General Information

Product

Adiponectin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Pig

Immunogen

Synthetic peptide taken within amino acid region 150-243 on pig Adiponectin protein.

Accession #

GenBank: AY589691

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.65 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q69907

Overview

Involved in brown fat cell differentiation, responses to drugs, detection of oxidative stress glucose homeostasis and fatty acid oxidation.  Invovled in regulation of DNA biosynthetic processes.

Molecular Function

Hormone activity; receptor binding

Subcellular Location

Cell periphery; collagen trimer; extracellular space; cell surface; endoplasmic reticulum; perinuclear region of cytoplasm

Expression

Secreted

Alternative Nomenclature

30 kDa adipocyte complement related protein antibody

ACDC antibody

ACRP 30 antibody

Adipocyte antibody

Adipocyte C1q and collagen domain containing protein antibody

Adipocyte complement related 30 kDa protein antibody

adipocyte-specific secretory protein antibody

Adiponectin antibody

adiponectin, C1Q and collagen domain containing antibody

AdipoQ antibody

Adipose most abundant gene transcript 1 antibody

Adipose specific collagen like factor antibody

ADIPQTL1 antibody

ADPN antibody

APM 1 antibody

C1q and collagen domain-containing protein antibody

GBP 28 antibody

Gelatin binding protein antibody

Gelatin binding protein 28 antibody

General Information

Product

N-Chimaerin Antibody

Description

Affinity Purified N-Chimaerin isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on alpha 2 Chimaerin protein.

Accession #

NCBI:  NP_001813

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P15882

Overview

GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.

Molecular Function

GTPase activation

Subcellular Location

Cytosol

Expression

In neurons in brain regions that are involved in learning and memory processes.

Structure

Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.

Alternative Nomenclature

A-chimaerin antibody

Alpha-chimerin antibody

ARHGAP2 antibody

CHN antibody

Chn1 antibody

N chimaerin antibody

NC antibody

Rho GTPase-activating protein 2 antibody

RHOGAP2 antibody

General Information

Product

Chimaerin beta 2 Antibody

Description

Affinity Purified Beta-chimaerin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-180 on beta 2-chimaerin protein.

Accession #

NCBI: NM_004067

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P52757

Overview

GTPase-activating protein for p21-rac.  May play role in progression from low-grade to high-grade tumors.

Molecular Function

Metal binding; Zinc

Subcellular Location

Membrane

Expression

Brain, pancreas, heart, placenta.  Weakly expressed in kidney and liver.

Structure

Contains 1 phorbol-ester/DAG-type zinc finger; 1 Rho-GAP domain; 1 SH2 domain.

Alternative Nomenclature

ARHGAP3 antibody

BCH antibody

CHN2 antibody

MGC138360 antibody

Rho GTPase activating protein 3 antibody

RHOGAP3 antibody

General Information

Product

CXCR4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 15-65 on CXCR4 protein.

Accession #

GenBank:  CAA12166

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P61073

Overview

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Molecular Function

Host-virus Interaction

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome

Expression

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Structure

Monomer. Can form dimers.

Alternative Nomenclature

C-X-C chemokine receptor type 4 antibody

CD184 antibody

Chemokine CXC Motif Receptor 4 antibody

CXCR4 antibody

D2S201E antibody

FB22 antibody

Fusin antibody

HM89 antibody

HSY3RR antibody

LAP 3 antibody

LCR1 antibody

LESTR antibody

Leukocyte derived seven transmembrane domain receptor antibody

Lipopolysaccharide associated protein 3 antibody

Neuropeptide Y receptor Y3 antibody

NPY3R antibody

NPYR antibody

NPYRL antibody

Probable G protein coupled receptor lcr1 homolog antibody

SDF 1 receptor antibody

Stromal cell derived factor 1 receptor antibody

WHIM antibody

General Information

Product

DOC2B Antibody

Description

Affinity Purified Double C2-like domain-containing protein beta Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic Peptide taken within amino acid region 360-412 on DOC2b gene.

