 Antibody

Description

Affinity Purified C-C chemokine receptor type 4 Antibody

Verified Applications

CF, DB, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 4 protein.

Accession #

NCBI: NP_005499

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P51679

Overview

Receptor for C-C type chemokines CCL17/TARC and CCL22/MDC.  Functions as chemoattractant homing receptor on circulating memory lymphocytes and as coreceptor for some primary HIV-2 isolates.  Can also mediate hippocampal-neuron survival.

Molecular Function

GPCR, Receptor, Transducer.

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Thymus, peripheral blood leukocytes including T-cells, CD4+ cells, basophils and in platelets.  Expressed less in spleen and in monocytes.  Also found in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expresseding cutaneous lymphocyte antigen.  Expressed in brain and microvascular and coronary artery endothelial cells.

Structure

Belongs to G-protein coupled receptor 1 family.  Interacts with CREB3.

Alternative Nomenclature

CD194 antibody

ChemR13 antibody

CKR4 antibody

CMKBR 4 antibody

HGCN 14099 antibody

K5 5 antibody

General Information

Product

N-Chimaerin Antibody

Description

Affinity Purified N-Chimaerin isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on alpha 2 Chimaerin protein.

Accession #

NCBI:  NP_001813

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P15882

Overview

GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.

Molecular Function

GTPase activation

Subcellular Location

Cytosol

Expression

In neurons in brain regions that are involved in learning and memory processes.

Structure

Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.

Alternative Nomenclature

A-chimaerin antibody

Alpha-chimerin antibody

ARHGAP2 antibody

CHN antibody

Chn1 antibody

N chimaerin antibody

NC antibody

Rho GTPase-activating protein 2 antibody

RHOGAP2 antibody

General Information

Product

Chimaerin beta 3 Antibody

Description

Affinity Purified Beta-Chimaerin isoform 3 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-100 on human beta-chimaerin isoform 3 protein.

Accession #

NCBI:  NP_001279998.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P52757

Overview

GTPase-activating protein for p21-rac.  May play role in progression from low-grade to high-grade tumors.

Molecular Function

Metal binding; Zinc

Subcellular Location

Membrane

Expression

Brain, pancreas, heart, placenta.  Weakly expressed in kidney and liver.

Structure

Contains 1 phorbol-ester/DAG-type zinc finger; 1 Rho-GAP domain; 1 SH2 domain.

Alternative Nomenclature

ARHGAP3 antibody

BCH antibody

Beta chimerin antibody

Chimaerin3 antibody

CHN3 antibody

MGC138360 antibody

Rho GTPase activating protein 3 antibody

RHOGAP3 antibody

General Information

Product

CTR1 / SLC31A1 Antibody

Description

Affinity Purified High affinity copper uptake protein 1 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

N-epitope synthetic peptide corresponding to amino acids 1-50 of Human SLC31A1 / CTR1 protein.

Sequence:

MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG

Accession #

NCBI:  NP_001850.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O15431

Overview

High-affinity, saturable copper transporter involved in dietary copper uptake.

Molecular Function

Copper ion transmembrane transporter activity, copper uptake transmembrane transporter activity

Subcellular Location

Cell membrane; Multi-pass membrane protein

Structure

Homotrimer

Alternative Nomenclature

Copper transport 1 homolog 

COPT1 

CTR1 

hCTR1 

High affinity copper uptake protein 1 

SLC31A1 

Solute carrier family 31 member 1 

General Information

Product

PDE7B Antibody

Description

Affinity Purified cAMP-specific 3',5'-cyclic phosphodiesterase 7B Antibody

Verified Applications

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic cyclic peptide common to all PDE7B variants.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:250

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8VIE4

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

Molecular Function

Hydrolase, 3', 5' -cyclic-AMP phosphodiesterase activity

Subcellular Location

Cytosol

Expression

Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas.

Alternative Nomenclature

bA472E5.1 antibody

cAMP specific 3 5 cyclic phosphodiesterase 7B antibody

High affinity cAMP specific 3 5 cyclic phosphodiesterase antibody

MGC88256 antibody

PDE 7B antibody

Phosphodiesterase7B antibody

RNPDE7B antibody

Rolipram insensitive phosphodiesterase type 7 antibody