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EPAC2 Antibody

Product no.: EPAC-201AP

$320.00

General Information
Product	Epac2 Antibody
Description	Affinity Purified Rap Guanine Nucleotide Exchange Factor 3 Antibody
Verified Applications	CM, ELISA, ICC/IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rabbit, Rat
Immunogen	Synthetic peptide corresponding to amino acids 743-762 of Epac2 protein. Sequence: CPREQFDSLTPLPEQEGPT
Specificity	This antibody does not cross react with other Epac family proteins.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.67 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500. Predicted molecular weight: 112 kDa
Protein
Uniprot #	Q9Z1C7
Overview	Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
Molecular Function	Guanine-nucleotide releasing factor
Subcellular Location	Cytoplasm; Membrane; Peripheral membrane protein
Structure	Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.
Alternative Nomenclature	CAMP GEFII antibody cAMP regulated guanine nucleotide exchange factor II antibody CGEF2 antibody Epac 2 antibody Exchange protein directly activated by cAMP 2 antibody Nbla00496 antibody Putative protein product of Nbla00496 antibody Rap guanine nucleotide exchange factor (GEF) 4 antibody RAPGEF 4 antibody

Protein information supplied by UniProt

Fabgennix Epac2 Antibody has been used in 1 Publication

McPartlin, L.A., P.E. Visconti, and S.J. Bedford-Guaus. “Guanine-Nucleotide Exchange Factors (RAPGEF3/RAPGEF4) Induce Sperm Membrane Depolarization and Acrosomal Exocytosis in Capacitated Stallion Sperm.”Biology of Reproduction 85.1 (2011): 179–188. PMC3123385

Confocal Microscopy, Immunofluorescence, Western Blot; Horse, Mouse

Publishing research using EPAC-201AP? Please let us know, we can cite the reference in this datasheet.

Customer ratings for EPAC2 Antibody

Number of ratings: 1
Average rating: 4

Good
from Verified Customer on 01/04/2021

Western blot. Rabbit cell lysate- whole cell (pancreatic acini). 20µg rabbit pancreatic acini loaded on reduced denaturing (7.5%) gel. 5% BSA as blocking agent for 2 hours at 25°C.

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Accessories

Product

Note

Status

Price

EPAC2 Antibody FITC

EPAC2-FITC

$375.00 *

EPAC2 Antibody BIOTIN

EPAC2-BIOTIN

$375.00 *

EPAC2 Blocking Peptide

P-EPAC2

$155.00 *

EPAC2 Positive Control

PC-EPAC2

$200.00 *

General Information
Product	GTPase HRAS Antibody
Description	Affinity Purified Transforming p21 Ras Antibody N-epitope
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Chicken, Human, Mouse
Immunogen	Synthetic peptide taken within amino acid region 1-50 on human GTPase HRAS protein.
Accession #	NCBI: NP_005334.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	1.00-1.25 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	P01112
Overview	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Molecular Function	GTP binding, Protein C-terminus binding
Subcellular Location	Cell membrane; Lipid anchor; Cytoplasmic side; Gogli appartus membrane; Lipid-anchor
Structure	In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3. Interacts with HSPD1. Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain).
Alternative Nomenclature	c bas/has antibody c has/bas p21 protein antibody c ras Ki 2 protein antibody c-H-ras antibody CTLO antibody G1III6 N ras antibody GTP and GDP binding peptide B antibody GTPase HRas antibody H Ras 1 antibody H ras oncogene antibody H RasIDX antibody Ha Ras1 proto oncoprotein antibody HAMSV antibody Harvey rat sarcoma viral oncoprotein antibody HRAS1 antibody K ras antibody N ras antibody p19 H RasIDX protein antibody p21ras antibody Ras family small GTP binding protein H Ras antibody RASH1 antibody Transformation gene oncogene HAMSV antibody Transforming protein p21 antibody v Ha ras Harvey rat sarcoma viral oncogene homolog antibody VH Ras antibody