Accession #

GenBank:  AAB47747.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P70610

Overview

calcium ion-dependent exocytosis of neurotransmitter;positive regulation of insulin secretion

Molecular Function

calcium-dependent phospholipid binding;transporter activity

Subcellular Location

Cell membrane, Cytoplasm, Membrane

Expression

Expressed in brain; highly enriched in neurons

Alternative Nomenclature

Double C2-like domain-containing protein beta antibody

OTTMUSP00000006522 antibody

RP23 78H4.2 antibody

General Information

Product

EHD3 Antibody

Description

Affinity Purified EH domain-containing protein 3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse Rat

Immunogen

Synthetic peptide taken within amino acid region 475-535 on human EH-domain containing protein 3.

Accession #

NCBI:  NP_055416.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NZN3

Overview

Plays a role in endocytic transport

Molecular Function

ATP binding;GTPase activity;nucleic acid binding;calcium ion binding;GTP binding

Subcellular Location

Cell membrane, Cytoplasm, Endosome, Membrane

Expression

Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.

Structure

Homooligomer, and heterooligomer with EHD1, EHD2 and EHD4

Alternative Nomenclature

EH domain containing 3 antibody

EHD2 antibody

EHD3 antibody

PAST3 antibody

General Information

Product

EHD4 Antibody

Description

Affinity Purified EH domain-containing protein 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse Rat

Immunogen

Synthetic peptide taken within amino acid region 420-450 on EH-domain containing 4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9H223

Overview

Plays a role in early endosomal transport

Molecular Function

ATP binding;GTPase activity;nucleic acid binding;calcium ion binding;GTP binding

Subcellular Location

Cell membrane, Endosome, Membrane

Expression

Highly expressed in pancreas and heart.

Structure

Homooligomer, and heterooligomer with EHD1, EHD2 and EHD3

Alternative Nomenclature

EH domain containing 4 antibody

Hepatocellular carcinoma associated protein 10/11 antibody

HCA11 antibody

HGNC:3245 antibody

Ortholog of rat pincher antibody

PAST4 antibody

General Information

Product

GCN2 Antibody

Description

Affinity Purified eIF2alpha kinase Antibody

Verified Applications

CM, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1600-1700 on human GCN2 protein.

Accession #

GenBank:  CAB58363.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9P2K8

Overview

Can phosphorylate alpha subunit of EIF2 and mediates translational control.

Molecular Function

ATP binding; Nucleotide binding

Subcellular Location

Cytosolic ribosome

Expression

Liver, brain.

Structure

Contains 2 protein kinase domains; Contains 1 RWD domain.

Alternative Nomenclature

Eif2ak4 antibody

Eukaryotic Translation Initiation Factor 2 alpha kinase 4 antibody

GCN2 antibody

GCN2 eIF2alpha kinase antibody

GCN2 like protein antibody

KIAA1338 antibody

MGCN2 antibody

General Information

Product

IL17C Antibody

Description

Affinity Purified Pan Interleukin-17 receptor C Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide corresponding to IL17RC protein common to C1, C2, C5, C8, C9, C11, C12 isoforms.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.86-0.94 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8NAC3

Molecular Function

interleukin-17 receptor activity

Subcellular Location

Cell membrane, single-pass type 1 membrane protein (Note: soluble isoforms may be produced)

Expression

Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta.

Alternative Nomenclature

CX2 antibody

Cytokine CX2 antibody

IL 17C antibody

IL 21 antibody

Interleukin-17C antibody

MGC126884 antibody

MGC138401 antibody

General Information

Product

LIMK1 Antibody

Description

Affinity Purified LIM domain kinase 1 isoform 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 550-647 on human LIM Kinase 1 protein.

Accession #

NCBI:  NP_002305.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P53667

Overview

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways.

Molecular Function

ATP binding, protein kinase activity, protein serine/threonine kinase activity, zinc ion binding, heat shock protein binding

Subcellular Location

Cytoplasm, nucleus

Expression

Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Alternative Nomenclature

LIM domain kinase 1 antibody

LIM motif-containing protein kinase antibody

LIMK antibody

LIMK-1 antibody