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PDE5A Antibody

Product no.: PD5A-101AP

$320.00

General Information
Product	PDE5A Antibody
Description	Affinity Purified cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1 Antibody
Verified Applications	CM, ELISA, ICC/IF, IHC-P, IHC-Fr, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Pig, Rat
Immunogen	Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein.
Specificity	This antibody detects 99 and 89 kDa PDE5A proteins in various tissues. This antibody does not cross-react with other PDE family members.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.55-0.60 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:250
Western Blot	1:500-1:1,000
Protein
Uniprot #	O76074
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Molecular Function	Hydrolase, 3',5'-cyclic-GMP phosphodiesterase activity, cGMP binding
Subcellular Location	cytosol
Expression	Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Alternative Nomenclature	5''-cyclic phosphodiesterase antibody CGB PDE antibody cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase antibody cGMP binding/cGMP specific phosphodiesterase antibody cGMP specific 3'5' cyclic phosphodiesterase antibody cGMP specific phosphodiesterase PDE5A2 antibody cGMP specific phosphodiesterase type 5A antibody cGMP-specific 3'' antibody CN5A antibody CN5N antibody PDE 5 antibody PDE 5A antibody PDE5A1 antibody Phosphodiesterase 5A antibody Phosphodiesterase 5A cGMP specific antibody Phosphodiesterase isozyme 5 antibody

Protein information supplied by UniProt

Fabgennix PDE5A Antibody has been used in 22 Publications
Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518. PMID25704994	Immunofluorescence, Western Blot; Human
Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994	Immunohistochemistry, Western Blot; Human
Nordgaard, Julie Carøe, et al. "Role of Ser102 and Ser104 as Regulators of cGMP Hydrolysis by PDE5A." PloS one 9.9 (2014): e107627. PMID25247292	Immunofluorescence, Western Blot; Human
Akkerman, Sven et al. “PDE5 Inhibition Improves Object Memory in Standard Housed Rats but Not in Rats Housed in an Enriched Environment: Implications for Memory Models?” Ed. Patrizia Campolongo. PLoS ONE 9.11 (2014): e111692. PMC4221101	Western Blot; Rat
Witting, Nanna, et al. "Effect of sildenafil on skeletal and cardiac muscle in Becker muscular dystrophy." Annals of neurology 76.4 (2014): 550-557. PMID25042931	Western Blot; Mouse
Carøe Nordgaard, Julie et al. “Role of Ser102 and Ser104 as Regulators of cGMP Hydrolysis by PDE5A.” Ed. David D. Roberts. PLoS ONE 9.9 (2014): e107627. PMC4172485	Western Blot; Human
Mietens, Andrea, et al. "Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not." Molecular and cellular endocrinology 349.2 (2012): 145-153. PMID21996373	Immunohistochemistry, Western Blot; Huma, Rat
Shukla, Praveen, Chengwen Sun, and Stephen T. O’Rourke. “Melatonin Inhibits Nitric Oxide Signaling by Increasing PDE5 Phosphorylation in Coronary Arteries.” American Journal of Physiology - Heart and Circulatory Physiology 303.12 (2012): H1418–H1425. PMC3532536	Western Blot; Pig
Ückert, Stefan, et al. "Expression and distribution of phosphodiesterase isoenzymes in the Human seminal vesicles." The journal of sexual medicine 8.11 (2011): 3058-3065. PMID21810184	Immunohistochemistry, Western Blot; Human
Luong, Christina, et al. "Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia." Circulation 123.19 (2011): 2120-2131. PMID21537000	Western Blot; Rat
Adderley, Shaquria P. et al. “Identification of Cytosolic Phosphodiesterases in the Erythrocyte: A Possible Role for PDE5.” Medical Science Monitor : International Medical Journal of Experimental and Clinical Research 17.5 (2011): CR241–CR247. PMC3366467	Western Blot; Human, Rabbit
Ückert, S, et al. "Expression And Distribution Of Key Enzymes Of The Cyclic GMP Signaling In The Human Clitoris: Relation To Phosphodiesterase Type 5 (PDE5)." International Journal Of Impotence Research 23.5 (2011): 206-212. PMID21697861	Immunohistochemistry; Human
Mokni, Walid et al. “Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II.” Ed. Karl-Wilhelm Koch. PLoS ONE 5.12 (2010): e14227. PMC2997062	Immunohistochemistry, Western Blot; Rat
Murthy, K S. “Contractile Agonists Attenuate cGMP Levels by Stimulating Phosphorylation of cGMP-Specific PDE5; an Effect Mediated by RhoA/PKC-Dependent Inhibition of Protein Phosphatase 1.” British Journal of Pharmacology 153.6 (2008): 1214–1224. PMC2275441	Immunoprecipitation, Western Blot; Rabbit
Sasseville, Maxime, et al. "Partie 5 3’5’-cyclic guanosine monophosphate-specific phosphodiesterases in the porcine cumulus-oocyte complex." Endocrinology. 2008 Nov;149(11):5568-76. doi: 10.1210/en.2008-0547. Epub 2008 Jul 31 PMID18669600	Immunodepletion, Western Blot; Pig
Albrecht, Knut, et al. "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the Human vagina: A potential forensic value?." Journal of forensic and legal medicine 14.5 (2007): 270-274. PMID17113813	Immunohistochemistry; Human
Ückert, Stefan, et al. "Immunohistochemical Description of Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Labia Minora." The Journal of Sexual Medicine 4.3 (2007): 602-608. PMID17498099	Immunofluorescence; Human
Werkström, Viktoria, et al. "Phosphodiesterase 5 In The Female Pig And Human Urethra: Morphological And Functional Aspects."BJU International 98.2 (2006): 414-423. PMID16626307	Immunohistochemistry; Human, Pig
Liu, Wu-Jiang, et al. "Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats." Asian journal of andrology 7.4 (2005): 381. PMID16281085	Western Blot; Rat
Wang, Lei, et al. "Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone." Journal of Cerebral Blood Flow & Metabolism 25.9 (2005): 1150-1158. PMID15815584	Immunohistochemistry, Western Blot; Rat
Ückert, Stefan, et al. "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in Human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." Urology 65.3 (2005): 604-610. PMID15780401	Immunohistochemistry; Human
Monfort, Pilar, María‐Dolores Muñoz, and Vicente Felipo. "Chronic hyperammonemia in vivo impairs long‐term potentiation in hippocampus by altering activation of cyclic GMP‐dependent‐protein kinase and of phosphodiesterase 5." Journal of neurochemistry 94.4 (2005): 934-942. PMID16092938	Western Blot; Rat