General Information
Product	proANP Antibody
Description	Affinity Purified Atrial natriuretic peptide receptor 3 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 100-150 on human proANP protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.60 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P01160
Overview	Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Molecular Function	Neuropeptide hormone activity; Neuropeptide receptor binding; Receptor binding; Hormone; Vasoactive
Subcellular Location	Secreted
Structure	Belongs to the natriuretic peptide family
Alternative Nomenclature	ANF antibody ANP antibody ATFB6 antibody Atrial natriuretic factor antibody Atrial natriuretic peptide antibody Atriopeptin antibody ATRST2 antibody Cardionatrin antibody CDD ANF antibody CDP antibody Natriuretic peptide A antibody Natriuretic peptide precursor A antibody NPPA antibody PND antibody Prepronatriodilatin antibody Pronatriodilatin antibody

NPRC-301AP Natriuretic Peptide Receptor C Antibody $285.00 *	PGCA-101AP PGCA Antibody $320.00 *	PGCB-201AP PGCB Antibody $320.00 *
PGCC-301AP Particulate Guanylate Cyclase C Antibody $320.00 *	PANPRA-140AP Phospho-proANP Antibody $375.00 *	PBNP-101AP proBNP Antibody $285.00 *

General Information
Product	Phospho-proANP Antibody
Description	Affinity Purified Phospho Atrial natriuretic peptide receptor 3 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on ANPR-A receptor.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-0.76 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P16066
	Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Molecular Function	Neuropeptide hormone activity; Neuropeptide receptor binding; Receptor binding; Hormone; Vasoactive
Subcellular Location	Secreted
Structure	Belongs to the natriuretic peptide family
Alternative Nomenclature	ANF antibody ANP antibody ATFB6 antibody Atrial natriuretic factor antibody Atriopeptin antibody ATRST2 antibody Cardionatrin antibody CDD ANF antibody CDP antibody Natriuretic peptide A antibody NPPA antibody PND antibody Prepronatriodilatin antibody

PANP-101AP proANP Antibody $285.00 *	PGCA-101AP PGCA Antibody $320.00 *	PGCB-201AP PGCB Antibody $320.00 *
PGCC-301AP Particulate Guanylate Cyclase C Antibody $320.00 *	NPRC-301AP Natriuretic Peptide Receptor C Antibody $285.00 *	PBNP-101AP proBNP Antibody $285.00 *

General Information
Product	Phospho Chimaerin beta 2 Antibody
Description	Affinity Purified Phosphorylated N-Chimaerin isoform 1 Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Phosphorylated synthetic peptide corresponding to unique amino acid sequence on beta 2 Chimaerin protein.
Accession #	NCBI: NP_001813
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.58-0.63 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Dot Blot	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	P15882
Overview	GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Molecular Function	GTPase activation
Subcellular Location	Cytosol
Expression	In neurons in brain regions that are involved in learning and memory processes.
Structure	Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.
Alternative Nomenclature	A-chimaerin antibody ARHGAP2 antibody CHN antibody Chn1 antibody N chimaerin antibody NC antibody Rho GTPase-activating protein 2 antibody RHOGAP2 antibody

General Information
Product	PDE1A Antibody
Description	Affinity Purified Phosphodiesterase 1A Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence within amino acid region 1-50 on PDE1A protein. Common to all PDE1A variants.
Specificity	This antibody will not label other PDE family members. This antibody will label all PDE1 variants including PDE1A1, PDE1A3, PDE1A5.
Accession #	NCBI: NP001009978.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.59 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500-1:1,000
Protein
Uniprot #	Q9JLL9
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Molecular Function	Hydrolase, calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity, metal ion binding
Subcellular Location	Cytosol
Expression	Several tissues, including brain, kidney, testes and heart.
Structure	Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Alternative Nomenclature	3' 5' cyclic nucleotide phosphodiesterase antibody 61 kDa Cam PDE antibody Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody Calcium/calmodulin-dependent 3'' antibody Calmodulin-dependent Phosphodiesterase antibody Cam PDE 1A antibody HSPDE1A antibody MGC26303 antibody PDE1A antibody Phosphodiesterase 1A antibody Phosphodiesterase 1A calmodulin dependent antibody

