General Information

Product

PDE11A Antibody

Description

Affinity Purified Cyclic Nucleotide Phosphodiesterase 11A1 Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on PDE11A protein, common to all PDE11A variants.

Accession #

GenBank: CAB82573.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q9HCR9

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

Molecular Function

Hydrolase, metal-ion binding, cGMP binding

Subcellular Location

Cytoplasm

Expression

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed i

Alternative Nomenclature

5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A antibody

Cyclic nucleotide phosphodiesterase 11A1 antibody

Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A antibody

FLJ23693 antibody

MGC133355 antibody

MGC133356 antibody

PDE 11A antibody

pde11 antibody

pde11a2 antibody

Phosphodiesterase 11A antibody

PPNAD2 antibody

General Information

Product

PDE11A Antibody

Description

Affinity Purified Cyclic Nucleotide Phosphodiesterase 11A1 Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 454-468 of human PDE11A.

Accession #

GenBank: CAB82573.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q9HCR9

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

Molecular Function

Hydrolase, metal-ion binding, cGMP binding

Subcellular Location

Cytoplasm

Expression

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis.

Alternative Nomenclature

5''-cyclic-AMP and -GMP phosphodiesterase 11A 

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A 

Cyclic nucleotide phosphodiesterase 11A1 

Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A 

PDE 11A 

pde11 

pde11a2 

Phosphodiesterase 11A 

PPNAD2 

General Information

Product

Chimaerin beta 2 Antibody

Description

Affinity Purified Beta-chimaerin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-180 on beta 2-chimaerin protein.

Accession #

NCBI: NM_004067

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P52757

Overview

GTPase-activating protein for p21-rac.  May play role in progression from low-grade to high-grade tumors.

Molecular Function

Metal binding; Zinc

Subcellular Location

Membrane

Expression

Brain, pancreas, heart, placenta.  Weakly expressed in kidney and liver.

Structure

Contains 1 phorbol-ester/DAG-type zinc finger; 1 Rho-GAP domain; 1 SH2 domain.

Alternative Nomenclature

ARHGAP3 antibody

BCH antibody

CHN2 antibody

MGC138360 antibody

Rho GTPase activating protein 3 antibody

RHOGAP3 antibody

General Information

Product

Chimaerin beta 3 Antibody

Description

Affinity Purified Beta-Chimaerin isoform 3 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-100 on human beta-chimaerin isoform 3 protein.

Accession #

NCBI:  NP_001279998.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P52757

Overview

GTPase-activating protein for p21-rac.  May play role in progression from low-grade to high-grade tumors.

Molecular Function

Metal binding; Zinc

Subcellular Location

Membrane

Expression

Brain, pancreas, heart, placenta.  Weakly expressed in kidney and liver.

Structure

Contains 1 phorbol-ester/DAG-type zinc finger; 1 Rho-GAP domain; 1 SH2 domain.

Alternative Nomenclature

ARHGAP3 antibody

BCH antibody

Beta chimerin antibody

Chimaerin3 antibody

CHN3 antibody

MGC138360 antibody

Rho GTPase activating protein 3 antibody

RHOGAP3 antibody

General Information

Product

CXCR1 Antibody Affinity Purified

Description

Affinity Purified Chemokine (C-X-C motif) receptor 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Goat

Species Cross Reactivity

Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on mouse CXCR1 protein.

Accession #

NCBI:  NM_178241.4

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.50-1.2 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q810W6

Overview

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Molecular Function

Chemotaxis

Subcellular Location

Cell membrane; Multi-pass membrane protein

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

C C antibody

C C CKR 1 antibody

C-X-C chemokine receptor type 1 antibody

CCCKR1 antibody

CD 181 antibody

CD128 antibody

CKR 1 antibody

CMKAR1 antibody

CXC-R1 antibody

High affinity interleukin-8 receptor A antibody

IL 8 receptor type 1 antibody

IL 8R A antibody

General Information

Product

Estrogen Receptor alpha Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 30-80 on human ESTRA protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P03372

Overview

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Molecular Function

Activator, Receptor

Subcellular Location

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Expression

Widely expressed. Isoform 3 is not expressed in the pituitary gland

Structure

Belongs to the nuclear hormone receptor family. NR3 subfamily

Alternative Nomenclature

DKFZp686N23123 antibody

ER alpha antibody

ER antibody

Era antibody

ESR antibody

ESR1 antibody

ESRA antibody

Estradiol receptor antibody

Estrogen nuclear receptor alpha antibody

Estrogen receptor 1 antibody

Estrogen receptor antibody

ESTRR antibody

Major ORF antibody

NR3A1 antibody

Nuclear receptor subfamily 3 group A member 1 antibody

General Information

Product

Bestrophin 3 Antibody

Verified Applications

CM, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within the last 50 amino acids from the C-terminus of rat Bestrophin-3 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q6H1V1

Overview

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Molecular Function

Ion transport; Calcium, Chloride.

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Expression

Skeletal muscle and weakly in brain, spinal cord, bone marrow and retina.

Structure

Belongs to bestrophin Family

Alternative Nomenclature

BEST 3 antibody

Bestrophin3 antibody

MGC13168 antibody

MGC40411 antibody

Vitelliform macular dystrophy 2-like protein 3 antibody

VMD2L3 antibody

General Information

Product

Bestrophin 4 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 400-500 on Bestrophin 4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8NFU0

Overview

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Molecular Function

Chloride Channel

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta.

Structure

Belongs to bestrophin Family

Alternative Nomenclature

BEST 4 antibody

MGC126872 antibody

Vitelliform macular dystrophy 2 like 2 antibody

VMD2-like gene 2 antibody

VMD2L2 antibody

General Information

Product

BMP1 Antibody

Description

Affinity Purified Bone morphogenetic protein 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human BMP1 protein.

Accession #

NCBI:  NP_001190

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.56 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500

Protein

Uniprot #

P13497

Overview

Cleaves the C-terminal propeptides of procollagen I, II and II. Induces bone and cartilage formation.

Molecular Function

Chondrogenesis; Differentiation; Osteogenesis; Calcium, Zinc, Metal binding

Subcellular Location

trans-Golgie network; secreted; ECM

Expression

Ubiquitous

Structure

Belongs to peptidase M12A family. Contains 5 CUB domains and 2 EGF-like domains.

Alternative Nomenclature

Mammalian tolloid protein antibody

mTld antibody

OI13 antibody

PCOLC antibody

PCP2 antibody

Procollagen C endopeptidase antibody

TLD antibody

Tolloid, Drosophila, homolog of antibody

General Information

Product

CXCR5 Antibody Affinity Purified

Description

Affinity Purified Chemokine (C-X-C motif) receptor 5 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 320-370 on human Chemokine (C-X-C motif) receptor 5 protein.

Accession #

Gen Bank: AAI10353.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.50-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q2YD84

Overview

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Molecular Function

B-cell activation.

Subcellular Location

Integral component of plasma membrane; External side of plasma membrane

Expression

Expression in mature B-cells and Burkitt lymphoma cells

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

BLR 1 antibody

Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) antibody

C X C chemokine receptor type 5 antibody

CD 185 antibody

Chemokine receptor 5 antibody

CXC chemokine receptor type 5 antibody

CXCR-5 antibody

MDR 15 antibody

MGC117347 antibody

Monocyte-derived receptor 15 antibody