Publishing research using PD5A-101AP? Please let us know, we can cite the reference in this datasheet.

To view the Specification Sheet for PDE5A Antibody, please click the link below:

PDE5A Antibody | FabGennix

I am looking for an antibody for PDE5. I would like to use this antibody on rat lung tissue for immunohistochemistry staining, immunofluorescence staining and western blot. On the internet I can find some antibodies, but I’m not sure if they will work well enough on rat. Do you have an antibody which you can recommend for this?
1. Our PDE5A antibody (PD5A-101AP) will work in immunohistochemistry staining, immunofluorescence staining and western blot with rat tissues. If you visit the publications tab under the PD5A-101AP product page you can see a summary of several publications that used this antibody. PMID21996373, PMC2997062 and PMID15815584 are some papers that utilize both immunohistochemistry and Western Blot in rat samples. We also have a phospho specific PDE5A antibody (PPD5A-140AP) that has been validated in the same applications and tissues.

Customer ratings for PDE5A Antibody

Number of ratings: 2
Average rating: 3.5

IHC with paraffin-embedded sections on human tissue. 1:10 primary antibody dilution overnight.
from Joseph Alzar on 03/22/2024

Good
from Anonymous on 05/28/2016

IHC with paraffin-embedded sections on human tissue. 1:10 primary antibody dilution overnight.

All incoming ratings are posted by actual shop visitors / webshop customers and their content is checked by the operator by means of a visual inspection.