Fabgennix PDE1A Antibody has been used in 16 Publications
Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994	Immunohistochemistry, Western Blot; Human
Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518. PMID25550199	Western Blot; Mouse
Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654	Immunohistochemistry, Western Blot; Mouse
Ückert, Stefan, et al. "Phosphodiesterase type 1, calcitonin gene-related peptide and vasoactive intestinal polypeptide are involved in the control of Human vaginal arterial vessels." European Journal of Obstetrics & Gynecology and Reproductive Biology 169.2 (2013): 283-286. PMID23490535	Immunohistochemistry; Human
Abusnina, Abdurazzag, et al. "Anti‐prolifeRative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integRator UHRF1." Molecular nutrition & food research 55.11 (2011): 1677-1689. PMID22045655	Western Blot; Human
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350. PMID21653225	Immunofluorescence, Western Blot; Human
Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011): 152-160. PMID20807569	Western Blot; Human
Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009): 605–614. PMC2803251	Western Blot; Rat
Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, Integrative and Comparative Physiology297.5 (2009): R1469–R1476. PMID19741056	Immunoprecipitation; Mouse
Deplano, Stefania, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase during ontogenesis of chick retina." Journal of neuroscience research 86.5 (2008): 1017-1023.PMID18041092	Immunohistochemistry, Western Blot; Chicken
Albrecht, Knut, et al. "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the Human vagina: A potential forensic value?." Journal of forensic and legal medicine 14.5 (2007): 270-274. PMID17113813	Immunohistochemistry; Human
Murray, Fiona, et al. "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007): L294-L303.PMID16980375	Western Blot; Human
Santone, Rocco, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase in adult Rat retina." Journal of neuroscience research 84.5 (2006): 1020-1026. PMID16881052	Confocal Microscopy, Immunohistochemistry; Rat
SAIRENJI, Nakayasu, Keitaro SATOH, and Hiroshi SUGIYA. "Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase in cGMP metabolism in Rabbit parotid acinar cells." Biomedical Research 27.1 (2006): 37-44. PMID16543664	Western Blot; Rabbit
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425	Immunofluorescence, Western Blot; Mouse
Whitehead, Clark M., et al. "Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival." Molecular cancer therapeutics 2.5 (2003): 479-488. PMID12748310	Immunohistochemistry; Human

General Information
Product	PDE1A7 Antibody Affinity Purified
Description	Affinity Purified Calcium/Calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform PDE1A7 Antibody
Verified Applications	ELISA, IMM, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide selective only for PDE1A7 gene.
Accession #	NCBI: NP_001009978.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500-1:750
Protein
Uniprot #	Q9JLL9
Overview	A divalent metal cation
Molecular Function	Hydrolase, calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity, metal ion binding
Alternative Nomenclature	3' 5' cyclic nucleotide phosphodiesterase antibody 5''-cyclic nucleotide phosphodiesterase 1A antibody 61 kDa Cam PDE antibody Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody Cam PDE 1A antibody HCAM 1 antibody HSPDE1A antibody MGC26303 antibody PDE 1A antibody Phosphodiesterase 1A antibody

Home page Primary Antibodies Signal Transduction Second Messengers cAMP EPAC2 Antibody

Home page Primary Antibodies Signal Transduction G-Protein Coupled Receptors Ras Family GTPase HRAS Antibody

Home page Primary Antibodies Signal Transduction G-Protein Coupled Receptors Ras Family GTPase HRAS Antibody

Home page Primary Antibodies Signal Transduction G-Protein Coupled Receptors Ras Family GTPase HRAS Antibody

Home page Primary Antibodies Cardiology proANP Antibody

Home page Primary Antibodies Cardiology Phospho-proANP Antibody

Home page Primary Antibodies Signal Transduction Regulation Phospho-Chimaerin beta 2 Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cGMP PDE1A Antibody

Home page Primary Antibodies Signal Transduction Phosphodiesterases PDE1A Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cGMP PDE1A7 Antibody

EPAC2 Antibody

Customer ratings for EPAC2 Antibody

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proANP Antibody

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