Accessories

Product

Note

Status

Price

PDE5A Antibody FITC

PD5A-FITC

$375.00 *

PDE5A Antibody BIOTIN

PD5A-BIOTIN

$375.00 *

PDE5A Blocking Peptide

P-PD5A

$155.00 *

HRP-Conjugated PDE5A Antibody

PD5A-HRP

$375.00 *

PDE5A Positive Control

PC-PD5A

$220.00 *

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PPD5A-140AP

Phospho-PDE5A Antibody

$375.00 *

Antibody against recombinant PDE5A

PDE5A Antibody

$285.00 *

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Browse these categories as well: cGMP, Oxidative Stress, Atherosclerosis, Hypoxia, Metabolism, Phosphodiesterases, Primaries

Phospho-PDE5A Antibody

Product no.: PPD5A-140AP

$375.00

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General Information
Product	Phospho-PDE5A Antibody
Description	Affinity Purified Phosphorylated Phosphodiesterase 5A Antibody
Verified Applications	ELISA, ICC, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Bovine, Human, Mouse, Pig, Rat, Sheep
Immunogen	Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein. Phosphoryalted
Specificity	This antibody will detect only PDE5A protein that has been phosphorylated at the PKG site. Will not detect unphosphorylated PDE5A, or other PDE family members.
Accession #	GenBank: EAX05277.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	1.0-1.25 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:100
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:100
Immunofluorescence	1:100
Immunohistochemistry	1:100
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	UPI0000EE2B22
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Molecular Function	Hydrolase, 3',5'-cyclic-GMP phosphodiesterase activity, cGMP binding
Subcellular Location	cytosol
Expression	Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Alternative Nomenclature	5''-cyclic phosphodiesterase antibody CGB PDE antibody cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase antibody cGMP binding/cGMP specific phosphodiesterase antibody cGMP specific phosphodiesterase type 5A antibody CN5A antibody CN5N antibody PDE 5 antibody PDE 5A antibody PDE5A1 antibody Phosphodiesterase 5A antibody Phosphodiesterase 5A cGMP specific antibody Phosphodiesterase isozyme 5 antibody

Protein information supplied by UniProt

Fabgennix Phospho-PDE5A Antibody has been used in 14 Publications
MHerrera, Emilio A., et al. "The role of nitric oxide signaling in pulmonary circulation of highand low-altitude newborn sheep under basal and acute hypoxic conditions." Nitric Oxide, 89, 71-80. PMID: 31063821	Western Blot; *Sheep*
Musicki, Biljana, et al. "Testosterone replacement in transgenic sickle cell mice controls priapic activity and upregulates PDE5 expression and eNOS activity in the penis." Andrology 6.1 (2018): 184-191. PMID29145710	Western Blot; *Mouse*
Nino, Paula Katherina Bautista, et al. "Phosphodiesterase 1 regulation is a key mechanism in vascular aging." Clinical Science (2015): CS20140753. PMID26464516	Western Blot; *Mouse*
Nino, Paula Katherina Bautista, et al. "Phosphodiesterase 1 regulation is a key mechanism in vascular aging." Clinical Science (2015): CS20140753. PMID26464516	Western Blot; *Mouse*
Nino, Paula Katherina Bautista, et al. "Phosphodiesterase 1 regulation is a key mechanism in vascular aging." Clinical Science (2015): CS20140753. PMID26464516	Western Blot; *Mouse*
Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518.PMID25550199	Western Blot; *Mouse*

Click Here for the complete list of all FabGennix Phospho-PDE5A Antibody publications

Publishing research using PPD5A-140AP? Please let us know, we can cite the reference in this datasheet.

To view the Specification Sheet for Phospho-PDE5A Antibody, please click the link below:

Phospho-PDE5A Antibody | FabGennix

Which phosphorylation site of PDE5A does this Phospho-PDE5A Antibody (PPD5A-140AP) recognize?
1. This antibody detects only PDE5A protein phosphorylated at Serine 148. This Antibody will detect phosphorylation at the PKG site.

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Phospho-PDE5A Antibody FITC

PPD5A-FITC

$425.00 *

Phospho-PDE5A Antibody BIOTIN

PPD5A-BIOTIN

$425.00 *

Phospho-PDE5A Blocking Peptide

P-PPD5A

$195.00 *

Phospho-PDE5A Positive Control

PC-PPD5A

$220.00 *

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PD5A-101AP

PDE5A Antibody

$320.00 *

PD5A-112AP

PDE5A Antibody

$285.00 *

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PDE5A Antibody

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SESN3 Antibody

Product no.: SESN-301AP

$285.00

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Description

General Information
Product	SESN3 Antibody Affinity Purified
Description	Affinity Purified SESN3 protein Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 1-50 on SESN3 protein.
Accession #	GenBank: AAH17296.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68-0.80 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	P58005
Subcellular Location	Nucleus
Expression	Widely expressed.
Alternative Nomenclature	SEST3 antibody Sestrin 3 antibody

Protein information supplied by UniProt

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SESN3 Antibody FITC

SESN3-FITC

$375.00 *

SESN3 Antibody BIOTIN

SESN3-BIOTIN

$375.00 *

SESN3 Blocking Peptide

P-SESN3

$155.00 *

SESN3 Positive Control

PC-SESN3

$200.00 *

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SESN2 Antibody

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SESN1 Antibody

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SIRT7 Antibody

Product no.: SIRT7-701AP

$285.00

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Description

General Information
Product	SIRT7 Antibody
Description	Affinity Purified Sirtuin (silent mating type information regulation 2 homolog) 7 Antibody C-epitope
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 340-390 on human SIRT7 protein.
Accession #	GenBank: AAH17305.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	C-epitope
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q9NRC8
Overview	NAD-dependent protein deacetylase that specifially mediates deacetylation of histone H3 at 'Lys-18'. Displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression.
Molecular Function	Chromatin binding, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), metal ion binding
Subcellular Location	Cytoplasm, nucleus, nucleolus. (Note: Located close to the nuclear membrane when in cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
Expression	Detected in liver, spleen and testis. Detected in embryos.
Structure	Belongs to the Sirtuin Family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain.
Alternative Nomenclature	NAD dependent deacetylase sirtuin 7 antibody Regulatory protein SIR2 homolog 7 antibody Silent mating type information regulation 2 homolog antibody SIR2 L7 antibody SIR2 like protein 7 antibody Sir2 related protein type 7 antibody SIRT7 antibody Sirtuin 7 antibody Sirtuin type 7 antibody

Protein information supplied by UniProt

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Price

SIRT7 Antibody FITC

SIRT7-FITC

$375.00 *

SIRT7 Antibody BIOTIN

SIRT7-BIOTIN

$375.00 *

SIRT7 Blocking Peptide

P-SIRT7

$155.00 *

SIRT7 Antibody Positve Control

PC-SIRT7

$200.00 *

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SIR1-101AP SIRT1 Antibody $285.00 *	SIR2-201AP SIRT2 Antibody $285.00 *	SIR3-301AP SIRT3 Antibody $285.00 *
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Browse these categories as well: Transcription Factors, Transcription, DNA / RNA, Chromatin Modifying Enzymes, Acetylation, Apoptosis, Apoptosis, Atherosclerosis, Energy Metabolism, Metabolism & Homeostasis, Metabolism, Second Messengers, Primaries

SUR1 Antibody

Product no.: SUR1-101AP

$285.00

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Description

General Information
Product	SUR1 Antibody
Description	Affinity Purified ATP-binding cassette sub-family C member 8 Antibody
Verified Applications	ELISA, IHC-Fr, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to positions 1560-1582.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.6 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000-1:100,000
ELISA	1:10,000-1:100,000
Immunohistochemistry	1:200
Western Blot	1:500
Protein
Uniprot #	Q09429
Overview	Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.
Molecular Function	Receptor, ATPase activity, coupled to transmembrane movement of substances, ATP binding
Subcellular Location	Membrane; Multi-pass membrane protein
Structure	Interacts with KCNJ11.
Alternative Nomenclature	ABC36 antibody Abcc8 antibody ATP binding cassette sub family C (CFTR/MRP) member 8 antibody HHF1 antibody HI antibody HRINS antibody MRP8 antibody PHHI antibody Sulfonylurea receptor (hyperinsulinemia) antibody SUR antibody SUR1 antibody SUR1delta2 antibody TNDM2 antibody

Protein information supplied by UniProt

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Price

SUR1 Antibody FITC

SUR1-FITC

$375.00 *

SUR1 Antibody BIOTIN

SUR1-BIOTIN

$375.00 *

SUR1 Blocking Peptide

P-SUR1

$155.00 *

SUR1 Positive Control

PC-SUR1

$200.00 *

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TLR4 Antibody

Product no.: TLR-401AP

$285.00

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Description

General Information
Product	TLR4 Antibody Affinity Purified
Description	Affinity Purified Toll-like receptor 4 Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Human
Immunogen	Synthetic peptide taken within amino acid region 970-1000 on human TLR4 protein.
Accession #	GenBank: AAF05316.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.66-0.8 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:20,000
ELISA	1:20,000
Western Blot	1:500
Protein
Uniprot #	O00206
Overview	Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+.
Molecular Function	Receptor, lipopolysaccharide binding, transmembrane signaling receptor activity
Subcellular Location	Cell membrane; Single-pass type I membrane protein
Expression	Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
Structure	Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via the
Alternative Nomenclature	ARMD10 antibody CD284 antibody Homolog of Drosophila toll antibody hToll antibody TLR 4 antibody Toll (Drosophila) homolog antibody TOLL antibody Toll Endotoxin Hyporesponsiveness antibody Toll like receptor 4 antibody

Protein information supplied by UniProt

Accessories

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Price

TLR4 Antibody FITC

TLR4-FITC

$375.00 *

TLR4 Antibody BIOTIN

TLR4-BIOTIN

$375.00 *

TLR4 Blocking Peptide

P-TLR4

$155.00 *

TLR4 Positive Control

PC-TLR4

$200.00 *

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Browse these categories as well: Macrophage / Inflammation, Diagnostic Markers, Immunology, Host Virus Interaction, Atherosclerosis, T Cells, TLR Signaling, Primaries, Sting Pathway

TLR6 Antibody

Product no.: TLR-601AP

$285.00

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Description

General Information
Product	TLR6 Antibody
Description	Affinity Purified Toll-like receptor 6 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Cat, Human, Mouse, Rat, Pig
Immunogen	Synthetic peptide taken within amino acid region 195-225 on human TLR6 protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.78-0.80 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:20,000
ELISA	1:20,000
Immunohistochemistry	1:100
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q9Y2C9
Overview	Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.
Molecular Function	Receptor, diacyl lipopeptide binding, transmembrane signaling receptor activity
Subcellular Location	Cell membrane; Single-pass type I membrane protein, Cytoplasmic vesicle > phagosome membrane; Single-pass type I membrane protein
Expression	Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Structure	Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains (By similarity). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initation.
Alternative Nomenclature	CD286 antibody TLR 6 antibody Toll like receptor 6 precursor antibody

Protein information supplied by UniProt

Accessories

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Status

Price

TLR6 Antibody FITC

TLR6-FITC

$375.00 *

TLR6 Antibody BIOTIN

TLR6-BIOTIN

$375.00 *

TLR6 Blocking Peptide

P-TLR6

$155.00 *

TLR6 Positive Control

PC-TLR6

$200.00 *

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Browse these categories as well: Macrophage / Inflammation, Diagnostic Markers, Immunology, Defensin, Transmembrane, Nuclear Signaling Pathways, Atherosclerosis, TLR Signaling, Primaries, Sting Pathway

Glucose Transporter GLUT1 Antibody

Product no.: GLUT1-112AP

$285.00

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Description

General Information
Product	Glucose Transporter GLUT1 Antibody
Description	Glucose transporter glycoprotein GLUT1 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Sheep
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequences on GLUT1 protein.
Accession #	GenBank: AAC28635.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:12,000
ELISA	1:12,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:5,000
Protein
Uniprot #	P11166
Overview	Facilitative glucose transporter. May be responsible for constitutive or basal glucose uptake.
Molecular Function	Sugar Transport
Subcellular Location	Cell membrane; Multi-pass membrane protein; melanosome
Expression	Detected in erythrocytes. Variable expression in many human tissues.
Structure	Transmembrane helix
Alternative Nomenclature	DYT17 antibody DYT18 antibody erythrocyte/brain antibody Erythrocyte/hepatoma glucose transporter antibody facilitated glucose transporter member 1 antibody Glucose transporter type 1 erythrocyte/brain antibody GLUT1DS antibody GLUTB antibody GT1 antibody GTG1 antibody Gtg3 antibody HepG2 glucose transporter antibody MGC141895 antibody MGC141896 antibody PED antibody RATGTG1 antibody SLC2A1 antibody Solute carrier family 2, facilitated glucose transporter member 1 antibody

Protein information supplied by UniProt

Accessories

Product

Note

Status

Price

Glucose Transporter GLUT1 Antibody FITC

GLUT1.2-FITC

$375.00 *

Glucose Transporter GLUT1 Antibody BIOTIN

GLUT1.2-BIOTIN

$375.00 *

Glucose Transporter GLUT1 Blocking Peptide

P-GLUT1.2

$155.00 *

Glucose Transporter GLUT1 Positive Control

PC-GLUT1

$200.00 *

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GLUT1-101AP

Glucose Transporter GLUT1 Antibody

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CXCR3 Antibody

Product no.: CXCR3-312AP

$285.00

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Description

General Information
Product	CXCR3 Antibody
Description	Affinity Purified IP10 Receptor Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human
Immunogen	Synthetic peptide taken within amino acid region 1-50 on human CXCR3 protein
Accession #	NCBI: NP_001495
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50-0.60 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	P49682
Molecular Function	G-protein coupled receptor, Transducer, chemokine binding
Subcellular Location	Cell membrane; Multipass membrane protein
Expression	Isoforms 1 and 2 are expressed mainly in the heart, kidney, liver and skeletal muscle. Isoform 1 is additionally found in placenta, and Isoform 2 is also expressed in endothelial cells. At protein level, expression is present in T-cells.
Structure	Homomer, forms heteromers with ACKR4
Alternative Nomenclature	C-X-C chemokine receptor type 3 antibody CD 183 antibody CD182 antibody Chemokine CXC Motif Receptor 3 antibody CKR L2 antibody CKR-L2 antibody CMKAR3 antibody CXC-R3 antibody G protein-coupled receptor 9 antibody GPR9 antibody Interferon-inducible protein 10 receptor antibody IP-10 receptor antibody Mig R antibody Mig receptor antibody

Protein information supplied by UniProt

Accessories

Product

Note

Status

Price

CXCR3 Antibody FITC

CXCR3h-FITC

$375.00 *

CXCR3 Antibody BIOTIN

CXCR3h-BIOTIN

$375.00 *

CXCR3 Blocking Peptide

P-CXCR3h

$155.00 *

CXCR3 Positive Control

PC-CXCR3

$200.00 *

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CXCR6 Antibody

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CXCR3 Antibody

Product no.: CXCR3-301AP

$285.00

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Description

General Information
Product	CXCR3 Antibody Affinity Purified
Description	Affinity Purified IP10 Receptor Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IMM, WB
Host	Rabbit
Species Cross Reactivity	Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 20-70 on rat CXCR3 protein
Accession #	NCBI: NP_445867.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50-0.60 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	QJII9
Overview	Receptor for C-X-C chemokines: CXCL9, CXCCl10 and CXCL11, mediates the proliferation, survival and angiogenic activity of mesangial cells via a heterotrimeric G-protein signalling pathway
Molecular Function	G-Protein coupled receptor, Transducer, chemokine receptor activity
Subcellular Location	Cell membrane; Multipass membrane protein
Structure	Homomer, forms heteromers with ACKR4 by similarity
Alternative Nomenclature	C-X-C chemokine receptor type 3 antibody CD 183 antibody CD182 antibody Chemokine CXC Motif Receptor 3 antibody CKR L2 antibody CKR-L2 antibody CMKAR3 antibody CXC-R3 antibody G protein-coupled receptor 9 antibody GPR9 antibody Interferon-inducible protein 10 receptor antibody IP-10 receptor antibody Mig R antibody Mig receptor antibody

Protein information supplied by UniProt